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C5ar2 Gene Detail
Summary
  • Symbol
    C5ar2
  • Name
    complement component 5a receptor 2
  • Synonyms
    C5L2, E030029A11Rik, Gpr77
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442013
    NCBI Gene: 319430
  • Gene Overview
    MyGene.info: C5AR2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:16234585-16244154 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 8.77 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    128 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442013
protein coding gene Chr7:16234585-16244154 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031703
protein coding gene Chr7:13899442-13913661 (-)
A/J MGP_AJ_G0031675
protein coding gene Chr7:13697886-13709861 (-)
AKR/J MGP_AKRJ_G0031600
protein coding gene Chr7:13998875-14013595 (-)
BALB/cJ MGP_BALBcJ_G0031682
protein coding gene Chr7:13794410-13805639 (-)
C3H/HeJ MGP_C3HHeJ_G0031404
protein coding gene Chr7:14175468-14190238 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032148
protein coding gene Chr7:14654630-14665348 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029227
protein coding gene Chr7:15256307-15266697 (-)
CAST/EiJ MGP_CASTEiJ_G0030755
protein coding gene Chr7:10947698-10959911 (-)
CBA/J MGP_CBAJ_G0031363
protein coding gene Chr7:15114153-15134332 (-)
DBA/2J MGP_DBA2J_G0031519
protein coding gene Chr7:13580655-13593302 (-)
FVB/NJ MGP_FVBNJ_G0031475
protein coding gene Chr7:13475334-13485086 (-)
LP/J MGP_LPJ_G0031604
protein coding gene Chr7:14168727-14180856 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031510
protein coding gene Chr7:15078718-15088684 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032177
protein coding gene Chr7:13778481-13792941 (-)
PWK/PhJ MGP_PWKPhJ_G0030479
protein coding gene Chr7:11091922-11101760 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030306
protein coding gene Chr7:8712232-8723753 (-)
WSB/EiJ MGP_WSBEiJ_G0030852
protein coding gene Chr7:13820143-13847278 (-)



Homology
more
  • Human Ortholog
    C5AR2, complement component 5a receptor 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    C5AR2, complement component 5a receptor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C5L2, GPF77, GPR77
  • Links
    NCBI Gene ID: 27202
    neXtProt AC: NX_Q9P296
    UniProt: Q9P296

  • Chr Location
    19q13.32; chr19:47331614-47342080 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display increased inflammatory response and chemotaxis after exposure to anaphylatoxins.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 319430 NCBI Gene Model | MGI Sequence Detail 9570 C57BL/6J ±  kb
transcript NM_176912 RefSeq | MGI Sequence Detail 3522 C57BL/6  
polypeptide Q8BW93 UniProt | EBI | MGI Sequence Detail 344 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR001274 C5a1/C5a2 anaphylatoxin chemotactic receptor
    IPR027809 C5a anaphylatoxin chemotactic receptor 2
    IPR000826 Formyl peptide receptor-related
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 6
    cDNA 6

    Microarray probesets 1
References
more
  • Summaries
    All 50
    Gene Ontology 5
    Phenotypes 22
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:256336 Kovtun A, et al., Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair. Sci Rep. 2017 Oct 25;7(1):14061

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory