Hs3st5 MGI Mouse Gene Detail - MGI:2441996 - heparan sulfate (glucosamine) 3-O-sulfotransferase 5

Symbol

Hs3st5
Name

heparan sulfate (glucosamine) 3-O-sulfotransferase 5
Synonyms

D930005L05Rik, LOC382362

Feature Type

protein coding gene
IDs

MGI:2441996
NCBI Gene: 319415
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr10:36382810-36710393 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 19.31 cM
Mapping Data

2 experiments

SNPs within 2kb

8543 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441996	protein coding gene	Chr10:36382794-36710393 (+)
129S1/SvImJ	ENSMUSG00200007664	protein coding gene	Chr10:33229310-33556895 (+)
A/J	ENSMUSG00195016938	protein coding gene	Chr10:33537082-33864697 (+)
AKR/J	ENSMUSG00220027402	protein coding gene	Chr10:33215920-33543539 (+)
BALB/cJ	ENSMUSG00180015319	protein coding gene	Chr10:33625565-33953192 (+)
C3H/HeJ	ENSMUSG00175011000	protein coding gene	Chr10:33413278-33740892 (+)
C57BL/6NJ	ENSMUSG00215007293	protein coding gene	Chr10:33174096-33501731 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015238	protein coding gene	Chr10:32156242-32448075 (+)
CAST/EiJ	ENSTCUG00005027936	protein coding gene	Chr10:33656047-33973000 (+)
CBA/J	ENSMUSG00210025389	protein coding gene	Chr10:33313794-33641391 (+)
DBA/2J	ENSMUSG00185007109	protein coding gene	Chr10:33466147-33793739 (+)
FVB/NJ	ENSMUSG00205012103	protein coding gene	Chr10:33405219-33732847 (+)
JF1/MsJ	ENSUMUG00000019305	protein coding gene	Chr10:33243473-33559125 (+)
LP/J	ENSMUSG00230014909	protein coding gene	Chr10:35226923-35554492 (+)
NOD/ShiLtJ	ENSMUSG00190030368	protein coding gene	Chr10:33591343-33918960 (+)
NZO/HlLtJ	ENSMUSG00225033285	protein coding gene	Chr10:39484885-39812463 (+)
PWK/PhJ	ENSLUMG00010007456	protein coding gene	Chr10:33323484-33645495 (+)
SPRET/EiJ	ENSMSPG00010019220	protein coding gene	Chr10:34449443-34637458 (+)
WSB/EiJ	ENSIUOG00005014680	protein coding gene	Chr10:33072129-33394954 (+)

Human Ortholog

HS3ST5, heparan sulfate-glucosamine 3-sulfotransferase 5

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HS3ST5, heparan sulfate-glucosamine 3-sulfotransferase 5
Synonyms

3-OST-5, 3OST5, HS3OST5, NBLA04021
Links

HGNC:19419

NCBI Gene ID: 222537

UniProt: Q8IZT8
Chr Location

6q21-q22.1; chr6:114055093-114343209 (-) GRCh38

MGI Vertebrate Homology

Hs3st5 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: HS3ST5
Gene Tree

Hs3st5

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Hs3st5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

17
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

603
Tissues

4
cDNA Data

8
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HS3ST5

Xenbase hs3st5

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All Sequences

52
RefSeq

12
UniProt

2
CCDS

CCDS35881.1

Ensembl

ENSMUSG00000044499 (Evidence)
NCBI Gene

319415

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044499	Ensembl Gene Model \| MGI Sequence Detail	327584	C57BL/6J	± kb
transcript	ENSMUST00000167191	Ensembl \| MGI Sequence Detail	2408	Not Applicable
polypeptide	ENSMUSP00000130778	Ensembl \| MGI Sequence Detail	346	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008763 heparan sulfate glucosamine 3-O-sulfotransferase 5

(term hierarchy)
EC

2.8.2.-, 2.8.2.23
InterPro Domains

IPR037359 Heparan sulfate sulfotransferase

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR000863 Sulfotransferase domain
GlyGen

Q8BSL4 4 sites

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All nucleic 10

cDNA 8

Primer pair 2

Microarray probesets 2

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MGI:2685997

Summaries

All 45

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 15
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584

TSS for Hs3st5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92947	Chr10:36382830-36382842 (+)	26 bp
Tssr92948	Chr10:36382903-36382917 (+)	100 bp
Tssr92949	Chr10:36382946-36382993 (+)	160 bp
Tssr92950	Chr10:36383009-36383020 (+)	205 bp
Tssr92951	Chr10:36401383-36401388 (+)	18,576 bp
Tssr92952	Chr10:36504231-36504244 (+)	121,428 bp
Tssr92953	Chr10:36504259-36504276 (+)	121,458 bp
Tssr92954	Chr10:36517079-36517083 (+)	134,271 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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