Gpr4 MGI Mouse Gene Detail - MGI:2441992 - G protein-coupled receptor 4

Symbol

Gpr4
Name

G protein-coupled receptor 4

Feature Type

protein coding gene
IDs

MGI:2441992
NCBI Gene: 319197
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr7:18946463-18958099 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 9.46 cM
Mapping Data

1 experiment

SNPs within 2kb

330 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441992	protein coding gene	Chr7:18946463-18958101 (+)
129S1/SvImJ	ENSMUSG00200039225	protein coding gene	Chr7:12138478-12150554 (+)
A/J	ENSMUSG00195050968	protein coding gene	Chr7:12582613-12594248 (+)
AKR/J	ENSMUSG00220024377	protein coding gene	Chr7:10915417-10927044 (+)
BALB/cJ	ENSMUSG00180046955	protein coding gene	Chr7:12438965-12450589 (+)
C3H/HeJ	ENSMUSG00175047985	protein coding gene	Chr7:13021053-13033143 (+)
C57BL/6NJ	ENSMUSG00215053084	protein coding gene	Chr7:11252826-11264460 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029278	protein coding gene	Chr7:18501110-18513011 (+)
CAST/EiJ	ENSTCUG00005048966	protein coding gene	Chr7:13047174-13058896 (+)
CBA/J	ENSMUSG00210051437	protein coding gene	Chr7:12247753-12259831 (+)
DBA/2J	ENSMUSG00185052638	protein coding gene	Chr7:15691728-15703360 (+)
FVB/NJ	ENSMUSG00205049602	protein coding gene	Chr7:12634763-12646392 (+)
JF1/MsJ	ENSUMUG00000020208	protein coding gene	Chr7:19006110-19018374 (+)
LP/J	ENSMUSG00230045163	protein coding gene	Chr7:19980225-19992278 (+)
NOD/ShiLtJ	ENSMUSG00190049346	protein coding gene	Chr7:8903961-8916041 (+)
NZO/HlLtJ	ENSMUSG00225053029	protein coding gene	Chr7:17278348-17290031 (+)
PWK/PhJ	ENSLUMG00010041432	protein coding gene	Chr7:1852995-1865004 (+)
SPRET/EiJ	ENSMSPG00010051091	protein coding gene	Chr7:11989521-11992324 (+)
WSB/EiJ	ENSIUOG00005050962	protein coding gene	Chr7:19617064-19628709 (-)

Human Ortholog

GPR4, G protein-coupled receptor 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR4, G protein-coupled receptor 4
Synonyms

GPR6C.l, hGPR4
Links

HGNC:4497

NCBI Gene ID: 2828

UniProt: P46093
Chr Location

19q13.32; chr19:45589764-45602556 (-) GRCh38

MGI Vertebrate Homology

Gpr4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPR4
Gene Tree

Gpr4

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Phenotype Summary

33 phenotypes from 2 alleles in 4 genetic backgrounds
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Endonuclease-mediated

9
Gene trapped

9
Targeted

6
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a null allele display partial neonatal and postnatal lethality, hemorrhages, impaired association of vascular smooth muscle cells with capillaries and small arteries and veins, and impaired contact between mesangial cells and renal glomerular capillaries.

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All GO Annotations

45
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

601
Tissues

3
cDNA Data

11
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpr4

ZFIN gpr4

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All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS20893.1

Ensembl

ENSMUSG00000044317 (Evidence)
NCBI Gene

319197

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044317	Ensembl Gene Model \| MGI Sequence Detail	11637	C57BL/6J	± kb
transcript	ENSMUST00000060225	Ensembl \| MGI Sequence Detail	2882	Not Applicable
polypeptide	ENSMUSP00000061243	Ensembl \| MGI Sequence Detail	365	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001644 G-protein coupled receptor 4

(term hierarchy)
PDB

8ZF9, 8ZFC, 8ZFD, 8ZFE, 9JVG, 9JVH
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR002276 G protein-coupled receptor 4 orphan

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

Q8BUD0 2 sites

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All nucleic 13

cDNA 11

Primer pair 2

Microarray probesets 3

Summaries

All 56

Developmental Gene Expression 1

Gene Ontology 12

Phenotypes 25
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:380480 Li R, et al., GPRASP1 loss-of-function links to arteriovenous malformations by endothelial activating GPR4 signals. Brain. 2024 Apr 4;147(4):1571-1586

TSS for Gpr4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr64802	Chr7:18946446-18946471 (+)	-4 bp
Tssr64803	Chr7:18946478-18946530 (+)	41 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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