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Gpr4 Gene Detail
Summary
  • Symbol
    Gpr4
  • Name
    G protein-coupled receptor 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441992
    NCBI Gene: 319197
  • Gene Overview
    MyGene.info: GPR4
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19212538-19224174 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    81 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441992
protein coding gene Chr7:19212499-19224176 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031765
protein coding gene Chr7:17179469-17191085 (+)
A/J MGP_AJ_G0031741
protein coding gene Chr7:16855261-16866825 (+)
AKR/J MGP_AKRJ_G0031667
protein coding gene Chr7:17312626-17324590 (+)
BALB/cJ MGP_BALBcJ_G0031746
protein coding gene Chr7:17056294-17067935 (+)
C3H/HeJ MGP_C3HHeJ_G0031468
protein coding gene Chr7:17580430-17592496 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032212
protein coding gene Chr7:18061245-18073002 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029278
protein coding gene Chr7:18501110-18513011 (+)
CAST/EiJ MGP_CASTEiJ_G0030811
protein coding gene Chr7:13984296-13995968 (+)
CBA/J MGP_CBAJ_G0031430
protein coding gene Chr7:18728740-18743141 (+)
DBA/2J MGP_DBA2J_G0031585
protein coding gene Chr7:16791708-16803871 (+)
FVB/NJ MGP_FVBNJ_G0031537
protein coding gene Chr7:16655271-16666729 (+)
LP/J MGP_LPJ_G0031668
protein coding gene Chr7:17518501-17530529 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031573
protein coding gene Chr7:18575787-18588361 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032240
protein coding gene Chr7:16922203-16933702 (+)
PWK/PhJ MGP_PWKPhJ_G0030535
protein coding gene Chr7:13880035-13893012 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030362
protein coding gene Chr7:11631254-11644390 (+)
WSB/EiJ MGP_WSBEiJ_G0030911
protein coding gene Chr7:17135279-17146924 (+)



Homology
more
  • Human Ortholog
    GPR4, G protein-coupled receptor 4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GPR4, G protein-coupled receptor 4
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 2828
    neXtProt AC: NX_P46093
    UniProt: P46093

  • Chr Location
    19q13.32; chr19:45589764-45602208 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 2 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display partial neonatal and postnatal lethality, hemorrhages, impaired association of vascular smooth muscle cells with capillaries and small arteries and veins, and impaired contact between mesangial cells and renal glomerular capillaries.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044317 Ensembl Gene Model | MGI Sequence Detail 11637 C57BL/6J ±  kb
    transcript ENSMUST00000060225 Ensembl | MGI Sequence Detail 2882 Not Applicable  
    polypeptide ENSMUSP00000061243 Ensembl | MGI Sequence Detail 365 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:255680 Sanderlin EJ, et al., GPR4 deficiency alleviates intestinal inflammation in a mouse model of acute experimental colitis. Biochim Biophys Acta. 2017 Feb;1863(2):569-584

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory