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Ghsr
Gene Detail
 Symbol
Name
ID
Ghsr
growth hormone secretagogue receptor
MGI:2441906
Synonyms C530020I22Rik
Feature Type protein coding gene
Genetic Map
Chromosome 3
10.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:27371351-27378010 bp, + strand
From NCBI annotation of GRCm38

  6660 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:57161  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: growth hormone secretagogue/motilin receptor
Gene Tree: Ghsr

Human
homologs
Human Homolog GHSR, growth hormone secretagogue receptor
NCBI Gene ID 2693
neXtProt AC  NX_Q92847
Human Chr (Location)  3q26.31; chr3:172443291-172448456 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GHSR
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homeostasis is disrupted by inactivation of this gene, namely growth hormone release and appetite stimulation.
 
Interactions
Ghsr interacts with 288 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process actin polymerization or depolymerization, adult feeding behavior, ...
Component cell, cell surface, ...
Function G-protein coupled receptor activity, growth hormone-releasing hormone receptor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (34)    Tissues (19)    Images (9)
Theiler Stages: 23
Assay TypeResults
RNA in situ 34
cDNA source data(6)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(6)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000051136 (Evidence)
Entrez Gene208188 (Evidence)
UniGene194721
DFCITC1599334, TC1669087
DoTSDT.91592257
NIA Mouse Gene IndexU003096
Consensus CDS ProjectCCDS17273.1
International Mouse Knockout Project StatusGhsr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 208188 NCBI Gene Model | MGI Sequence Detail 6660 C57BL/6J ±  kb
transcript NM_177330 RefSeq | MGI Sequence Detail 4433 C57BL/6 
polypeptide Q99P50 UniProt | EBI | MGI Sequence Detail 364 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(60 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR003905 Growth hormone secretagogue receptor type 1
Protein Ontology PR:000001225 growth hormone secretagogue receptor
Graphical View of Protein Domain Structure
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:209047 Heppner KM, et al., Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors. Diabetes. 2014 Jan;63(1):122-31
All references(71)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory