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Ghsr Gene Detail
Summary
  • Symbol
    Ghsr
  • Name
    growth hormone secretagogue receptor
  • Synonyms
    C530020I22Rik, Ghsr1a
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441906
    NCBI Gene: 208188
Location & Maps
more
  • Sequence Map
    Chr3:27371351-27378010 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6660 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 10.86 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GHSR, growth hormone secretagogue receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GHSR, growth hormone secretagogue receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GHDP
  • Links
    NCBI Gene ID: 2693
    neXtProt AC: NX_Q92847

  • Chr Location
    3q26.31; chr3:172443291-172448456 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 4 alleles in 4 genetic backgrounds
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Radiation induced
    1
  • Targeted
    9
  • Genomic Mutations
    1 involving Ghsr
  • Incidental Mutations
Homeostasis is disrupted by inactivation of this gene, namely growth hormone release and appetite stimulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051188 VEGA Gene Model | MGI Sequence Detail 6660 C57BL/6J ±  kb
transcript OTTMUST00000129643 VEGA | MGI Sequence Detail 4433 Not Applicable  
polypeptide OTTMUSP00000069617 VEGA | MGI Sequence Detail 364 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    60 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001225 growth hormone secretagogue receptor
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR003905 Growth hormone secretagogue receptor type 1
Molecular
Reagents
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  • All nucleic 6
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 90
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 61
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:229176 Xu G, et al., Ghrelin regulates GLP-1 production through mTOR signaling in L cells. Mol Cell Endocrinol. 2015 Nov 15;416:9-18

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory