Ghsr
Gene Detail

Symbol Name ID

Ghsr growth hormone secretagogue receptor MGI:2441906

Synonyms

C530020I22Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 3

10.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:27371351-27378010 bp, + strand From NCBI annotation of GRCm38   6660 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:57161  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: growth hormone secretagogue/motilin receptor
Gene Tree: Ghsr

Human homologs

Human Homolog		GHSR, growth hormone secretagogue receptor
NCBI Gene ID		2693
neXtProt AC		NX_Q92847
Human Chr (Location)		3q26.31; chr3:172161081-172166246 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GHSR

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Homeostasis is disrupted by inactivation of this gene, namely growth hormone release and appetite stimulation.

 

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	actin polymerization or depolymerization, adult feeding behavior, ...
Component	cell surface, integral to membrane, ...
Function	G-protein coupled receptor activity, growth hormone-releasing hormone receptor activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (34)    Tissues (19)    Images (9)
Theiler Stages: 23

Assay Type	Results
RNA in situ	34

cDNA source data(6)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(6)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000051136 (Evidence)
Entrez Gene	208188 (Evidence)
UniGene	194721
DFCI	TC1599334, TC1669087
DoTS	DT.91592257
NIA Mouse Gene Index	U003096
Consensus CDS Project	CCDS17273.1
International Mouse Knockout Project Status	Ghsr

Sequences

Length	Strain/Species
genomic	208188	NCBI Gene Model | MGI Sequence Detail	6660	C57BL/6J
transcript	NM_177330	RefSeq | MGI Sequence Detail	4433	C57BL/6
polypeptide	Q99P50	UniProt | EBI | MGI Sequence Detail	364	Not Applicable

All sequences(20) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(44 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR003905	Growth hormone secretagogue receptor, type 1
Protein Ontology	PR:000001225	growth hormone secretagogue receptor

Graphical View of Protein Domain Structure

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:193880 Lim CT, et al., Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism. Mol Cell Endocrinol. 2013 Jan 30;365(2):303-8
All references(67)