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Lpp
Gene Detail
Symbol

Name
ID
Lpp
LIM domain containing preferred translocation partner in lipoma
MGI:2441849
Synonyms
9430020K16Rik, B130055L10Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 16
16.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:24393350-24992576 bp, + strand
From Ensembl annotation of GRCm38

  599227 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4075  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LPP
Gene Tree: Lpp

Human
homologs
LPP, LIM domain containing preferred translocation partner in lipoma
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4026
neXtProt AC: NX_Q93052

Human Chr (Location): 3q28; chr3:188152143-188890671 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(84) : Gene trapped(82) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Gene disruption results in fertility problems involving females but not males. Migration and survival of MEFs are also abnormal.
 
Interactions
Lpp interacts with 636 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cell adhesion
Component cell junction, cytoplasm, ...
Function metal ion binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (38)    Tissues (37)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 30
RT-PCR 8
cDNA source data(31)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lpp ; ZFIN lpp    NEW 
Molecular
reagents
All nucleic(38) cDNA(37) Primer pair(1)
Microarray probesets(10)
Other database
links
Ensembl Gene Model ENSMUSG00000033306 (Evidence)
Entrez Gene 210126 (Evidence)
DFCI TC1641479, TC1623704, TC1620671, TC1610816, TC1602664, TC1574050, TC1623221, TC1652359, TC1606897, TC1586810, TC1591915, TC1589531, TC1588159
NIA Mouse Gene Index U149649, U016966
Consensus CDS Project CCDS28083.1, CCDS49807.1
International Mouse Phenotyping Consortium Status Lpp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033306 Ensembl Gene Model | MGI Sequence Detail 599227 C57BL/6J ±  kb
transcript ENSMUST00000078988 Ensembl | MGI Sequence Detail 15440 Not Applicable 
polypeptide ENSMUSP00000078005 Ensembl | MGI Sequence Detail 613 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(3332 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009902 lipoma-preferred partner
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:182886 Moik DV, et al., Loss of migfilin expression has no overt consequences on murine development and homeostasis. J Cell Sci. 2011 Feb 1;124(Pt 3):414-21
All references(43)
Other
accession IDs
MGI:2146367, MGI:2146570, MGI:2146704

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory