Lpp
Gene Detail

Symbol Name ID

Lpp LIM domain containing preferred translocation partner in lipoma MGI:2441849

Synonyms

9430020K16Rik, B130055L10Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 16

16.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:24393350-24992576 bp, + strand From Ensembl annotation of GRCm38   599227 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4075  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lpp

Human homologs

Human Homolog		LPP, LIM domain containing preferred translocation partner in lipoma
NCBI Gene ID		4026
neXtProt AC		NX_Q93052
Human Chr (Location)		3q28; chr3:187871663-188608460 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LPP

Alleles and phenotypes

All alleles(84) : Targeted(2) Gene trapped(82)
 

Gene disruption results in fertility problems involving females but not males. Migration and survival of MEFs are also abnormal.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	cell adhesion
Component	cell junction, cytoplasm, ...
Function	metal ion binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (45)    Tissues (42)    Images (5)
Theiler Stages: 2, 3, 4, 5, 17, 18, 21, 23, 28

Assay Type	Results
RNA in situ	30
RT-PCR	15

cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(38) cDNA(37) Primer pair(1)
Microarray probesets(10)

Other database links

Ensembl Gene Model	ENSMUSG00000033306 (Evidence)
Entrez Gene	210126 (Evidence)
DFCI	TC1574050, TC1586810, TC1588159, TC1589531, TC1591915, TC1602664, TC1606897, TC1610816, TC1620671, TC1623221, TC1623704, TC1641479, TC1652359
NIA Mouse Gene Index	U016966, U149649
Consensus CDS Project	CCDS28083.1, CCDS49807.1
International Mouse Knockout Project Status	Lpp

Sequences

Length	Strain/Species
genomic	ENSMUSG00000033306	Ensembl Gene Model | MGI Sequence Detail	599227	C57BL/6J
transcript	ENSMUST00000038053	Ensembl | MGI Sequence Detail	15647	Not Applicable
polypeptide	ENSMUSP00000036304	Ensembl | MGI Sequence Detail	613	Not Applicable

All sequences(77) RefSeq(6) UniProt(2)

Polymorphisms

SNPs(2554 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001781	Zinc finger, LIM-type
Protein Ontology	PR:000009902	lipoma-preferred partner

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:182886 Moik DV, et al., Loss of migfilin expression has no overt consequences on murine development and homeostasis. J Cell Sci. 2011 Feb 1;124(Pt 3):414-21
All references(44)

Other accession IDs

MGI:2146367, MGI:2146570, MGI:2146704