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Lpp Gene Detail
Summary
  • Symbol
    Lpp
  • Name
    LIM domain containing preferred translocation partner in lipoma
  • Synonyms
    9430020K16Rik, B130055L10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441849
    NCBI Gene: 210126
  • Gene Overview
    MyGene.info: LPP
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:24393350-24992576 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      599227 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 16.17 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LPP, LIM domain containing preferred translocation partner in lipoma
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LPP, LIM domain containing preferred translocation partner in lipoma
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 4026
    neXtProt AC: NX_Q93052
    UniProt: Q93052

  • Chr Location
    3q27.3-q28; chr3:188153050-188890671 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4075
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: LPP
  • Gene Tree
    Lpp
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene disruption results in fertility problems involving females but not males. Migration and survival of MEFs are also abnormal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033306 Ensembl Gene Model | MGI Sequence Detail 599227 C57BL/6J ±  kb
    transcript ENSMUST00000078988 Ensembl | MGI Sequence Detail 15440 Not Applicable  
    polypeptide ENSMUSP00000078005 Ensembl | MGI Sequence Detail 613 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      3331 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 37
      Primer pair 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:2146367, MGI:2146570, MGI:2146704
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 6
      Gene Ontology 3
      Phenotypes 12
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:242317 Tan J, et al., Lacking of palladin leads to multiple cellular events changes which contribute to NTD. Neural Dev. 2017 Mar 24;12(1):4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory