Tmem87a MGI Mouse Gene Detail - MGI:2441844

Symbol

Tmem87a
Name

transmembrane protein 87A
Synonyms

A930025J12Rik, Elkin1

Feature Type

protein coding gene
IDs

MGI:2441844
NCBI Gene: 211499
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:120185793-120234594 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 60.31 cM
Mapping Data

2 experiments

SNPs within 2kb

1050 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441844	protein coding gene	Chr2:120185790-120234597 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026365	protein coding gene	Chr2:123219859-123270949 (-)
A/J	MGP_AJ_G0026326	protein coding gene	Chr2:118169277-118217772 (-)
AKR/J	MGP_AKRJ_G0026305	protein coding gene	Chr2:121470290-121519421 (-)
BALB/cJ	MGP_BALBcJ_G0026339	protein coding gene	Chr2:118412891-118461720 (-)
C3H/HeJ	MGP_C3HHeJ_G0026085	protein coding gene	Chr2:121942629-121993639 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026786	protein coding gene	Chr2:127232952-127282648 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024166	protein coding gene	Chr2:113191196-113239181 (-)
CAST/EiJ	MGP_CASTEiJ_G0025547	protein coding gene	Chr2:122256394-122305682 (-)
CBA/J	MGP_CBAJ_G0026061	protein coding gene	Chr2:131687809-131737687 (-)
DBA/2J	MGP_DBA2J_G0026200	protein coding gene	Chr2:117559461-117607970 (-)
FVB/NJ	MGP_FVBNJ_G0026162	protein coding gene	Chr2:116395676-116443853 (-)
LP/J	MGP_LPJ_G0026301	protein coding gene	Chr2:123478896-123526717 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026181	protein coding gene	Chr2:135999152-136050632 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026841	protein coding gene	Chr2:121593510-121644906 (-)
PWK/PhJ	MGP_PWKPhJ_G0025283	protein coding gene	Chr2:117161054-117210381 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025082	protein coding gene	Chr2:120781917-120841221 (-)
WSB/EiJ	MGP_WSBEiJ_G0025616	protein coding gene	Chr2:122430234-122479032 (-)

Human Ortholog

TMEM87A, transmembrane protein 87A

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM87A, transmembrane protein 87A
Synonyms

ELKIN1, GOLPHCAT
Links

HGNC:24522

NCBI Gene ID: 25963

UniProt: Q8NBN3
Chr Location

15q15.1; chr15:42210447-42273584 (-) GRCh38

MGI Vertebrate Homology

Tmem87a stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TMEM87A
Gene Tree

Tmem87a

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

16
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Tmem87a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

56 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display loss of touch sensitivity.

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All GO Annotations

30
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

8
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem87a

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All Sequences

62
RefSeq

16
UniProt

4
CCDS

CCDS50677.1, CCDS50678.1

Ensembl

ENSMUSG00000033808 (Evidence)
NCBI Gene

211499

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033808	Ensembl Gene Model \| MGI Sequence Detail	48802	C57BL/6J	± kb
transcript	ENSMUST00000090046	Ensembl \| MGI Sequence Detail	2897	Not Applicable
polypeptide	ENSMUSP00000087500	Ensembl \| MGI Sequence Detail	560	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000029811 transmembrane protein 87A

(term hierarchy)
InterPro Domains

IPR009637 Transmembrane protein GPR107/GPR108-like
GlyGen

Q8BXN9 5 sites, 3 N-linked glycans (2 sites)

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All nucleic 9

cDNA 8

Primer pair 1

Microarray probesets 2

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 13
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:366423 Kang H, et al., GolpHCat (TMEM87A), a unique voltage-dependent cation channel in Golgi apparatus, contributes to Golgi-pH maintenance and hippocampus-dependent memory. Nat Commun. 2024 Jul 11;15(1):5830

TSS for Tmem87a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr25864	Chr2:120235169-120235184 (-)	-583 bp
Tssr25863	Chr2:120235088-120235134 (-)	-517 bp
Tssr25862	Chr2:120234584-120234596 (-)	4 bp
Tssr25861	Chr2:120234574-120234582 (-)	16 bp
Tssr25860	Chr2:120234539-120234573 (-)	38 bp
Tssr25859	Chr2:120199273-120199276 (-)	35,319 bp
Tssr25858	Chr2:120185969-120185972 (-)	48,623 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/24/2026 MGI 6.24