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Rxfp3 Gene Detail
Summary
  • Symbol
    Rxfp3
  • Name
    relaxin family peptide receptor 3
  • Synonyms
    Rln3r1, Salpr
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441827
    NCBI Gene: 239336
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr15:11033717-11037968 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 5.42 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    65 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441827
protein coding gene Chr15:11033717-11037991 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021729
protein coding gene Chr15:8204498-8208772 (-)
A/J MGP_AJ_G0021689
protein coding gene Chr15:7961274-7965552 (-)
AKR/J MGP_AKRJ_G0021667
protein coding gene Chr15:8158734-8163008 (-)
BALB/cJ MGP_BALBcJ_G0021696
protein coding gene Chr15:7864280-7868554 (-)
C3H/HeJ MGP_C3HHeJ_G0021472
protein coding gene Chr15:8112590-8116864 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022135
protein coding gene Chr15:8511801-8516075 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019672
protein coding gene Chr15:7433173-7437429 (-)
CAST/EiJ MGP_CASTEiJ_G0020988
protein coding gene Chr15:8168167-8172457 (-)
CBA/J MGP_CBAJ_G0021441
protein coding gene Chr15:8715771-8720045 (-)
DBA/2J MGP_DBA2J_G0021565
protein coding gene Chr15:7827329-7831603 (-)
FVB/NJ MGP_FVBNJ_G0021543
protein coding gene Chr15:7682254-7686532 (-)
LP/J MGP_LPJ_G0021633
protein coding gene Chr15:8108185-8112459 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021568
protein coding gene Chr15:8969500-8973774 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022158
protein coding gene Chr15:8137547-8141821 (-)
PWK/PhJ MGP_PWKPhJ_G0020731
protein coding gene Chr15:8000140-8004518 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020569
protein coding gene Chr15:8085236-8089505 (-)
WSB/EiJ MGP_WSBEiJ_G0021044
protein coding gene Chr15:8123177-8127469 (-)



Homology
more
  • Human Ortholog
    RXFP3, relaxin family peptide receptor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RXFP3, relaxin family peptide receptor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPCR135, RLN3R1, RXFPR3, SALPR
  • Links
    NCBI Gene ID: 51289
    neXtProt AC: NX_Q9NSD7
    UniProt: Q9NSD7

  • Chr Location
    5p13.2; chr5:33936386-33938918 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display a subtle decrease in anxiety related behaviors and hypoactivity in their home cages.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 239336 NCBI Gene Model | MGI Sequence Detail 4252 C57BL/6J ±  kb
transcript NM_178717 RefSeq | MGI Sequence Detail 4252 C57BL/6  
polypeptide Q8BGE9 UniProt | EBI | MGI Sequence Detail 472 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 1
References
more
  • Summaries
    All 30
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:242959 Walker AW, et al., Relaxin-3 receptor (Rxfp3) gene deletion reduces operant sucrose- but not alcohol-responding in mice. Genes Brain Behav. 2015 Nov;14(8):625-34

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory