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Cdc14b Gene Detail
Summary
  • Symbol
    Cdc14b
  • Name
    CDC14 cell division cycle 14B
  • Synonyms
    2810432N10Rik, A530086E13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441808
    NCBI Gene: 218294
  • Gene Overview
    MyGene.info: CDC14B
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:64192545-64274988 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 33.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1077 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441808
protein coding gene Chr13:64189268-64275290 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020676
protein coding gene Chr13:64212917-64296290 (-)
A/J MGP_AJ_G0020630
protein coding gene Chr13:61884570-61967253 (-)
AKR/J MGP_AKRJ_G0020607
protein coding gene Chr13:63934908-64018069 (-)
BALB/cJ MGP_BALBcJ_G0020628
protein coding gene Chr13:62301836-62385097 (-)
C3H/HeJ MGP_C3HHeJ_G0020423
protein coding gene Chr13:63457534-63541880 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021064
protein coding gene Chr13:66275123-66360769 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018640
protein coding gene Chr13:59530335-59617465 (-)
CAST/EiJ MGP_CASTEiJ_G0019940
protein coding gene Chr13:63468813-63554949 (-)
CBA/J MGP_CBAJ_G0020383
protein coding gene Chr13:68828152-68917610 (-)
DBA/2J MGP_DBA2J_G0020508
protein coding gene Chr13:61714140-61796971 (-)
FVB/NJ MGP_FVBNJ_G0020487
protein coding gene Chr13:60813987-60895273 (-)
LP/J MGP_LPJ_G0020582
protein coding gene Chr13:64489945-64576730 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020516
protein coding gene Chr13:67774229-67861163 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021106
protein coding gene Chr13:63245532-63331075 (-)
PWK/PhJ MGP_PWKPhJ_G0019694
protein coding gene Chr13:61275521-61358504 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019520
protein coding gene Chr13:61409975-61494275 (-)
WSB/EiJ MGP_WSBEiJ_G0020000
protein coding gene Chr13:63724205-63808001 (-)



Homology
more
  • Human Ortholog
    CDC14B, cell division cycle 14B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CDC14B, cell division cycle 14B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Cdc14B1, Cdc14B2, CDC14B3, hCDC14B
  • Links
    NCBI Gene ID: 8555
    neXtProt AC: NX_O60729
    UniProt: O60729

  • Chr Location
    9q22.32-q22.33; chr9:96492738-96619830 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit premature aging, including premature cataracts and kyphosis; reduced fertility, particularly in female mice; and impaired contextual conditioning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 218294 NCBI Gene Model | MGI Sequence Detail 82444 C57BL/6J ±  kb
    transcript NM_172587 RefSeq | MGI Sequence Detail 5859 C57BL/6  
    polypeptide Q6PFY9 UniProt | EBI | MGI Sequence Detail 485 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      Genomic 1
      cDNA 73

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1919423, MGI:3034490
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:257652 Imtiaz A, et al., CDC14A phosphatase is essential for hearing and male fertility in mouse and human. Hum Mol Genet. 2018 Mar 1;27(5):780-798

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory