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Cdc14b Gene Detail
Summary
  • Symbol
    Cdc14b
  • Name
    CDC14 cell division cycle 14B
  • Synonyms
    2810432N10Rik, A530086E13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441808
    NCBI Gene: 218294
  • Gene Overview
    MyGene.info: CDC14B
Location & Maps
more
  • Sequence Map
    Chr13:64192545-64274973 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      82429 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 33.26 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CDC14B, cell division cycle 14B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CDC14B, cell division cycle 14B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Cdc14B1, Cdc14B2, CDC14B3, hCDC14B
  • Links
    NCBI Gene ID: 8555
    neXtProt AC: NX_O60729

  • Chr Location
    9q22.3; chr9:96490218-96619830 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Targeted
    6
  • Genomic Mutations
    1 involving Cdc14b
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit premature aging, including premature cataracts and kyphosis; reduced fertility, particularly in female mice; and impaired contextual conditioning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033102 Ensembl Gene Model | MGI Sequence Detail 82429 C57BL/6J ±  kb
transcript ENSMUST00000039318 Ensembl | MGI Sequence Detail 5844 Not Applicable  
polypeptide ENSMUSP00000046003 Ensembl | MGI Sequence Detail 485 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1077 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000005185 dual specificity protein phosphatase CDC14B
  • EC
  • InterPro Domains
    IPR000340 Dual specificity phosphatase, catalytic domain
    IPR020422 Dual specificity protein phosphatase domain
    IPR029260 Dual specificity/tyrosine protein phosphatase, N-terminal
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR029021 Protein-tyrosine phosphatase-like
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
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  • All nucleic 73
    cDNA 73

    Microarray probesets 4
Other
Accession IDs
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MGI:1919423, MGI:3034490
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:228216 Lin H, et al., Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair. Mol Cell Biol. 2015 Nov;35(21):3657-68

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory