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Cdc14b Gene Detail
Summary
  • Symbol
    Cdc14b
  • Name
    CDC14 cell division cycle 14B
  • Synonyms
    2810432N10Rik, A530086E13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441808
    NCBI Gene: 218294
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:64337082-64423104 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 33.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1097 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441808
 protein coding gene Chr13:64337082-64423670 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020676
 protein coding gene Chr13:64212917-64296290 (-)
A/J MGP_AJ_G0020630
 protein coding gene Chr13:61884570-61967253 (-)
AKR/J MGP_AKRJ_G0020607
 protein coding gene Chr13:63934908-64018069 (-)
BALB/cJ MGP_BALBcJ_G0020628
 protein coding gene Chr13:62301836-62385097 (-)
C3H/HeJ MGP_C3HHeJ_G0020423
 protein coding gene Chr13:63457534-63541880 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021064
 protein coding gene Chr13:66275123-66360769 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018640
 protein coding gene Chr13:59530335-59617465 (-)
CAST/EiJ MGP_CASTEiJ_G0019940
 protein coding gene Chr13:63468813-63554949 (-)
CBA/J MGP_CBAJ_G0020383
 protein coding gene Chr13:68828152-68917610 (-)
DBA/2J MGP_DBA2J_G0020508
 protein coding gene Chr13:61714140-61796971 (-)
FVB/NJ MGP_FVBNJ_G0020487
 protein coding gene Chr13:60813987-60895273 (-)
LP/J MGP_LPJ_G0020582
 protein coding gene Chr13:64489945-64576730 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020516
 protein coding gene Chr13:67774229-67861163 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021106
 protein coding gene Chr13:63245532-63331075 (-)
PWK/PhJ MGP_PWKPhJ_G0019694
 protein coding gene Chr13:61275521-61358504 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019520
 protein coding gene Chr13:61409975-61494275 (-)
WSB/EiJ MGP_WSBEiJ_G0020000
 protein coding gene Chr13:63724205-63808001 (-)



Homology
more
  • Human Ortholog
    CDC14B, cell division cycle 14B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDC14B, cell division cycle 14B
  • Synonyms
    Cdc14B1, Cdc14B2, CDC14B3, hCDC14B
  • Links
    NCBI Gene ID: 8555
    neXtProt AC: NX_O60729
    UniProt: O60729

  • Chr Location
    9q22.32-q22.33; chr9:96490241-96619843 (-)  GRCh38
  • Human Ortholog
    CDC14C, cell division cycle 14C
  • Synonyms
    CDC14B2, CDC14Bretro
  • Links
    NCBI Gene ID: 168448
    UniProt: A4D256

  • Chr Location
    7p12.3; chr7:48924547-48927454 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit premature aging, including premature cataracts and kyphosis; reduced fertility, particularly in female mice; and impaired contextual conditioning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    73
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033102 Ensembl Gene Model | MGI Sequence Detail 86023 C57BL/6J ±  kb
    transcript ENSMUST00000221634 Ensembl | MGI Sequence Detail 1953 Not Applicable  
    polypeptide ENSMUSP00000152388 Ensembl | MGI Sequence Detail 492 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000005185 dual specificity protein phosphatase CDC14B
      (term hierarchy)
    • EC
      3.1.3.16, 3.1.3.48
    • InterPro Domains
      IPR000340 Dual specificity phosphatase, catalytic domain
      IPR044506 Dual-specificity phosphatase CDC14, C-terminal
      IPR020422 Dual specificity protein phosphatase domain
      IPR029260 Dual specificity/tyrosine protein phosphatase, N-terminal
      IPR016130 Protein-tyrosine phosphatase, active site
      IPR003595 Protein-tyrosine phosphatase, catalytic
      IPR029021 Protein-tyrosine phosphatase-like
      IPR000387 Tyrosine-specific protein phosphatases domain
    Molecular
    Reagents
    less
    • All nucleic 74
      Genomic 1
      cDNA 73

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1919423, MGI:3034490
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:291491 Bai GY, et al., Mis12 controls cyclin B1 stabilization via Cdc14B-mediated APC/C(Cdh1) regulation during meiotic G2/M transition in mouse oocytes. Development. 2020 Apr 27;147(8):dev185322
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory