About   Help   FAQ
Lgr6 Gene Detail
Summary
  • Symbol
    Lgr6
  • Name
    leucine-rich repeat-containing G protein-coupled receptor 6
  • Synonyms
    A530037C04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441805
    NCBI Gene: 329252
  • Gene Overview
    MyGene.info: LGR6
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:134983301-135105276 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 58.24 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1465 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441805
 protein coding gene Chr1:134983300-135105374 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016515
 protein coding gene Chr1:138710388-138840813 (-)
A/J MGP_AJ_G0016498
 protein coding gene Chr1:133471228-133595229 (-)
AKR/J MGP_AKRJ_G0016463
 protein coding gene Chr1:137450527-137575875 (-)
BALB/cJ MGP_BALBcJ_G0016458
 protein coding gene Chr1:133788275-133911215 (-)
C3H/HeJ MGP_C3HHeJ_G0016284
 protein coding gene Chr1:137542352-137669341 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016919
 protein coding gene Chr1:143733959-143864270 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014630
 protein coding gene Chr1:126586353-126709738 (-)
CAST/EiJ MGP_CASTEiJ_G0015864
 protein coding gene Chr1:136614571-136740789 (-)
CBA/J MGP_CBAJ_G0016257
 protein coding gene Chr1:148686502-148825361 (-)
DBA/2J MGP_DBA2J_G0016363
 protein coding gene Chr1:132475587-132599438 (-)
FVB/NJ MGP_FVBNJ_G0016362
 protein coding gene Chr1:131111796-131234820 (-)
LP/J MGP_LPJ_G0016434
 protein coding gene Chr1:139955128-140084021 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016387
 protein coding gene Chr1:154392807-154525521 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016955
 protein coding gene Chr1:137192072-137319050 (-)
PWK/PhJ MGP_PWKPhJ_G0015650
 protein coding gene Chr1:131497108-131621712 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015437
 protein coding gene Chr1:136157556-136282197 (-)
WSB/EiJ MGP_WSBEiJ_G0015927
 protein coding gene Chr1:137218742-137347659 (-)



Homology
more
  • Human Ortholog
    LGR6, leucine rich repeat containing G protein-coupled receptor 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LGR6, leucine rich repeat containing G protein-coupled receptor 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPCR, VTS20631
  • Links
    NCBI Gene ID: 59352
    neXtProt AC: NX_Q9HBX8
    UniProt: Q9HBX8

  • Chr Location
    1q32.1; chr1:202193990-202319761 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 1 genetic background
    31 phenotype references
Mice homozygous for a reporter/null allele are viable and fertile with no apparent abnormal phenotype. Similarly, mice homozygous for a knock-in allele are healthy and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    646
  • Tissues
    15
  • cDNA Data
    19
  • Literature Summary
    16
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042793 Ensembl Gene Model | MGI Sequence Detail 121976 C57BL/6J ±  kb
transcript ENSMUST00000044828 Ensembl | MGI Sequence Detail 6675 Not Applicable  
polypeptide ENSMUSP00000035444 Ensembl | MGI Sequence Detail 967 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001593 leucine-rich repeat-containing G-protein coupled receptor 6
    (term hierarchy)
  • InterPro Domains
    IPR002131 Glycoprotein hormone receptor family
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain superfamily
    IPR000372 Leucine-rich repeat N-terminal domain
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
less
  • All nucleic 23
    Genomic 2
    cDNA 19
    Primer pair 1
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 71
    Developmental Gene Expression 16
    Gene Ontology 5
    Phenotypes 31
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:290878 Sun X, et al., Coordinated hedgehog signaling induces new hair follicles in adult skin. Elife. 2020 Mar 17;9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
02/23/2021
MGI 6.16 		The Jackson Laboratory