Lgr6
Gene Detail

Symbol

Name
ID

Lgr6
leucine-rich repeat-containing G protein-coupled receptor 6
MGI:2441805

Synonyms

A530037C04Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 1
58.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:134983301-135105276 bp, - strand From VEGA annotation of GRCm38   121976 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:49680  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: leucine-rich repeat-containing G protein-coupled receptor 4/5/6
Gene Tree: Lgr6

Human
homologs

Human Homolog		LGR6, leucine-rich repeat containing G protein-coupled receptor 6
NCBI Gene ID		59352
neXtProt AC		NX_Q9HBX8
Human Synonyms		GPCR, VTS20631
Human Chr (Location)		1q32.1; chr1:202193810-202319761 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a reporter/null allele are viable and fertile with no apparent abnormal phenotype. Similarly, mice homozygous for a knock-in allele are healthy and fertile.

 

Interactions

Lgr6 interacts with 106 markers (Mir7b, Mir9-1, Mir9-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (17 annotations)

Process	G-protein coupled receptor signaling pathway, positive regulation of cell migration, ...
Component	cytoplasm, integral component of membrane, ...
Function	G-protein coupled receptor activity, protein-hormone receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)

cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(19) Genomic(1) cDNA(18)
Microarray probesets(2)

Other database
links

VEGA Gene Model	OTTMUSG00000026806 (Evidence)
Ensembl Gene Model	ENSMUSG00000042793 (Evidence)
Entrez Gene	329252 (Evidence)
UniGene	279594
DFCI	TC1598991, TC1583880
DoTS	DT.55167088, DT.87068058
NIA Mouse Gene Index	U021790
Consensus CDS Project	CCDS15314.1
International Mouse Knockout Project Status	Lgr6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026806	VEGA Gene Model | MGI Sequence Detail	121976	C57BL/6J
transcript	OTTMUST00000066294	VEGA | MGI Sequence Detail	6675	Not Applicable
polypeptide	OTTMUSP00000033204	VEGA | MGI Sequence Detail	967	Not Applicable

All sequences(36) RefSeq(6) UniProt(3)

Polymorphisms

SNPs within 2kb(1484 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR002131	Glycoprotein hormone receptor
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR000372	Leucine-rich repeat-containing N-terminal
InterPro	IPR003591	Leucine-rich repeat, typical subtype
Protein Ontology	PR:000001593	leucine-rich repeat-containing G-protein coupled receptor 6

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:216158 Rastetter RH, et al., Marker genes identify three somatic cell types in the fetal mouse ovary. Dev Biol. 2014 Oct 15;394(2):242-52
All references(37)