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Lgr6 Gene Detail
Summary
  • Symbol
    Lgr6
  • Name
    leucine-rich repeat-containing G protein-coupled receptor 6
  • Synonyms
    A530037C04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441805
    NCBI Gene: 329252
  • Gene Overview
    MyGene.info: LGR6
Location & Maps
more
  • Sequence Map
    Chr1:134983301-135105276 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      121976 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 58.24 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LGR6, leucine rich repeat containing G protein-coupled receptor 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LGR6, leucine rich repeat containing G protein-coupled receptor 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPCR, VTS20631
  • Links
    NCBI Gene ID: 59352
    neXtProt AC: NX_Q9HBX8

  • Chr Location
    1q32.1; chr1:202193990-202319785 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 1 genetic background
    14 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    3 involving Lgr6
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Mice homozygous for a reporter/null allele are viable and fertile with no apparent abnormal phenotype. Similarly, mice homozygous for a knock-in allele are healthy and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    15
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    4
  • Tissues
    4
  • cDNA Data
    18
  • Literature Summary
    5
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026806 VEGA Gene Model | MGI Sequence Detail 121976 C57BL/6J ±  kb
transcript OTTMUST00000066294 VEGA | MGI Sequence Detail 6675 Not Applicable  
polypeptide OTTMUSP00000033204 VEGA | MGI Sequence Detail 967 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1465 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001593 leucine-rich repeat-containing G-protein coupled receptor 6
  • InterPro Domains
    IPR002131 Glycoprotein hormone receptor family
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR000372 Leucine-rich repeat N-terminal domain
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
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  • All nucleic 20
    Genomic 1
    cDNA 18
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 37
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 14
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:233310 Wuidart A, et al., Quantitative lineage tracing strategies to resolve multipotency in tissue-specific stem cells. Genes Dev. 2016 Jun 1;30(11):1261-77
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory