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Shfl Gene Detail
Summary
  • Symbol
    Shfl
  • Name
    shiftless antiviral inhibitor of ribosomal frameshifting
  • Synonyms
    A230050P20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441788
    NCBI Gene: 319278
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:20779938-20785603 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.65 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    159 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441788
 protein coding gene Chr9:20779914-20785603 (+)
129S1/SvImJ ENSMUSG00200048100
 protein coding gene Chr9:17733721-17739386 (+)
A/J ENSMUSG00195033855
 protein coding gene Chr9:17570433-17576101 (+)
AKR/J ENSMUSG00220025398
 protein coding gene Chr9:17572900-17578567 (+)
BALB/cJ ENSMUSG00180036104
 protein coding gene Chr9:17698336-17704001 (+)
C3H/HeJ ENSMUSG00175035176
 protein coding gene Chr9:17667098-17672763 (+)
C57BL/6NJ ENSMUSG00215034756
 protein coding gene Chr9:17664613-17670280 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031848
 protein coding gene Chr9:16870935-16876838 (+)
CAST/EiJ ENSTCUG00005026157
 protein coding gene Chr9:17701933-17707611 (+)
CBA/J ENSMUSG00210034073
 protein coding gene Chr9:17647992-17653660 (+)
DBA/2J ENSMUSG00185026257
 protein coding gene Chr9:17763598-17769265 (+)
FVB/NJ ENSMUSG00205028064
 protein coding gene Chr9:17996460-18002126 (+)
JF1/MsJ ENSUMUG00000028198
 protein coding gene Chr9:17869400-17876616 (+)
LP/J ENSMUSG00230043231
 protein coding gene Chr9:18154989-18160652 (+)
NOD/ShiLtJ ENSMUSG00190022659
 protein coding gene Chr9:17688448-17694120 (+)
NZO/HlLtJ ENSMUSG00225050770
 protein coding gene Chr9:18105408-18111075 (+)
PWK/PhJ ENSLUMG00010045886
 protein coding gene Chr9:17759031-17766258 (+)
SPRET/EiJ ENSMSPG00010019439
 protein coding gene Chr9:17995178-18000819 (+)
WSB/EiJ ENSIUOG00005039179
 protein coding gene Chr9:17235356-17241011 (+)



Homology
more
  • Human Ortholog
    SHFL, shiftless antiviral inhibitor of ribosomal frameshifting
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SHFL, shiftless antiviral inhibitor of ribosomal frameshifting
  • Synonyms
    C19orf66, IRAV, RyDEN, SFL
  • Links
    NCBI Gene ID: 55337
    UniProt: Q9NUL5

  • Chr Location
    19p13.2; chr19:10086122-10093252 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    608
  • Tissues
    8
  • cDNA Data
    22
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038884 Ensembl Gene Model | MGI Sequence Detail 5666 C57BL/6J ±  kb
    transcript ENSMUST00000043911 Ensembl | MGI Sequence Detail 1683 Not Applicable  
    polypeptide ENSMUSP00000045384 Ensembl | MGI Sequence Detail 290 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000060111 shiftless antiviral inhibitor of ribosomal frameshifting protein
      (term hierarchy)
    • InterPro Domains
      IPR026795 Shiftless antiviral inhibitor of ribosomal frameshifting
    • GlyGen
      Q8CAK3 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 23

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:6296751
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory