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Eif5b Gene Detail
Summary
  • Symbol
    Eif5b
  • Name
    eukaryotic translation initiation factor 5B
  • Synonyms
    A030003E17Rik, IF2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441772
    NCBI Gene: 226982
  • Alliance
    gene page
  • Transcription Start Sites
    41 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:38037091-38094660 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 16.40 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1266 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441772
 protein coding gene Chr1:38037091-38094660 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015948
 protein coding gene Chr1:36656156-36718050 (+)
A/J MGP_AJ_G0015932
 protein coding gene Chr1:35645353-35702859 (+)
AKR/J MGP_AKRJ_G0015887
 protein coding gene Chr1:36136985-36200411 (+)
BALB/cJ MGP_BALBcJ_G0015886
 protein coding gene Chr1:35303935-35361844 (+)
C3H/HeJ MGP_C3HHeJ_G0015719
 protein coding gene Chr1:36364918-36429529 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016339
 protein coding gene Chr1:38245340-38309523 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014061
 protein coding gene Chr1:32629119-32689233 (+)
CAST/EiJ MGP_CASTEiJ_G0015300
 protein coding gene Chr1:36221940-36284709 (+)
CBA/J MGP_CBAJ_G0015691
 protein coding gene Chr1:39305993-39366294 (+)
DBA/2J MGP_DBA2J_G0015792
 protein coding gene Chr1:34949411-35008231 (+)
FVB/NJ MGP_FVBNJ_G0015794
 protein coding gene Chr1:34478564-34536983 (+)
LP/J MGP_LPJ_G0015862
 protein coding gene Chr1:37005299-37064355 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015814
 protein coding gene Chr1:41455519-41513888 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016386
 protein coding gene Chr1:36212394-36270950 (+)
PWK/PhJ MGP_PWKPhJ_G0015083
 protein coding gene Chr1:34737507-34795791 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014865
 protein coding gene Chr1:36167695-36218292 (+)
WSB/EiJ MGP_WSBEiJ_G0015362
 protein coding gene Chr1:36170336-36230122 (+)



Homology
more
  • Human Ortholog
    EIF5B, eukaryotic translation initiation factor 5B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF5B, eukaryotic translation initiation factor 5B
  • Synonyms
    IF2
  • Links
    NCBI Gene ID: 9669
    UniProt: O60841

  • Chr Location
    2q11.2; chr2:99337389-99401326 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show embryonic growth retardation and lethality before implantation. In vitro outgrowth assays show that embryos fail to hatch from the zona pellucida and die after 3 days in culture, never forming blastocysts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    21
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 226982 NCBI Gene Model | MGI Sequence Detail 57570 C57BL/6J ±  kb
transcript NM_198303 RefSeq | MGI Sequence Detail 7797 C57BL/6  
polypeptide Q05D44 UniProt | EBI | MGI Sequence Detail 1216 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000007006 eukaryotic translation initiation factor 5B
    (term hierarchy)
  • EC
    3.6.5.3
  • InterPro Domains
    IPR029459 Elongation factor Tu-type domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR005225 Small GTP-binding protein domain
    IPR000795 Translational (tr)-type GTP-binding domain
    IPR015760 Translation initiation factor IF- 2
    IPR023115 Translation initiation factor IF- 2, domain 3
    IPR036925 Translation initiation factor IF-2, domain 3 superfamily
    IPR009000 Translation protein, beta-barrel domain superfamily
  • GlyGen
    Q05D44 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 21
    cDNA 21

    Microarray probesets 5
Other
Accession IDs
less
MGI:2448517
References
more
  • Summaries
    All 43
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory