Eif5b Gene Detail

Summary

• Symbol
  Eif5b
• Name
  eukaryotic translation initiation factor 5B
• Synonyms
  A030003E17Rik, IF2

• Feature Type
  protein coding gene
• IDs
  MGI:2441772
  NCBI Gene: 226982
• Gene Overview
  MyGene.info: EIF5B
• Alliance
  gene page
• Transcription Start Sites
  16 TSS

Location &
Maps

• Sequence Map
  Chr1:37998010-38055579 bp, + strand
• From NCBI annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 16.40 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  307 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441772	protein coding gene	Chr1:37998010-38055579 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015948	protein coding gene	Chr1:36656156-36718050 (+)
A/J	MGP_AJ_G0015932	protein coding gene	Chr1:35645353-35702859 (+)
AKR/J	MGP_AKRJ_G0015887	protein coding gene	Chr1:36136985-36200411 (+)
BALB/cJ	MGP_BALBcJ_G0015886	protein coding gene	Chr1:35303935-35361844 (+)
C3H/HeJ	MGP_C3HHeJ_G0015719	protein coding gene	Chr1:36364918-36429529 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016339	protein coding gene	Chr1:38245340-38309523 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014061	protein coding gene	Chr1:32629119-32689233 (+)
CAST/EiJ	MGP_CASTEiJ_G0015300	protein coding gene	Chr1:36221940-36284709 (+)
CBA/J	MGP_CBAJ_G0015691	protein coding gene	Chr1:39305993-39366294 (+)
DBA/2J	MGP_DBA2J_G0015792	protein coding gene	Chr1:34949411-35008231 (+)
FVB/NJ	MGP_FVBNJ_G0015794	protein coding gene	Chr1:34478564-34536983 (+)
LP/J	MGP_LPJ_G0015862	protein coding gene	Chr1:37005299-37064355 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015814	protein coding gene	Chr1:41455519-41513888 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016386	protein coding gene	Chr1:36212394-36270950 (+)
PWK/PhJ	MGP_PWKPhJ_G0015083	protein coding gene	Chr1:34737507-34795791 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014865	protein coding gene	Chr1:36167695-36218292 (+)
WSB/EiJ	MGP_WSBEiJ_G0015362	protein coding gene	Chr1:36170336-36230122 (+)

Homology

• Human Ortholog
  EIF5B, eukaryotic translation initiation factor 5B

• Vertebrate Orthologs
  10

• Human Ortholog
  EIF5B, eukaryotic translation initiation factor 5B
  Orthology source: HomoloGene, HGNC
• Synonyms
  IF2
• Links
  HGNC:30793

  NCBI Gene ID: 9669

  neXtProt AC: NX_O60841

  UniProt: O60841

  
  
• Chr Location
  2q11.2; chr2:99337371-99400265 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 134613
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: EIF5B
• Gene Tree
  Eif5b
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotype references
  

• All Mutations and Alleles
  31
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Gene trapped
  29
• Genomic Mutations
  1 involving Eif5b
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  16 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  13
• GO References
  4

• External Resources
  FuncBase

Expression

• cDNA Data
  21

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA EIF5B
  Xenbase eif5b
  ZFIN eif5b

Interactions

• Eif5b interacts with 451 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

Sequences &
Gene Models

• All Sequences
  56
• RefSeq
  2
• UniProt
  5
• CCDS
  CCDS35544.1

• Ensembl
  ENSMUSG00000026083 (Evidence)
• NCBI Gene
  226982

Representative Sequences			Length	Strain/Species
genomic	226982	NCBI Gene Model | MGI Sequence Detail	57570	C57BL/6J
transcript	NM_198303	RefSeq | MGI Sequence Detail	7797	C57BL/6
polypeptide	Q05D44	UniProt | EBI | MGI Sequence Detail	1216	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000007006 eukaryotic translation initiation factor 5B
  (term hierarchy)
• EC
  3.6.5.3
• InterPro Domains
  IPR027417 P-loop containing nucleoside triphosphate hydrolase
  IPR005225 Small GTP-binding protein domain
  IPR000795 Transcription factor, GTP-binding domain
  IPR004161 Translation elongation factor EFTu-like, domain 2
  IPR015760 Translation initiation factor IF- 2
  IPR023115 Translation initiation factor IF- 2, domain 3
  IPR036925 Translation initiation factor IF-2, domain 3 superfamily
  IPR009000 Translation protein, beta-barrel domain superfamily

Molecular
Reagents

• All nucleic 21

  cDNA 21

  
  

  Microarray probesets 5

Other
Accession IDs

MGI:2448517

References

• Summaries
  All 34

  Gene Ontology 4

  Phenotypes 8
• Earliest
  J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
• Latest
  J:216452 Lee S, et al., Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):E4315-22

TSS for Eif5b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6328	Chr1:37997956-37997963 (+)	-50 bp
Tssr6329	Chr1:37997975-37997986 (+)	-29 bp
Tssr49	Chr1:37997987-37997994 (+)	-19 bp
Tssr6330	Chr1:37998005-37998014 (+)	0 bp
Tssr6331	Chr1:37998097-37998114 (+)	96 bp
Tssr6332	Chr1:37998115-37998149 (+)	122 bp
Tssr6333	Chr1:37998152-37998165 (+)	149 bp
Tssr50	Chr1:37998187-37998199 (+)	183 bp
Tssr51	Chr1:37998255-37998273 (+)	254 bp
Tssr52	Chr1:37998294-37998297 (+)	286 bp
Tssr6334	Chr1:37998774-37998777 (+)	766 bp
Tssr6335	Chr1:38017848-38017862 (+)	19,845 bp
Tssr6336	Chr1:38017865-38017877 (+)	19,861 bp
Tssr6337	Chr1:38018046-38018060 (+)	20,043 bp
Tssr6338	Chr1:38018067-38018084 (+)	20,066 bp
Tssr6363	Chr1:38042777-38042791 (+)	44,774 bp