Eif5b MGI Mouse Gene Detail - MGI:2441772 - eukaryotic translation initiation factor 5B

Symbol

Eif5b
Name

eukaryotic translation initiation factor 5B
Synonyms

A030003E17Rik, IF2

Feature Type

protein coding gene
IDs

MGI:2441772
NCBI Gene: 226982
Gene Overview

MyGene.info: EIF5B
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr1:37998010-38055579 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 16.40 cM
Mapping Data

2 experiments

SNPs within 2kb

307 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441772	protein coding gene	Chr1:37998010-38055579 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015948	protein coding gene	Chr1:36656156-36718050 (+)
A/J	MGP_AJ_G0015932	protein coding gene	Chr1:35645353-35702859 (+)
AKR/J	MGP_AKRJ_G0015887	protein coding gene	Chr1:36136985-36200411 (+)
BALB/cJ	MGP_BALBcJ_G0015886	protein coding gene	Chr1:35303935-35361844 (+)
C3H/HeJ	MGP_C3HHeJ_G0015719	protein coding gene	Chr1:36364918-36429529 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016339	protein coding gene	Chr1:38245340-38309523 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014061	protein coding gene	Chr1:32629119-32689233 (+)
CAST/EiJ	MGP_CASTEiJ_G0015300	protein coding gene	Chr1:36221940-36284709 (+)
CBA/J	MGP_CBAJ_G0015691	protein coding gene	Chr1:39305993-39366294 (+)
DBA/2J	MGP_DBA2J_G0015792	protein coding gene	Chr1:34949411-35008231 (+)
FVB/NJ	MGP_FVBNJ_G0015794	protein coding gene	Chr1:34478564-34536983 (+)
LP/J	MGP_LPJ_G0015862	protein coding gene	Chr1:37005299-37064355 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015814	protein coding gene	Chr1:41455519-41513888 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016386	protein coding gene	Chr1:36212394-36270950 (+)
PWK/PhJ	MGP_PWKPhJ_G0015083	protein coding gene	Chr1:34737507-34795791 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014865	protein coding gene	Chr1:36167695-36218292 (+)
WSB/EiJ	MGP_WSBEiJ_G0015362	protein coding gene	Chr1:36170336-36230122 (+)

Human Ortholog

EIF5B, eukaryotic translation initiation factor 5B

Vertebrate Orthologs

10

Human Ortholog

EIF5B, eukaryotic translation initiation factor 5B
Orthology source: HomoloGene, HGNC
Synonyms

IF2
Links

HGNC:30793

NCBI Gene ID: 9669

neXtProt AC: NX_O60841

UniProt: O60841
Chr Location

2q11.2; chr2:99337371-99400265 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 134613
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: EIF5B
Gene Tree

Eif5b

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Phenotype Summary

8 phenotype references

All Mutations and Alleles

31
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

29
Genomic Mutations

1 involving Eif5b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

46 strains or lines available

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All GO Annotations

13
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
cDNA Data

21

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA EIF5B

Xenbase eif5b

ZFIN eif5b

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Eif5b interacts with 451 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

58
RefSeq

4
UniProt

5
CCDS

CCDS35544.1

Ensembl

ENSMUSG00000026083 (Evidence)
NCBI Gene

226982

			Length	Strain/Species	Flank
genomic	226982	NCBI Gene Model \| MGI Sequence Detail	57570	C57BL/6J	± kb
transcript	NM_198303	RefSeq \| MGI Sequence Detail	7797	C57BL/6
polypeptide	Q05D44	UniProt \| EBI \| MGI Sequence Detail	1216	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007006 eukaryotic translation initiation factor 5B

(term hierarchy)
EC

3.6.5.3
InterPro Domains

IPR029459 Elongation factor Tu-type domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR005225 Small GTP-binding protein domain

IPR000795 Translational (tr)-type GTP-binding domain

IPR004161 Translation elongation factor EFTu-like, domain 2

IPR015760 Translation initiation factor IF- 2

IPR023115 Translation initiation factor IF- 2, domain 3

IPR036925 Translation initiation factor IF-2, domain 3 superfamily

IPR009000 Translation protein, beta-barrel domain superfamily

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All nucleic 21

cDNA 21

Microarray probesets 5

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MGI:2448517

Summaries

All 34

Gene Ontology 4

Phenotypes 8
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:216452 Lee S, et al., Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):E4315-22

TSS for Eif5b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6328	Chr1:37997956-37997963 (+)	-50 bp
Tssr6329	Chr1:37997975-37997986 (+)	-29 bp
Tssr49	Chr1:37997987-37997994 (+)	-19 bp
Tssr6330	Chr1:37998005-37998014 (+)	0 bp
Tssr6331	Chr1:37998097-37998114 (+)	96 bp
Tssr6332	Chr1:37998115-37998149 (+)	122 bp
Tssr6333	Chr1:37998152-37998165 (+)	149 bp
Tssr50	Chr1:37998187-37998199 (+)	183 bp
Tssr51	Chr1:37998255-37998273 (+)	254 bp
Tssr52	Chr1:37998294-37998297 (+)	286 bp
Tssr6334	Chr1:37998774-37998777 (+)	766 bp
Tssr6335	Chr1:38017848-38017862 (+)	19,845 bp
Tssr6336	Chr1:38017865-38017877 (+)	19,861 bp
Tssr6337	Chr1:38018046-38018060 (+)	20,043 bp
Tssr6338	Chr1:38018067-38018084 (+)	20,066 bp
Tssr6363	Chr1:38042777-38042791 (+)	44,774 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/05/2021 MGI 6.16