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Eif5b Gene Detail
Summary
  • Symbol
    Eif5b
  • Name
    eukaryotic translation initiation factor 5B
  • Synonyms
    A030003E17Rik, IF2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441772
    NCBI Gene: 226982
  • Gene Overview
    MyGene.info: EIF5B
Location & Maps
more
  • Sequence Map
    Chr1:37998010-38055579 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      57570 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 16.40 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    EIF5B, eukaryotic translation initiation factor 5B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EIF5B, eukaryotic translation initiation factor 5B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IF2
  • Links
    NCBI Gene ID: 9669
    neXtProt AC: NX_O60841

  • Chr Location
    2q11.2; chr2:99337371-99400265 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 134613
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: EIF5B
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    30
  • Chemically induced (other)
    1
  • Gene trapped
    29
  • Genomic Mutations
    1 involving Eif5b
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049483 VEGA Gene Model | MGI Sequence Detail 57570 C57BL/6J ±  kb
transcript OTTMUST00000126162 VEGA | MGI Sequence Detail 7797 Not Applicable  
polypeptide OTTMUSP00000068278 VEGA | MGI Sequence Detail 1216 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    307 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000007006 eukaryotic translation initiation factor 5B
  • EC
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR005225 Small GTP-binding protein domain
    IPR000795 Transcription factor, GTP-binding domain
    IPR004161 Translation elongation factor EFTu-like, domain 2
    IPR023115 Translation initiation factor IF- 2, domain 3
    IPR009000 Translation protein, beta-barrel domain
Molecular
Reagents
less
  • All nucleic 21
    cDNA 20
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2448517
References
more
  • Summaries
    All 30
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:216452 Lee S, et al., Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):E4315-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory