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Eif5b Gene Detail
Summary
  • Symbol
    Eif5b
  • Name
    eukaryotic translation initiation factor 5B
  • Synonyms
    A030003E17Rik, IF2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441772
    NCBI Gene: 226982
  • Gene Overview
    MyGene.info: EIF5B
  • Alliance
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:37998010-38055579 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 16.40 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    307 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441772
protein coding gene Chr1:37998010-38055579 (.)
129S1/SvImJ MGP_129S1SvImJ_G0015948
protein coding gene Chr1:36656156-36718050 (+)
A/J MGP_AJ_G0015932
protein coding gene Chr1:35645353-35702859 (+)
AKR/J MGP_AKRJ_G0015887
protein coding gene Chr1:36136985-36200411 (+)
BALB/cJ MGP_BALBcJ_G0015886
protein coding gene Chr1:35303935-35361844 (+)
C3H/HeJ MGP_C3HHeJ_G0015719
protein coding gene Chr1:36364918-36429529 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016339
protein coding gene Chr1:38245340-38309523 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014061
protein coding gene Chr1:32629119-32689233 (+)
CAST/EiJ MGP_CASTEiJ_G0015300
protein coding gene Chr1:36221940-36284709 (+)
CBA/J MGP_CBAJ_G0015691
protein coding gene Chr1:39305993-39366294 (+)
DBA/2J MGP_DBA2J_G0015792
protein coding gene Chr1:34949411-35008231 (+)
FVB/NJ MGP_FVBNJ_G0015794
protein coding gene Chr1:34478564-34536983 (+)
LP/J MGP_LPJ_G0015862
protein coding gene Chr1:37005299-37064355 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015814
protein coding gene Chr1:41455519-41513888 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016386
protein coding gene Chr1:36212394-36270950 (+)
PWK/PhJ MGP_PWKPhJ_G0015083
protein coding gene Chr1:34737507-34795791 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014865
protein coding gene Chr1:36167695-36218292 (+)
WSB/EiJ MGP_WSBEiJ_G0015362
protein coding gene Chr1:36170336-36230122 (+)



Homology
more
  • Human Ortholog
    EIF5B, eukaryotic translation initiation factor 5B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EIF5B, eukaryotic translation initiation factor 5B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IF2
  • Links
    NCBI Gene ID: 9669
    neXtProt AC: NX_O60841
    UniProt: O60841

  • Chr Location
    2q11.2; chr2:99337371-99400265 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 134613
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EIF5B
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 226982 NCBI Gene Model | MGI Sequence Detail 57570 C57BL/6J ±  kb
transcript NM_198303 RefSeq | MGI Sequence Detail 7797 C57BL/6  
polypeptide Q05D44 UniProt | EBI | MGI Sequence Detail 1216 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000007006 eukaryotic translation initiation factor 5B
  • EC
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR005225 Small GTP-binding protein domain
    IPR000795 Transcription factor, GTP-binding domain
    IPR004161 Translation elongation factor EFTu-like, domain 2
    IPR015760 Translation initiation factor IF- 2
    IPR023115 Translation initiation factor IF- 2, domain 3
    IPR036925 Translation initiation factor IF-2, domain 3 superfamily
    IPR009000 Translation protein, beta-barrel domain superfamily
Molecular
Reagents
less
  • All nucleic 21
    cDNA 21

    Microarray probesets 5
Other
Accession IDs
less
MGI:2448517
References
more
  • Summaries
    All 34
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:216452 Lee S, et al., Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):E4315-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory