Eif5b Gene Detail

Summary

• Symbol
  Eif5b
• Name
  eukaryotic translation initiation factor 5B
• Synonyms
  A030003E17Rik, IF2

• Feature Type
  protein coding gene
• IDs
  MGI:2441772
  NCBI Gene: 226982
• Gene Overview
  MyGene.info: EIF5B
• Alliance
  gene page

Location & Maps

• Sequence Map
  Chr1:37998010-38055579 bp, + strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    57570 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 16.40 cM
• Mapping Data
  2 experiments

Homology

• Human Ortholog
  EIF5B, eukaryotic translation initiation factor 5B

• Vertebrate Orthologs
  10

• Human Ortholog
  EIF5B, eukaryotic translation initiation factor 5B
  Orthology source: HomoloGene, HGNC
• Synonyms
  IF2
• Links
  HGNC:30793

  NCBI Gene ID: 9669

  neXtProt AC: NX_O60841

  UniProt: O60841

  
  
• Chr Location
  2q11.2; chr2:99337371-99400265 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 134613
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: EIF5B
• Gene Tree
  Eif5b
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotype references
  

• All Mutations and Alleles
  30
• Chemically induced (other)
  1
• Gene trapped
  29
• Genomic Mutations
  1 involving Eif5b
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  41 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  11
• GO References
  3

• External Resources
  FuncBase

Expression

• cDNA Data
  20

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA EIF5B
  Xenbase eif5b
  ZFIN eif5b

Interactions

• Eif5b interacts with 451 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

Sequences &
Gene Models

• All Sequences
  45
• RefSeq
  2
• UniProt
  5
• CCDS
  CCDS35544.1

• VEGA
  OTTMUSG00000049483 (Evidence)
• Ensembl
  ENSMUSG00000026083 (Evidence)
• NCBI Gene
  226982

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000049483	VEGA Gene Model | MGI Sequence Detail	57570	C57BL/6J
transcript	OTTMUST00000126162	VEGA | MGI Sequence Detail	7797	Not Applicable
polypeptide	OTTMUSP00000068278	VEGA | MGI Sequence Detail	1216	Not Applicable

Polymorphisms

• SNPs within 2kb
  307 from dbSNP Build 142

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000007006 eukaryotic translation initiation factor 5B
  (term hierarchy)
• EC
  3.6.5.3
• InterPro Domains
  IPR027417 P-loop containing nucleoside triphosphate hydrolase
  IPR005225 Small GTP-binding protein domain
  IPR000795 Transcription factor, GTP-binding domain
  IPR004161 Translation elongation factor EFTu-like, domain 2
  IPR015760 Translation initiation factor IF- 2
  IPR023115 Translation initiation factor IF- 2, domain 3
  IPR036925 Translation initiation factor IF-2, domain 3 superfamily
  IPR009000 Translation protein, beta-barrel domain superfamily

Molecular
Reagents

• All nucleic 20

  cDNA 20

  
  

  Microarray probesets 5

Other
Accession IDs

MGI:2448517

References

• Summaries
  All 32

  Gene Ontology 3

  Phenotypes 7
• Earliest
  J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
• Latest
  J:216452 Lee S, et al., Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):E4315-22