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Nmur2 Gene Detail
Summary
  • Symbol
    Nmur2
  • Name
    neuromedin U receptor 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441765
    NCBI Gene: 216749
  • Gene Overview
    MyGene.info: NMUR2
Location & Maps
more
  • Sequence Map
    Chr11:56024987-56041010 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16024 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 33.39 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NMUR2, neuromedin U receptor 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NMUR2, neuromedin U receptor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FM4, FM-4, NMU2R, NMU-R2, TGR1, TGR-1
  • Links
    NCBI Gene ID: 56923
    neXtProt AC: NX_Q9GZQ4

  • Chr Location
    5q33.1; chr5:152391541-152405281 (-)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    2 involving Nmur2
  • Incidental Mutations
Mice homozygous for one knock-out allele exhibit increased chemical and thermal nociception thresholds, insensitivity to treatment with Nmu or Nms, and altered weight gain following a fast or when fed a high-fat diet that can be sex-dependent.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005700 VEGA Gene Model | MGI Sequence Detail 16024 C57BL/6J ±  kb
transcript OTTMUST00000012682 VEGA | MGI Sequence Detail 3302 Not Applicable  
polypeptide OTTMUSP00000005875 VEGA | MGI Sequence Detail 395 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    161 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 2
References
more
  • Summaries
    All 26
    Diseases 1
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory