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Npsr1 Gene Detail
Summary
  • Symbol
    Npsr1
  • Name
    neuropeptide S receptor 1
  • Synonyms
    9330128H10Rik, Gpr154, PGR14, VRR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441738
    NCBI Gene: 319239
  • Gene Overview
    MyGene.info: NPSR1
Location & Maps
more
  • Sequence Map
    Chr9:24097996-24316398 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      218403 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 9.99 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NPSR1, neuropeptide S receptor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NPSR1, neuropeptide S receptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASRT2, GPR154, GPRA, NPSR, PGR14, VRR1
  • Links
    NCBI Gene ID: 387129
    neXtProt AC: NX_Q6W5P4

  • Chr Location
    7p14.3; chr7:34658239-34878332 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human NPSR1 associations

Human Disease Mouse Models
       Asthma-Related Traits, Susceptibility to, 2   OMIM: 608584
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Gene trapped
    1
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit decreased airway resistance when treated with high concentrations of U-46619.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024228 VEGA Gene Model | MGI Sequence Detail 218403 C57BL/6J ±  kb
transcript OTTMUST00000059289 VEGA | MGI Sequence Detail 3791 Not Applicable  
polypeptide OTTMUSP00000028831 VEGA | MGI Sequence Detail 371 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1289 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000001491 neuropeptide S receptor
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR027294 Neuropeptide S receptor
    IPR001817 Vasopressin receptor
Molecular
Reagents
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  • All nucleic 9
    cDNA 7
    Other 2

    Microarray probesets 1
References
more
  • Summaries
    All 30
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:207647 Pulga A, et al., Anxiolytic- and panicolytic-like effects of Neuropeptide S in the mouse elevated T-maze. Eur J Neurosci. 2012 Dec;36(11):3531-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory