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Npsr1 Gene Detail
Summary
  • Symbol
    Npsr1
  • Name
    neuropeptide S receptor 1
  • Synonyms
    9330128H10Rik, Gpr154, PGR14, VRR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441738
    NCBI Gene: 319239
  • Gene Overview
    MyGene.info: NPSR1
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr9:24097996-24316398 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 9.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1289 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441738
protein coding gene Chr9:24097950-24317590 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034491
protein coding gene Chr9:21440747-21660507 (+)
A/J MGP_AJ_G0034469
protein coding gene Chr9:21036300-21246366 (+)
AKR/J MGP_AKRJ_G0034395
protein coding gene Chr9:21436273-21642562 (+)
BALB/cJ MGP_BALBcJ_G0034460
protein coding gene Chr9:20909914-21128723 (+)
C3H/HeJ MGP_C3HHeJ_G0034172
protein coding gene Chr9:21763234-21980426 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034981
protein coding gene Chr9:22315476-22552729 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031911
protein coding gene Chr9:20026107-20237910 (+)
CAST/EiJ MGP_CASTEiJ_G0033494
protein coding gene Chr9:21594451-21829691 (+)
CBA/J MGP_CBAJ_G0034145
protein coding gene Chr9:23116080-23339365 (+)
DBA/2J MGP_DBA2J_G0034303
protein coding gene Chr9:21005821-21218966 (+)
FVB/NJ MGP_FVBNJ_G0034246
protein coding gene Chr9:20508380-20724976 (+)
LP/J MGP_LPJ_G0034389
protein coding gene Chr9:21648935-21880453 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034290
protein coding gene Chr9:24695494-24936171 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035001
protein coding gene Chr9:21397104-21621415 (+)
PWK/PhJ MGP_PWKPhJ_G0033200
protein coding gene Chr9:20956339-21168598 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033034
protein coding gene Chr9:21411858-21641854 (+)
WSB/EiJ MGP_WSBEiJ_G0033610
protein coding gene Chr9:21141888-21362494 (+)



Homology
more
  • Human Ortholog
    NPSR1, neuropeptide S receptor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NPSR1, neuropeptide S receptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASRT2, GPR154, GPRA, NPSR, PGR14, VRR1
  • Links
    NCBI Gene ID: 387129
    neXtProt AC: NX_Q6W5P4
    UniProt: Q6W5P4

  • Chr Location
    7p14.3; chr7:34658239-34878332 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased airway resistance when treated with high concentrations of U-46619.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043659 Ensembl Gene Model | MGI Sequence Detail 218403 C57BL/6J ±  kb
transcript ENSMUST00000059650 Ensembl | MGI Sequence Detail 3791 Not Applicable  
polypeptide ENSMUSP00000056432 Ensembl | MGI Sequence Detail 371 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 1
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory