About   Help   FAQ
Eno4 Gene Detail
Summary
  • Symbol
    Eno4
  • Name
    enolase 4
  • Synonyms
    6430537H07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441717
    NCBI Gene: 226265
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:58943425-58971421 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 54.55 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    296 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441717
protein coding gene Chr19:58934058-58971421 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025283
protein coding gene Chr19:59437452-59468059 (+)
A/J MGP_AJ_G0025259
protein coding gene Chr19:56533624-56560926 (+)
AKR/J MGP_AKRJ_G0025228
protein coding gene Chr19:58297809-58325042 (+)
BALB/cJ MGP_BALBcJ_G0025254
protein coding gene Chr19:56602966-56630766 (+)
C3H/HeJ MGP_C3HHeJ_G0025014
protein coding gene Chr19:58549647-58581312 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025697
protein coding gene Chr19:60878709-60909257 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023109
protein coding gene Chr19:55416733-55442429 (+)
CAST/EiJ MGP_CASTEiJ_G0024479
protein coding gene Chr19:58632916-58661379 (+)
CBA/J MGP_CBAJ_G0024994
protein coding gene Chr19:63851420-63883028 (+)
DBA/2J MGP_DBA2J_G0025126
protein coding gene Chr19:56280641-56307382 (+)
FVB/NJ MGP_FVBNJ_G0025087
protein coding gene Chr19:56021768-56047314 (+)
LP/J MGP_LPJ_G0025212
protein coding gene Chr19:59317086-59349932 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025120
protein coding gene Chr19:63078511-63114581 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025755
protein coding gene Chr19:58530579-58560433 (+)
PWK/PhJ MGP_PWKPhJ_G0024227
protein coding gene Chr19:56281953-56311130 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024030
protein coding gene Chr19:57198329-57226335 (+)
WSB/EiJ MGP_WSBEiJ_G0024549
protein coding gene Chr19:58649170-58676395 (+)



Homology
more
  • Human Ortholog
    ENO4, enolase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ENO4, enolase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C10orf134
  • Links
    NCBI Gene ID: 387712
    neXtProt AC: NX_A6NNW6
    UniProt: A6NNW6

  • Chr Location
    10q25.3; chr10:116848230-116911803 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 18691
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ENO4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit male infertility associated with abnormal sperm morphology, number and motility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048029 Ensembl Gene Model | MGI Sequence Detail 27997 C57BL/6J ±  kb
    transcript ENSMUST00000054280 Ensembl | MGI Sequence Detail 2568 Not Applicable  
    polypeptide ENSMUSP00000062584 Ensembl | MGI Sequence Detail 619 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 5
    References
    more
    • Summaries
      All 20
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 3
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:202075 Nakamura N, et al., Disruption of a spermatogenic cell-specific mouse enolase 4 (eno4) gene causes sperm structural defects and male infertility. Biol Reprod. 2013 Apr;88(4):90

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    02/11/2020
    MGI 6.14
    The Jackson Laboratory