About   Help   FAQ
Supv3l1 Gene Detail
Summary
  • Symbol
    Supv3l1
  • Name
    suppressor of var1, 3-like 1 (S. cerevisiae)
  • Synonyms
    6330443E10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441711
    NCBI Gene: 338359
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:62264988-62285517 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.40 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    489 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441711
 protein coding gene Chr10:62264988-62287294 (-)
129S1/SvImJ ENSMUSG00200026549
 protein coding gene Chr10:58937577-58958108 (-)
A/J ENSMUSG00195025051
 protein coding gene Chr10:59244902-59265431 (-)
AKR/J ENSMUSG00220037724
 protein coding gene Chr10:58938241-58958768 (-)
BALB/cJ ENSMUSG00180023912
 protein coding gene Chr10:59287197-59307726 (-)
C3H/HeJ ENSMUSG00175025013
 protein coding gene Chr10:59144794-59165323 (-)
C57BL/6NJ ENSMUSG00215019615
 protein coding gene Chr10:58885324-58905853 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015383
 protein coding gene Chr10:56934174-56954313 (-)
CAST/EiJ ENSTCUG00005025786
 protein coding gene Chr10:58939799-58960299 (-)
CBA/J ENSMUSG00210032402
 protein coding gene Chr10:59023103-59043632 (-)
DBA/2J ENSMUSG00185037587
 protein coding gene Chr10:59364668-59385193 (-)
FVB/NJ ENSMUSG00205021545
 protein coding gene Chr10:59038249-59058781 (-)
JF1/MsJ ENSUMUG00000011138
 protein coding gene Chr10:60601007-60621603 (-)
LP/J ENSMUSG00230014221
 protein coding gene Chr10:61167625-61188154 (-)
NOD/ShiLtJ ENSMUSG00190025666
 protein coding gene Chr10:59350282-59370811 (-)
NZO/HlLtJ ENSMUSG00225044133
 protein coding gene Chr10:65448599-65469128 (-)
PWK/PhJ ENSLUMG00010020961
 protein coding gene Chr10:58983632-59004271 (-)
SPRET/EiJ ENSMSPG00010023110
 protein coding gene Chr10:60554479-60574001 (-)
WSB/EiJ ENSIUOG00005039444
 protein coding gene Chr10:58919681-58940206 (-)



Homology
more
  • Human Ortholog
    SUPV3L1, Suv3 like RNA helicase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SUPV3L1, Suv3 like RNA helicase
  • Synonyms
    SUV3
  • Links
    NCBI Gene ID: 6832
    UniProt: Q8IYB8

  • Chr Location
    10q22.1; chr10:69180234-69209108 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 7 alleles in 8 genetic backgrounds
    5 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele exhibit embryonic lethality between E9.5 and E12.5. Mice homozygous for a knock-out allele exhibit embryonic lethality between E8.5 and 9.5. Mice heterozygous for this allele produce offspring with mitochondrial defects regardless of offspring genotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    81
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    658
  • Tissues
    40
  • cDNA Data
    7
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020079 Ensembl Gene Model | MGI Sequence Detail 20530 C57BL/6J ±  kb
    transcript ENSMUST00000020273 Ensembl | MGI Sequence Detail 2604 Not Applicable  
    polypeptide ENSMUSP00000020273 Ensembl | MGI Sequence Detail 779 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000015839 ATP-dependent RNA helicase SUPV3L1, mitochondrial
      (term hierarchy)
    • EC
      3.6.4.13
    • InterPro Domains
      IPR050699 ATP-dependent RNA helicase SUPV3-like
      IPR022192 ATP-dependent RNA helicase SUV3, C-terminal domain
      IPR055206 ATP-dependent RNA helicase SUV3, DEXQ-box helicase domain
      IPR001650 Helicase, C-terminal domain-like
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR041082 Suv3, C-terminal domain 1
      IPR044774 Suv3, DEXQ-box helicase domain
      IPR041453 Suv3, N-terminal
    • GlyGen
      Q80YD1 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7
      Antibodies 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 21
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory