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Supv3l1
Gene Detail
 Symbol
Name
ID
Supv3l1
suppressor of var1, 3-like 1 (S. cerevisiae)
MGI:2441711
Synonyms 6330443E10Rik
Feature Type protein coding gene
Genetic Map
Chromosome 10
32.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:62429209-62449738 bp, - strand
From VEGA annotation of GRCm38

  20530 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2386  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Supv3l1

Human
homologs
Human Homolog SUPV3L1, suppressor of var1, 3-like 1 (S. cerevisiae)
NCBI Gene ID 6832
neXtProt AC  NX_Q8IYB8
Human Synonyms  SUV3
Human Chr (Location)  10q22.1; chr10:69180237-69209098 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(5) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a hypomorphic allele exhibit embryonic lethality between E9.5 and E12.5. Mice homozygous for a knock-out allele exhibit embryonic lethality between E8.5 and 9.5. Mice heterozygous for this allele produce offspring with mitochondrial defects regardless of offspring genotype.
 
Phenotype Images(5)
Interactions
Supv3l1 interacts with 52 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process ATP catabolic process, chromatin maintenance, ...
Component mitochondrial degradosome, mitochondrial matrix, ...
Function 3'-5' RNA helicase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (61)    Tissues (40)   
Theiler Stages: 1, 2, 5, 11, 15, 19, 21, 24, 27, 28
Assay TypeResults
In situ reporter (knock in) 56
Western blot 5
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(6)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000017268 (Evidence)
Ensembl Gene ModelENSMUSG00000020079 (Evidence)
Entrez Gene338359 (Evidence)
EC3.6.4.13
Consensus CDS ProjectCCDS35920.1
International Mouse Knockout Project StatusSupv3l1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017268 VEGA Gene Model | MGI Sequence Detail 20530 C57BL/6J ±  kb
transcript OTTMUST00000041801 VEGA | MGI Sequence Detail 2604 Not Applicable 
polypeptide OTTMUSP00000018795 VEGA | MGI Sequence Detail 779 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(101 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001650 Helicase, C-terminal
InterPro IPR022192 Mitochondrial degradasome RNA helicase subunit, C-terminal domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000015839 ATP-dependent RNA helicase SUPV3L1, mitochondrial
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:193361 Chen PL, et al., Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan. Oncogene. 2013 Feb 28;32(9):1193-201
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory