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Traf3ip3 Gene Detail
Summary
  • Symbol
    Traf3ip3
  • Name
    TRAF3 interacting protein 3
  • Synonyms
    6030423D04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441706
    NCBI Gene: 215243
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:192857812-192883854 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 97.62 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    753 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441706
 protein coding gene Chr1:192857761-192884011 (-)
129S1/SvImJ ENSMUSG00200003711
 protein coding gene Chr1:190631369-190653997 (-)
A/J ENSMUSG00195008384
 protein coding gene Chr1:190205406-190228040 (-)
AKR/J ENSMUSG00220004768
 protein coding gene Chr1:189457579-189480206 (-)
BALB/cJ ENSMUSG00180017680
 protein coding gene Chr1:190279554-190302177 (-)
C3H/HeJ ENSMUSG00175020794
 protein coding gene Chr1:190458629-190481259 (-)
C57BL/6NJ ENSMUSG00215016222
 protein coding gene Chr1:189693599-189716227 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015067
 protein coding gene Chr1:182900574-182927710 (-)
CAST/EiJ ENSTCUG00005001805
 protein coding gene Chr1:188238255-188260744 (-)
CBA/J ENSMUSG00210003234
 protein coding gene Chr1:190143348-190165952 (-)
DBA/2J ENSMUSG00185010341
 protein coding gene Chr1:194744066-194766672 (-)
FVB/NJ ENSMUSG00205003494
 protein coding gene Chr1:189118766-189141400 (-)
JF1/MsJ ENSUMUG00000007236
 protein coding gene Chr1:193704820-193727616 (-)
LP/J ENSMUSG00230002092
 protein coding gene Chr1:194269550-194292172 (-)
NOD/ShiLtJ ENSMUSG00190029447
 protein coding gene Chr1:190096555-190119187 (-)
NZO/HlLtJ ENSMUSG00225015601
 protein coding gene Chr1:198014863-198037465 (-)
PWK/PhJ ENSLUMG00010006033
 protein coding gene Chr1:188958663-188981293 (-)
SPRET/EiJ ENSMSPG00010023992
 protein coding gene Chr1:192470515-192496654 (-)
WSB/EiJ ENSIUOG00005004598
 protein coding gene Chr1:189438619-189461260 (-)



Homology
more
  • Human Ortholog
    TRAF3IP3, TRAF3 interacting protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRAF3IP3, TRAF3 interacting protein 3
  • Synonyms
    T3JAM
  • Links
    NCBI Gene ID: 80342
    UniProt: Q9Y228

  • Chr Location
    1q32.2; chr1:209756032-209782320 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired single positive thymocyte development and increased gamma-delta T cell numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    705
  • Tissues
    14
  • cDNA Data
    34
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 215243 NCBI Gene Model | MGI Sequence Detail 26043 C57BL/6J ±  kb
transcript NM_153137 RefSeq | MGI Sequence Detail 2142 C57BL/6  
polypeptide Q8C0G2 UniProt | EBI | MGI Sequence Detail 513 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    cDNA 38

    Microarray probesets 4
Other
Accession IDs
less
MGI:2138156
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory