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Tlk1 Gene Detail
Summary
  • Symbol
    Tlk1
  • Name
    tousled-like kinase 1
  • Synonyms
    4930545J15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441683
    NCBI Gene: 228012
  • Gene Overview
    MyGene.info: TLK1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:70712407-70825728 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 41.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    246 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441683
protein coding gene Chr2:70712407-70825816 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025816
protein coding gene Chr2:70772299-70888741 (-)
A/J MGP_AJ_G0025793
protein coding gene Chr2:68018373-68136583 (-)
AKR/J MGP_AKRJ_G0025762
protein coding gene Chr2:69875739-69995919 (-)
BALB/cJ MGP_BALBcJ_G0025788
protein coding gene Chr2:68207423-68321267 (-)
C3H/HeJ MGP_C3HHeJ_G0025548
protein coding gene Chr2:70089856-70206039 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026235
protein coding gene Chr2:72896984-73014071 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023638
protein coding gene Chr2:65250797-65362332 (-)
CAST/EiJ MGP_CASTEiJ_G0025012
protein coding gene Chr2:70262968-70381199 (-)
CBA/J MGP_CBAJ_G0025528
protein coding gene Chr2:75595877-75718440 (-)
DBA/2J MGP_DBA2J_G0025659
protein coding gene Chr2:67652544-67765248 (-)
FVB/NJ MGP_FVBNJ_G0025622
protein coding gene Chr2:67035556-67148959 (-)
LP/J MGP_LPJ_G0025748
protein coding gene Chr2:70620795-70739195 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025651
protein coding gene Chr2:77614890-77733876 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026292
protein coding gene Chr2:69964158-70082328 (-)
PWK/PhJ MGP_PWKPhJ_G0024753
protein coding gene Chr2:67512488-67627680 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024560
protein coding gene Chr2:70168135-70280712 (-)
WSB/EiJ MGP_WSBEiJ_G0025080
protein coding gene Chr2:70401912-70517128 (-)



Homology
more
  • Human Ortholog
    TLK1, tousled like kinase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TLK1, tousled like kinase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PKU-beta
  • Links
    NCBI Gene ID: 9874
    neXtProt AC: NX_Q9UKI8
    UniProt: Q9UKI8

  • Chr Location
    2q31.1; chr2:170990823-171231314 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 130657
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TLK1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041997 Ensembl Gene Model | MGI Sequence Detail 113322 C57BL/6J ±  kb
transcript ENSMUST00000038584 Ensembl | MGI Sequence Detail 4280 Not Applicable  
polypeptide ENSMUSP00000035961 Ensembl | MGI Sequence Detail 766 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 130
    cDNA 129
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 34
    Gene Ontology 3
    Phenotypes 14
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:260159 Lee J, et al., Tousled-like kinase 1 is a negative regulator of core transcription factors in murine embryonic stem cells. Sci Rep. 2018 Jan 10;8(1):334

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory