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Tlk1 Gene Detail
Summary
  • Symbol
    Tlk1
  • Name
    tousled-like kinase 1
  • Synonyms
    4930545J15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441683
    NCBI Gene: 228012
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:70542751-70656072 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 41.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    243 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441683
 protein coding gene Chr2:70542751-70656505 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025816
 protein coding gene Chr2:70772299-70888741 (-)
A/J MGP_AJ_G0025793
 protein coding gene Chr2:68018373-68136583 (-)
AKR/J MGP_AKRJ_G0025762
 protein coding gene Chr2:69875739-69995919 (-)
BALB/cJ MGP_BALBcJ_G0025788
 protein coding gene Chr2:68207423-68321267 (-)
C3H/HeJ MGP_C3HHeJ_G0025548
 protein coding gene Chr2:70089856-70206039 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026235
 protein coding gene Chr2:72896984-73014071 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023638
 protein coding gene Chr2:65250797-65362332 (-)
CAST/EiJ MGP_CASTEiJ_G0025012
 protein coding gene Chr2:70262968-70381199 (-)
CBA/J MGP_CBAJ_G0025528
 protein coding gene Chr2:75595877-75718440 (-)
DBA/2J MGP_DBA2J_G0025659
 protein coding gene Chr2:67652544-67765248 (-)
FVB/NJ MGP_FVBNJ_G0025622
 protein coding gene Chr2:67035556-67148959 (-)
LP/J MGP_LPJ_G0025748
 protein coding gene Chr2:70620795-70739195 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025651
 protein coding gene Chr2:77614890-77733876 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026292
 protein coding gene Chr2:69964158-70082328 (-)
PWK/PhJ MGP_PWKPhJ_G0024753
 protein coding gene Chr2:67512488-67627680 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024560
 protein coding gene Chr2:70168135-70280712 (-)
WSB/EiJ MGP_WSBEiJ_G0025080
 protein coding gene Chr2:70401912-70517128 (-)



Homology
more
  • Human Ortholog
    TLK1, tousled like kinase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLK1, tousled like kinase 1
  • Synonyms
    PKU-beta
  • Links
    NCBI Gene ID: 9874
    neXtProt AC: NX_Q9UKI8
    UniProt: Q9UKI8

  • Chr Location
    2q31.1; chr2:170990823-171231314 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    16 phenotype references
Mice homozygous for a knock-out allele are viable and fertile with no overt phenotypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    31
  • cDNA Data
    129
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041997 Ensembl Gene Model | MGI Sequence Detail 113322 C57BL/6J ±  kb
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 130
    cDNA 129
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 16
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:309786 Song YF, et al., The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF signaling pathway. Free Radic Biol Med. 2020 Aug 1;155:69-80
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/10/2022
MGI 6.19 		The Jackson Laboratory