Tlk1 Gene Detail

Summary

• Symbol
  Tlk1
• Name
  tousled-like kinase 1
• Synonyms
  4930545J15Rik

• Feature Type
  protein coding gene
• IDs
  MGI:2441683
  NCBI Gene: 228012
• Gene Overview
  MyGene.info: TLK1

Location & Maps

• Sequence Map
  Chr2:70712407-70825728 bp, - strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    113322 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 2, 41.90 cM
• Mapping Data
  2 experiments

Homology

• Human Ortholog
  TLK1, tousled like kinase 1

• Vertebrate Orthologs
  9

• Human Ortholog
  TLK1, tousled like kinase 1
  Orthology source: HomoloGene, HGNC
• Synonyms
  PKU-beta
• Links
  HGNC:11841

  NCBI Gene ID: 9874

  neXtProt AC: NX_Q9UKI8

  
  
• Chr Location
  2q31.1; chr2:170990823-171231314 (-)  GRCh38.p2

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• HomoloGene
  Vertebrate Homology Class 130657
  1 human;1 mouse;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  
• HCOP
  human homology predictions: TLK1
• Gene Tree
  Tlk1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  14 phenotype references
  

• All Mutations and Alleles
  257
• Chemically induced (other)
  1
• Gene trapped
  253
• Targeted
  3
• Genomic Mutations
  1 involving Tlk1
• Incidental Mutations
  Mutagenetix , APF

Gene Ontology
(GO)
Classifications

• All GO Annotations
  16
• GO References
  3

• External Resources
  FuncBase

Expression

• cDNA Data
  128

• Other Mouse Links
  Allen Institute
  GEO
• Other Vertebrate Links
  Xenbase tlk1

Interactions

• Tlk1 interacts with 271 markers (Mir7-1, Mir7b, Mir9-1, ...) View All

Sequences &
Gene Models

• All Sequences
  51
• RefSeq
  17
• UniProt
  3
• CCDS
  CCDS50599.1
• UniGene
  136511

• VEGA
  OTTMUSG00000013119 (Evidence)
• Ensembl
  ENSMUSG00000041997 (Evidence)
• NCBI Gene
  228012

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000013119	VEGA Gene Model | MGI Sequence Detail	113322	C57BL/6J
transcript	OTTMUST00000031668	VEGA | MGI Sequence Detail	4280	Not Applicable
polypeptide	OTTMUSP00000014110	VEGA | MGI Sequence Detail	766	Not Applicable

Polymorphisms

• SNPs within 2kb
  246 from dbSNP Build 142

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000016377 serine/threonine-protein kinase tousled-like 1
• EC
  2.7.11.1
• InterPro Domains
  IPR017441 Protein kinase, ATP binding site
  IPR000719 Protein kinase domain
  IPR011009 Protein kinase-like domain
  IPR008271 Serine/threonine-protein kinase, active site

Molecular
Reagents

• All nucleic 129

  cDNA 128

  Primer pair 1

  
  

  Microarray probesets 5

References

• Summaries
  All 31

  Gene Ontology 3

  Phenotypes 14
• Earliest
  J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
• Latest
  J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582