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Tlk1 Gene Detail
Summary
  • Symbol
    Tlk1
  • Name
    tousled-like kinase 1
  • Synonyms
    4930545J15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441683
    NCBI Gene: 228012
  • Gene Overview
    MyGene.info: TLK1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr2:70712407-70825728 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      113322 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 41.90 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TLK1, tousled like kinase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TLK1, tousled like kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PKU-beta
  • Links
    NCBI Gene ID: 9874
    neXtProt AC: NX_Q9UKI8
    UniProt: Q9UKI8

  • Chr Location
    2q31.1; chr2:170990823-171231314 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 130657
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TLK1
  • Gene Tree
    Tlk1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    129
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013119 VEGA Gene Model | MGI Sequence Detail 113322 C57BL/6J ±  kb
transcript OTTMUST00000031668 VEGA | MGI Sequence Detail 4280 Not Applicable  
polypeptide OTTMUSP00000014110 VEGA | MGI Sequence Detail 766 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    246 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 130
    cDNA 129
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 34
    Gene Ontology 3
    Phenotypes 14
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/09/2018
MGI 6.12 		The Jackson Laboratory