Tlk1 MGI Mouse Gene Detail - MGI:2441683

Symbol

Tlk1
Name

tousled-like kinase 1
Synonyms

4930545J15Rik

Feature Type

protein coding gene
IDs

MGI:2441683
NCBI Gene: 228012
Gene Overview

MyGene.info: TLK1
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:70712407-70825728 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 41.90 cM
Mapping Data

2 experiments

SNPs within 2kb

246 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2441683	protein coding gene	Chr2:70712407-70825816 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025816	protein coding gene	Chr2:70772299-70888741 (-)
A/J	MGP_AJ_G0025793	protein coding gene	Chr2:68018373-68136583 (-)
AKR/J	MGP_AKRJ_G0025762	protein coding gene	Chr2:69875739-69995919 (-)
BALB/cJ	MGP_BALBcJ_G0025788	protein coding gene	Chr2:68207423-68321267 (-)
C3H/HeJ	MGP_C3HHeJ_G0025548	protein coding gene	Chr2:70089856-70206039 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026235	protein coding gene	Chr2:72896984-73014071 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023638	protein coding gene	Chr2:65250797-65362332 (-)
CAST/EiJ	MGP_CASTEiJ_G0025012	protein coding gene	Chr2:70262968-70381199 (-)
CBA/J	MGP_CBAJ_G0025528	protein coding gene	Chr2:75595877-75718440 (-)
DBA/2J	MGP_DBA2J_G0025659	protein coding gene	Chr2:67652544-67765248 (-)
FVB/NJ	MGP_FVBNJ_G0025622	protein coding gene	Chr2:67035556-67148959 (-)
LP/J	MGP_LPJ_G0025748	protein coding gene	Chr2:70620795-70739195 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025651	protein coding gene	Chr2:77614890-77733876 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026292	protein coding gene	Chr2:69964158-70082328 (-)
PWK/PhJ	MGP_PWKPhJ_G0024753	protein coding gene	Chr2:67512488-67627680 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024560	protein coding gene	Chr2:70168135-70280712 (-)
WSB/EiJ	MGP_WSBEiJ_G0025080	protein coding gene	Chr2:70401912-70517128 (-)

Human Ortholog

TLK1, tousled like kinase 1

Vertebrate Orthologs

9

Human Ortholog

TLK1, tousled like kinase 1
Orthology source: HomoloGene, HGNC
Synonyms

PKU-beta
Links

HGNC:11841

NCBI Gene ID: 9874

neXtProt AC: NX_Q9UKI8

UniProt: Q9UKI8
Chr Location

2q31.1; chr2:170990823-171231314 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 130657
1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: TLK1
Gene Tree

Tlk1

less

Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
4 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

257
Chemically induced (other)

1
Gene trapped

253
Targeted

3
Genomic Mutations

1 involving Tlk1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

195 strains or lines available

Mice homozygous for a knock-out allele are viable and fertile with no overt phenotypes.

less

All GO Annotations

22
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
cDNA Data

129
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tlk1

less

Tlk1 interacts with 271 markers (Mir7-1, Mir7b, Mir9-1, ...) View All

less

All Sequences

62
RefSeq

19
UniProt

3
CCDS

CCDS50599.1
UniGene

136511

Ensembl

ENSMUSG00000041997 (Evidence)
NCBI Gene

228012

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041997	Ensembl Gene Model \| MGI Sequence Detail	113322	C57BL/6J	± kb
transcript	ENSMUST00000038584	Ensembl \| MGI Sequence Detail	4280	Not Applicable
polypeptide	ENSMUSP00000035961	Ensembl \| MGI Sequence Detail	766	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000016377 serine/threonine-protein kinase tousled-like 1

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

less

All nucleic 130

cDNA 129

Primer pair 1

Microarray probesets 5

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 16
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:260159 Lee J, et al., Tousled-like kinase 1 is a negative regulator of core transcription factors in murine embryonic stem cells. Sci Rep. 2018 Jan 10;8(1):334

TSS for Tlk1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr24465	Chr2:70825894-70825934 (-)	-186 bp
Tssr24464	Chr2:70825726-70825820 (-)	-45 bp
Tssr24463	Chr2:70825674-70825725 (-)	28 bp
Tssr24462	Chr2:70825578-70825618 (-)	130 bp
Tssr24461	Chr2:70825484-70825524 (-)	224 bp
Tssr24460	Chr2:70825403-70825455 (-)	299 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 07/29/2020 MGI 6.15