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Abcc12 Gene Detail
Summary
  • Symbol
    Abcc12
  • Name
    ATP-binding cassette, sub-family C member 12
  • Synonyms
    4930467B22Rik, MRP9
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441679
    NCBI Gene: 244562
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:87231197-87307317 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 42.06 cM, cytoband D3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2292 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441679
 protein coding gene Chr8:87208889-87307317 (-)
129S1/SvImJ ENSMUSG00200017039
 protein coding gene Chr8:81576546-81638448 (-)
A/J ENSMUSG00195027499
 protein coding gene Chr8:81944334-82006374 (-)
AKR/J ENSMUSG00220032808
 protein coding gene Chr8:81975367-82037300 (-)
BALB/cJ ENSMUSG00180021207
 protein coding gene Chr8:81780016-81841930 (-)
C3H/HeJ ENSMUSG00175023806
 protein coding gene Chr8:81879935-81941965 (-)
C57BL/6NJ ENSMUSG00215012516
 protein coding gene Chr8:81497928-81559968 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031344
 protein coding gene Chr8:78059135-78149293 (-)
CAST/EiJ ENSTCUG00005015866
 protein coding gene Chr8:81353652-81415816 (-)
CBA/J ENSMUSG00210032196
 protein coding gene Chr8:81867050-81929094 (-)
DBA/2J ENSMUSG00185035125
 protein coding gene Chr8:87975603-88037641 (-)
FVB/NJ ENSMUSG00205025762
 protein coding gene Chr8:80927236-80989283 (-)
JF1/MsJ ENSUMUG00000021666
 protein coding gene Chr8:90278111-90341002 (-)
LP/J ENSMUSG00230030569
 protein coding gene Chr8:91573444-91635337 (-)
NOD/ShiLtJ ENSMUSG00190013150
 protein coding gene Chr8:81952926-82014949 (-)
NZO/HlLtJ ENSMUSG00225039283
 protein coding gene Chr8:94988808-95050838 (-)
PWK/PhJ ENSLUMG00010033442
 protein coding gene Chr8:81602012-81665377 (-)
SPRET/EiJ ENSMSPG00010025878
 protein coding gene Chr8:83527258-83595764 (-)
WSB/EiJ ENSIUOG00005017993
 protein coding gene Chr8:82673687-82735703 (-)



Homology
more
  • Human Ortholog
    ABCC12, ATP binding cassette subfamily C member 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABCC12, ATP binding cassette subfamily C member 12
  • Synonyms
    MRP9
  • Links
    NCBI Gene ID: 94160
    UniProt: Q96J65

  • Chr Location
    16q12.1; chr16:48080882-48156018 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display bile duct paucity with elevated ALT and ALP levels and increased sensitivity to cholic acid induced liver damage and weight loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    119
  • cDNA Data
    18
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 244562 NCBI Gene Model | MGI Sequence Detail 76121 C57BL/6J ±  kb
    transcript NM_172912 RefSeq | MGI Sequence Detail 4862 C57BL/6  
    polypeptide Q80WJ6 UniProt | EBI | MGI Sequence Detail 1366 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000003557 ATP-binding cassette sub-family C member 12
      (term hierarchy)
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR003439 ABC transporter-like, ATP-binding domain
      IPR017871 ABC transporter-like, conserved site
      IPR011527 ABC transporter type 1, transmembrane domain
      IPR036640 ABC transporter type 1, transmembrane domain superfamily
      IPR050173 ATP-binding cassette transporter C-like
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      Q80WJ6 2 sites
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 18
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 38
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory