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Hcar1 Gene Detail
Summary
  • Symbol
    Hcar1
  • Name
    hydrocarboxylic acid receptor 1
  • Synonyms
    Gpr81
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441671
    NCBI Gene: 243270
  • Gene Overview
    MyGene.info: HCAR1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:123876736-123880020 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3285 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 63.24 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HCAR1, hydroxycarboxylic acid receptor 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    HCAR1, hydroxycarboxylic acid receptor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FKSG80, GPR104, GPR81, HCA1, LACR1, TAGPCR, TA-GPCR
  • Links
    NCBI Gene ID: 27198
    neXtProt AC: NX_Q9BXC0
    UniProt: Q9BXC0

  • Chr Location
    12q24.31; chr12:122727606-122730582 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Hcar1
  • Find Mice (IMSR)
Mice homozygous for a knock-out allele exhibit resistance to lactate-induced suppression of lipolysis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037966 VEGA Gene Model | MGI Sequence Detail 3285 C57BL/6J ±  kb
transcript OTTMUST00000097859 VEGA | MGI Sequence Detail 3285 Not Applicable  
polypeptide OTTMUSP00000054883 VEGA | MGI Sequence Detail 351 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    36 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR028016 Hydroxycarboxylic acid receptor 1
Molecular
Reagents
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  • All nucleic 18
    cDNA 15
    Primer pair 2
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:258427 Ranganathan P, et al., GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis. J Immunol. 2018 Mar 1;200(5):1781-1789

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/18/2018
MGI 6.12
The Jackson Laboratory