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Gbp5 Gene Detail
Summary
  • Symbol
    Gbp5
  • Name
    guanylate binding protein 5
  • Synonyms
    5330409J06Rik, Gbp5a
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429943
    NCBI Gene: 229898
  • Gene Overview
    MyGene.info: GBP5
Location & Maps
more
  • Sequence Map
    Chr3:142493978-142522344 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28367 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 66.69 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GBP5, guanylate binding protein 5
  • Vertebrate Orthologs
    6
  • Human Ortholog
    GBP5, guanylate binding protein 5
    Orthology source: HomoloGene
  • Synonyms
    GBP-5
  • Links
    NCBI Gene ID: 115362
    neXtProt AC: NX_Q96PP8

  • Chr Location
    1p22.2; chr1:89258950-89272861 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Endonuclease-mediated
    2
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Gbp5
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit increased susceptibility to Listeria infection and NLRP3 inflammation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053926 VEGA Gene Model | MGI Sequence Detail 28367 C57BL/6J ±  kb
transcript OTTMUST00000134132 VEGA | MGI Sequence Detail 3756 Not Applicable  
polypeptide OTTMUSP00000071186 VEGA | MGI Sequence Detail 724 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    274 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000007878 guanylate-binding protein 5
  • EC
  • InterPro Domains
    IPR030386 GB1/RHD3-type guanine nucleotide-binding (G) domain
    IPR003191 Guanylate-binding protein, C-terminal
    IPR015894 Guanylate-binding protein, N-terminal
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 17
    cDNA 17

    Microarray probesets 1
Other
Accession IDs
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MGI:2444553
References
more
  • Summaries
    All 29
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:79318 Smith JB, et al., Glucocorticoid-attenuated response genes induced in the lung during endotoxemia. Am J Physiol Lung Cell Mol Physiol. 2002 Sep;283(3):L636-47
  • Latest
    J:210626 Meunier E, et al., Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases. Nature. 2014 May 15;509(7500):366-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory