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Gbp5 Gene Detail
Summary
  • Symbol
    Gbp5
  • Name
    guanylate binding protein 5
  • Synonyms
    5330409J06Rik, Gbp5a
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429943
    NCBI Gene: 229898
  • Gene Overview
    MyGene.info: GBP5
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:142496934-142522344 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 66.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    225 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2429943
protein coding gene Chr3:142493978-142522344 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027941
protein coding gene Chr3:145662510-145704219 (+)
A/J MGP_AJ_G0027898
protein coding gene Chr3:140508289-140550491 (+)
AKR/J MGP_AKRJ_G0027864
protein coding gene Chr3:144234746-144259592 (+)
BALB/cJ MGP_BALBcJ_G0027910
protein coding gene Chr3:140315178-140354743 (+)
C3H/HeJ MGP_C3HHeJ_G0027640
protein coding gene Chr3:144566911-144611475 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028354
protein coding gene Chr3:150743920-150778033 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025692
protein coding gene Chr3:135765885-135787581 (+)
CAST/EiJ MGP_CASTEiJ_G0027098
protein coding gene Chr3:144583733-144593238 (-)
CBA/J MGP_CBAJ_G0027617
protein coding gene Chr3:155941764-155968041 (+)
DBA/2J MGP_DBA2J_G0027756
protein coding gene Chr3:139658810-139681242 (+)
FVB/NJ MGP_FVBNJ_G0027723
protein coding gene Chr3:137080661-137102325 (+)
LP/J MGP_LPJ_G0027866
protein coding gene Chr3:147101146-147137895 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027755
protein coding gene Chr3:164259052-164286544 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028412
protein coding gene Chr3:143845758-143874726 (+)
PWK/PhJ MGP_PWKPhJ_G0026820
protein coding gene Chr3:139462379-139493785 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026647
protein coding gene Chr3:141967553-141998716 (+)
WSB/EiJ MGP_WSBEiJ_G0027175
protein coding gene Chr3:144708985-144735126 (+)



Homology
more
  • Human Ortholog
    GBP5, guanylate binding protein 5
  • Vertebrate Orthologs
    6
  • Human Ortholog
    GBP5, guanylate binding protein 5
    Orthology source: HomoloGene
  • Synonyms
    GBP-5
  • Links
    NCBI Gene ID: 115362
    neXtProt AC: NX_Q96PP8
    UniProt: Q96PP8

  • Chr Location
    1p22.2; chr1:89258950-89272861 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to Listeria infection and NLRP3 inflammation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 229898 NCBI Gene Model | MGI Sequence Detail 25411 C57BL/6J ±  kb
transcript NM_153564 RefSeq | MGI Sequence Detail 3021 C57BL/6  
polypeptide Q8CFB4 UniProt | EBI | MGI Sequence Detail 590 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • EC
  • InterPro Domains
    IPR030386 GB1/RHD3-type guanine nucleotide-binding (G) domain
    IPR003191 Guanylate-binding protein/Atlastin, C-terminal
    IPR037684 Guanylate-binding protein, C-terminal
    IPR036543 Guanylate-binding protein, C-terminal domain superfamily
    IPR015894 Guanylate-binding protein, N-terminal
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 18
    cDNA 18

    Microarray probesets 1
Other
Accession IDs
less
MGI:2444553
References
more
  • Summaries
    All 38
    Diseases 1
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:258482 Santos JC, et al., LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation. EMBO J. 2018 Mar 15;37(6)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory