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Ifnlr1
Gene Detail
Symbol

Name
ID
Ifnlr1
interferon lambda receptor 1
MGI:2429859
Synonyms
CRF2-12, IFNLR1, Il28ra
Feature Type
protein coding gene
Genetic Map
Chromosome 4
67.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:135686287-135708181 bp, + strand
From VEGA annotation of GRCm38

  21895 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:52086  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: IFNLR1
Gene Tree: Ifnlr1

Human
homologs
IFNLR1, interferon, lambda receptor 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 163702
neXtProt AC: NX_Q8IU57

Human Synonyms: CRF2/12, IFNLR, IL-28R1, IL28RA, LICR2

Human Chr (Location): 1p36.11; chr1:24154157-24187275 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Genomic Mutations involving Ifnlr1 (1)
Incidental mutations (data from APF , CvDC )
 
Homozygous null mice are viable and normal with respect to viral infection, however antiviral response evoked by TLRs are significantly reduced.
 
Interactions
Ifnlr1 interacts with 293 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cytokine-mediated signaling pathway, defense response to virus, ...
Component integral component of membrane, interleukin-28 receptor complex, ...
Function cytokine receptor activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (81)    Tissues (12)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 81
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ifnlr1    NEW 
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000009736 (Evidence)
Ensembl Gene Model ENSMUSG00000062157 (Evidence)
Entrez Gene 242700 (Evidence)
UniGene 259623
DFCI TC1585685
DoTS DT.101165580, DT.482317
NIA Mouse Gene Index U067615
Consensus CDS Project CCDS18788.1
International Mouse Phenotyping Consortium Status Ifnlr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009736 VEGA Gene Model | MGI Sequence Detail 21895 C57BL/6J ±  kb
transcript OTTMUST00000022482 VEGA | MGI Sequence Detail 4182 Not Applicable 
polypeptide OTTMUSP00000010256 VEGA | MGI Sequence Detail 535 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(142 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin type III
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000009003 interleukin-28 receptor alpha chain
References
(Earliest) J:81434 Kotenko SV, et al., IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol. 2003 Jan;4(1):69-77
(Latest) J:222597 Anggakusuma, et al., Control of hepatitis C virus replication in mouse liver-derived cells by MAVS-dependent production of type I and type III interferons. J Virol. 2015 Apr;89(7):3833-45
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory