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Ifnlr1
Gene Detail
Symbol

Name
ID
Ifnlr1
interferon lambda receptor 1
MGI:2429859
Synonyms
CRF2-12, IFNLR1, Il28ra
Feature Type
protein coding gene
Genetic Map
Chromosome 4
67.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:135686287-135708181 bp, + strand
From VEGA annotation of GRCm38

  21895 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:52086  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Ifnlr1

Human
homologs
Human Homolog IFNLR1, interferon, lambda receptor 1
NCBI Gene ID 163702
neXtProt AC  NX_Q8IU57
Human Synonyms  CRF2/12, IFNLR, IL-28R1, IL28RA, LICR2
Human Chr (Location)  1p36.11; chr1:24154157-24187275 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from APF )
 
Homozygous null mice are viable and normal with respect to viral infection, however antiviral response evoked by TLRs are significantly reduced.
 
Interactions
Ifnlr1 interacts with 294 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cytokine-mediated signaling pathway, defense response to virus, ...
Component integral component of membrane, interleukin-28 receptor complex, ...
Function cytokine receptor activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (81)    Tissues (12)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 81
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000009736 (Evidence)
Ensembl Gene ModelENSMUSG00000062157 (Evidence)
Entrez Gene242700 (Evidence)
UniGene259623
DFCITC1585685
DoTSDT.101165580, DT.482317
NIA Mouse Gene IndexU067615
Consensus CDS ProjectCCDS18788.1
International Mouse Knockout Project StatusIfnlr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009736 VEGA Gene Model | MGI Sequence Detail 21895 C57BL/6J ±  kb
transcript OTTMUST00000022482 VEGA | MGI Sequence Detail 4182 Not Applicable 
polypeptide OTTMUSP00000010256 VEGA | MGI Sequence Detail 535 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(142 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000009003 interleukin-28 receptor alpha chain
References
(Earliest) J:81434 Kotenko SV, et al., IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol. 2003 Jan;4(1):69-77
(Latest) J:212777 Hermant P, et al., Human but not mouse hepatocytes respond to interferon-lambda in vivo. PLoS One. 2014;9(1):e87906
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory