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Nle1 Gene Detail
Summary
  • Symbol
    Nle1
  • Name
    notchless homolog 1
  • Synonyms
    l11Jus1, l11Jus4, MGC:25690, Nle, notchless
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429770
    NCBI Gene: 217011
  • Gene Overview
    MyGene.info: NLE1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:82900768-82908411 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 50.30 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    100 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2429770
protein coding gene Chr11:82900768-82908445 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018834
protein coding gene Chr11:84189821-84197542 (-)
A/J MGP_AJ_G0018801
protein coding gene Chr11:80950238-80958051 (-)
AKR/J MGP_AKRJ_G0018771
protein coding gene Chr11:83381070-83388712 (-)
BALB/cJ MGP_BALBcJ_G0018774
protein coding gene Chr11:81353961-81361597 (-)
C3H/HeJ MGP_C3HHeJ_G0018588
protein coding gene Chr11:83411241-83418954 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019226
protein coding gene Chr11:86707927-86715570 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016860
protein coding gene Chr11:77913484-77921460 (-)
CAST/EiJ MGP_CASTEiJ_G0018143
protein coding gene Chr11:84000734-84009326 (-)
CBA/J MGP_CBAJ_G0018559
protein coding gene Chr11:90461617-90469338 (-)
DBA/2J MGP_DBA2J_G0018667
protein coding gene Chr11:80524894-80532577 (-)
FVB/NJ MGP_FVBNJ_G0018656
protein coding gene Chr11:80050318-80057963 (-)
LP/J MGP_LPJ_G0018737
protein coding gene Chr11:84699518-84707229 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018683
protein coding gene Chr11:90658084-90665729 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019266
protein coding gene Chr11:83640149-83647791 (-)
PWK/PhJ MGP_PWKPhJ_G0017913
protein coding gene Chr11:81346510-81354839 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017704
protein coding gene Chr11:83262014-83270390 (-)
WSB/EiJ MGP_WSBEiJ_G0018195
protein coding gene Chr11:83526740-83534378 (-)



Homology
more
  • Human Ortholog
    NLE1, notchless homolog 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NLE1, notchless homolog 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NLE
  • Links
    NCBI Gene ID: 54475
    neXtProt AC: NX_Q9NVX2
    UniProt: Q9NVX2

  • Chr Location
    17q12; chr17:35128755-35142315 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5494
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NLE1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 6 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality before somite formation, most blastocysts fail to hatch out of the zona pellucida, and apoptosis is increased in the inner cell mass.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020692 Ensembl Gene Model | MGI Sequence Detail 7644 C57BL/6J ±  kb
    transcript ENSMUST00000103213 Ensembl | MGI Sequence Detail 1783 Not Applicable  
    polypeptide ENSMUSP00000099502 Ensembl | MGI Sequence Detail 485 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 30
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144343, MGI:2385862, MGI:2671264, MGI:2671268
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:258554 Stedman A, et al., Ribosome biogenesis dysfunction leads to p53-mediated apoptosis and goblet cell differentiation of mouse intestinal stem/progenitor cells. Cell Death Differ. 2015 Nov;22(11):1865-76

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory