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Trpv5 Gene Detail
Summary
  • Symbol
    Trpv5
  • Name
    transient receptor potential cation channel, subfamily V, member 5
  • Synonyms
    CaT2, ECaC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429764
    NCBI Gene: 194352
  • Gene Overview
    MyGene.info: TRPV5
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:41652173-41680769 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 19.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    126 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2429764
protein coding gene Chr6:41651661-41681453 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030632
protein coding gene Chr6:40169147-40197753 (-)
A/J MGP_AJ_G0030605
protein coding gene Chr6:38421484-38450047 (-)
AKR/J MGP_AKRJ_G0030530
protein coding gene Chr6:39666295-39694856 (-)
BALB/cJ MGP_BALBcJ_G0030615
protein coding gene Chr6:38626621-38655466 (-)
C3H/HeJ MGP_C3HHeJ_G0030328
protein coding gene Chr6:39689334-39718412 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031069
protein coding gene Chr6:41189359-41218859 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028276
protein coding gene Chr6:36194410-36224094 (-)
CAST/EiJ MGP_CASTEiJ_G0029732
protein coding gene Chr6:39496030-39550412 (-)
CBA/J MGP_CBAJ_G0030304
protein coding gene Chr6:42889496-42918077 (-)
DBA/2J MGP_DBA2J_G0030448
protein coding gene Chr6:38250195-38278657 (-)
FVB/NJ MGP_FVBNJ_G0030404
protein coding gene Chr6:37971726-38000699 (-)
LP/J MGP_LPJ_G0030536
protein coding gene Chr6:40170673-40200200 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030438
protein coding gene Chr6:45121209-45150388 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031099
protein coding gene Chr6:39636792-39689375 (-)
PWK/PhJ MGP_PWKPhJ_G0029444
protein coding gene Chr6:37871471-37923332 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029281
protein coding gene Chr6:39251277-39280875 (-)
WSB/EiJ MGP_WSBEiJ_G0029808
protein coding gene Chr6:39549481-39602106 (-)



Homology
more
  • Human Ortholog
    TRPV5, transient receptor potential cation channel subfamily V member 5
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TRPV5, transient receptor potential cation channel subfamily V member 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAT2, ECAC1, OTRPC3
  • Links
    NCBI Gene ID: 56302
    neXtProt AC: NX_Q9NQA5
    UniProt: Q9NQA5

  • Chr Location
    7q34; chr7:142908101-142933723 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit increased calcium excretion and reduced bone thickenss.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036899 Ensembl Gene Model | MGI Sequence Detail 28597 C57BL/6J ±  kb
    transcript ENSMUST00000031901 Ensembl | MGI Sequence Detail 3243 Not Applicable  
    polypeptide ENSMUSP00000031901 Ensembl | MGI Sequence Detail 723 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000000776 transient receptor potential cation channel subfamily V member 5
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR020683 Ankyrin repeat-containing domain
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR005821 Ion transport domain
      IPR024862 Transient receptor potential cation channel subfamily V
      IPR008346 Transient receptor potential cation channel subfamily V member 5
      IPR008344 Transient receptor potential cation channel subfamily V member 5/6
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 6
      Primer pair 2

      Microarray probesets 1
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 6
      Gene Ontology 12
      Phenotypes 13
    • Earliest
      J:78617 Nilius B, et al., Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3. J Biol Chem. 2002 Aug 23;277(34):30852-8
    • Latest
      J:243840 Gerl K, et al., Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development. Am J Pathol. 2017 Jul;187(7):1496-1511

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory