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Dock3 Gene Detail
Summary
  • Symbol
    Dock3
  • Name
    dedicator of cyto-kinesis 3
  • Synonyms
    Moca, PBP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429763
    NCBI Gene: 208869
  • Gene Overview
    MyGene.info: DOCK3
Location & Maps
more
  • Sequence Map
    Chr9:106892825-107231909 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      339085 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 57.98 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    DOCK3, dedicator of cytokinesis 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DOCK3, dedicator of cytokinesis 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MOCA, PBP
  • Links
    NCBI Gene ID: 1795
    neXtProt AC: NX_Q8IZD9

  • Chr Location
    3p21.2; chr3:50674969-51384198 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 21030
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DOCK3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal behaviors and muscular weakness associated with axonal dystrophy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036142 VEGA Gene Model | MGI Sequence Detail 339085 C57BL/6J ±  kb
transcript OTTMUST00000092917 VEGA | MGI Sequence Detail 9063 Not Applicable  
polypeptide OTTMUSP00000051453 VEGA | MGI Sequence Detail 2030 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1851 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 43
    Genomic 1
    cDNA 41
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:79164 Kashiwa A, et al., Isolation and characterization of novel presenilin binding protein. J Neurochem. 2000 Jul;75(1):109-16
  • Latest
    J:215373 Semba K, et al., Dock3 overexpression and p38 MAPK inhibition synergistically stimulate neuroprotection and axon regeneration after optic nerve injury. Neurosci Lett. 2014 Oct 3;581:89-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory