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Dock3 Gene Detail
Summary
  • Symbol
    Dock3
  • Name
    dedicator of cyto-kinesis 3
  • Synonyms
    Moca, PBP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429763
    NCBI Gene: 208869
  • Gene Overview
    MyGene.info: DOCK3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:106892825-107231909 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 57.98 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1851 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2429763
protein coding gene Chr9:106892825-107231909 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035247
protein coding gene Chr9:108743079-109086995 (-)
A/J MGP_AJ_G0035226
protein coding gene Chr9:104794130-105124698 (-)
AKR/J MGP_AKRJ_G0035158
protein coding gene Chr9:107396476-107742561 (-)
BALB/cJ MGP_BALBcJ_G0035220
protein coding gene Chr9:104474582-104795101 (-)
C3H/HeJ MGP_C3HHeJ_G0034930
protein coding gene Chr9:107813651-108144710 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035740
protein coding gene Chr9:111723752-112083342 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032638
protein coding gene Chr9:102269973-102556491 (-)
CAST/EiJ MGP_CASTEiJ_G0034241
protein coding gene Chr9:107740848-108072679 (-)
CBA/J MGP_CBAJ_G0034898
protein coding gene Chr9:115701111-116060545 (-)
DBA/2J MGP_DBA2J_G0035059
protein coding gene Chr9:104248998-104579246 (-)
FVB/NJ MGP_FVBNJ_G0035007
protein coding gene Chr9:103032363-103337761 (-)
LP/J MGP_LPJ_G0035135
protein coding gene Chr9:108948485-109293623 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035046
protein coding gene Chr9:117255670-117646270 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035761
protein coding gene Chr9:107676138-108010939 (-)
PWK/PhJ MGP_PWKPhJ_G0033948
protein coding gene Chr9:104564782-104891524 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033783
protein coding gene Chr9:107746072-108071341 (-)
WSB/EiJ MGP_WSBEiJ_G0034362
protein coding gene Chr9:107574329-107897672 (-)



Homology
more
  • Human Ortholog
    DOCK3, dedicator of cytokinesis 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DOCK3, dedicator of cytokinesis 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MOCA, PBP
  • Links
    NCBI Gene ID: 1795
    neXtProt AC: NX_Q8IZD9
    UniProt: Q8IZD9

  • Chr Location
    3p21.2; chr3:50674969-51384198 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 21030
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DOCK3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal behaviors and muscular weakness associated with axonal dystrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 208869 NCBI Gene Model | MGI Sequence Detail 339085 C57BL/6J ±  kb
    transcript NM_153413 RefSeq | MGI Sequence Detail 9067 C57BL/6  
    polypeptide Q8CIQ7 UniProt | EBI | MGI Sequence Detail 2027 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 2
      cDNA 41
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 5
    • Earliest
      J:79164 Kashiwa A, et al., Isolation and characterization of novel presenilin binding protein. J Neurochem. 2000 Jul;75(1):109-16
    • Latest
      J:215373 Semba K, et al., Dock3 overexpression and p38 MAPK inhibition synergistically stimulate neuroprotection and axon regeneration after optic nerve injury. Neurosci Lett. 2014 Oct 3;581:89-93

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory