About   Help   FAQ
Tbc1d4
Gene Detail
 Symbol
Name
ID
Tbc1d4
TBC1 domain family, member 4
MGI:2429660
Synonyms 5930406J04Rik, AS160
Feature Type protein coding gene
Genetic Map
Chromosome 14
50.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:101442360-101609191 bp, - strand
From VEGA annotation of GRCm38

  166832 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:45451  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tbc1d4

Human
homologs
Human Homolog TBC1D4, TBC1 domain family, member 4
NCBI Gene ID 9882
neXtProt AC  NX_O60343
Human Synonyms  AS160
Human Chr (Location)  13q22.2; chr13:75284664-75482646 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in allele show abnormal glucose homeostasis and increased testis and heart weight. Mice homozygous for a knock-out allele exhibit increased parametrial and epididymal fat pad weight and abnormal glucose homeostasis.
 
Interactions
Tbc1d4 interacts with 343 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cellular response to insulin stimulus, negative regulation of vesicle fusion, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function GTPase activator activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (12)    Tissues (12)   
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
Northern blot 12
cDNA source data(53)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) cDNA(54) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000034685 (Evidence)
Ensembl Gene ModelENSMUSG00000033083 (Evidence)
Entrez Gene210789 (Evidence)
UniGene320639
DFCITC1582079, TC1602342, TC1620529, TC1625980, TC1633549
DoTSDT.101704140, DT.40175337, DT.60103482, DT.91561023, DT.97344450, DT.97392158
NIA Mouse Gene IndexU035868
Consensus CDS ProjectCCDS49556.1
International Mouse Knockout Project StatusTbc1d4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034685 VEGA Gene Model | MGI Sequence Detail 166832 C57BL/6J ±  kb
transcript OTTMUST00000088057 VEGA | MGI Sequence Detail 4762 Not Applicable 
polypeptide OTTMUSP00000047972 VEGA | MGI Sequence Detail 1306 Not Applicable 

For the selected sequences
All sequences(93) RefSeq(23) UniProt(7)
Polymorphisms SNPs within 2kb(407 from dbSNP Build 137)    SNPs within 2kb including multiple locations(415)
Protein-related
information
ResourceIDDescription
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR021785 Protein of unknown function DUF3350
InterPro IPR000195 Rab-GTPase-TBC domain
Protein Ontology PR:000016118 TBC1 domain family member 4
References (Earliest) J:74603 Kurihara LJ, et al., Candidate genes required for embryonic development: a comparative analysis of distal mouse chromosome 14 and human chromosome 13q22. Genomics. 2002 Feb;79(2):154-61
(Latest) J:194026 Wang HY, et al., AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues. Biochem J. 2013 Jan 15;449(2):479-89
All references(45)
Other
accession IDs
MGI:2442592, MGI:3034398

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory