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Tbc1d4
Gene Detail
Symbol

Name
ID
Tbc1d4
TBC1 domain family, member 4
MGI:2429660
Synonyms
5930406J04Rik, AS160
Feature Type
protein coding gene
Genetic Map
Chromosome 14
50.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:101442360-101609191 bp, - strand
From VEGA annotation of GRCm38

  166832 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:45451  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TBC1D4
Gene Tree: Tbc1d4

Human
homologs
TBC1D4, TBC1 domain family, member 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9882
neXtProt AC: NX_O60343

Human Synonyms: AS160, NIDDM5

Human Chr (Location): 13q22.2; chr13:75284664-75482646 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TBC1D4

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Tbc1d4 interacts with 342 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cellular response to insulin stimulus, negative regulation of vesicle fusion, ...
Component cytoplasm, extracellular exosome, ...
Function GTPase activator activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (12)    Tissues (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 12
cDNA source data(53)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tbc1d4 ; ZFIN si:ch211-222g23.4    NEW 
Molecular
reagents
All nucleic(55) cDNA(54) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000034685 (Evidence)
Ensembl Gene Model ENSMUSG00000033083 (Evidence)
Entrez Gene 210789 (Evidence)
UniGene 320639
DFCI TC1633549, TC1602342, TC1620529, TC1625980, TC1582079
DoTS DT.40175337, DT.101704140, DT.60103482, DT.97392158, DT.97344450, DT.91561023
NIA Mouse Gene Index U035868
Consensus CDS Project CCDS49556.1
International Mouse Phenotyping Consortium Status Tbc1d4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034685 VEGA Gene Model | MGI Sequence Detail 166832 C57BL/6J ±  kb
transcript OTTMUST00000088057 VEGA | MGI Sequence Detail 4762 Not Applicable 
polypeptide OTTMUSP00000047972 VEGA | MGI Sequence Detail 1306 Not Applicable 

For the selected sequences
All sequences(96) RefSeq(25) UniProt(7)
Polymorphisms
SNPs within 2kb(407 from dbSNP Build 137)    SNPs within 2kb including multiple locations(415)
Protein-related
information
ResourceIDDescription
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR021785 Protein of unknown function DUF3350
InterPro IPR000195 Rab-GTPase-TBC domain
Protein Ontology PR:000016118 TBC1 domain family member 4
References
(Earliest) J:74603 Kurihara LJ, et al., Candidate genes required for embryonic development: a comparative analysis of distal mouse chromosome 14 and human chromosome 13q22. Genomics. 2002 Feb;79(2):154-61
(Latest) J:194026 Wang HY, et al., AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues. Biochem J. 2013 Jan 15;449(2):479-89
All references(43)
Other
accession IDs
MGI:2442592, MGI:3034398

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory