About   Help   FAQ
Irak2
Gene Detail
Symbol

Name
ID
Irak2
interleukin-1 receptor-associated kinase 2
MGI:2429603
Synonyms
6330415L08Rik, IRAK-2, Irak2a, Irak2b, Irak2c, Irak2d
Feature Type
protein coding gene
Genetic Map
Chromosome 6
52.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:113638467-113695009 bp, + strand
From VEGA annotation of GRCm38

  56543 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1207  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: IRAK2
Protein SuperFamily: interleukin-1 receptor associated kinase, IRAK-1/IRAK-2 types
Gene Tree: Irak2

Human
homologs
IRAK2, interleukin-1 receptor-associated kinase 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3656
neXtProt AC: NX_O43187

Human Synonyms: IRAK-2

Human Chr (Location): 3p25.3; chr3:10164879-10243745 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(37) : Gene trapped(29) Spontaneous(1) Targeted(7)
Genomic Mutations involving Irak2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit decreased susceptibility to endotoxin shock.
 
Interactions
Irak2 interacts with 192 markers (Mir1b, Mir7-1, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process interleukin-1-mediated signaling pathway, intracellular signal transduction, ...
Component cytoplasm, nucleus, ...
Function ATP binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (19)    Tissues (2)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 19
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase irak2    NEW 
Molecular
reagents
All nucleic(24) cDNA(24)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000023746 (Evidence)
Ensembl Gene Model ENSMUSG00000060477 (Evidence)
Entrez Gene 108960 (Evidence)
UniGene 152142
DFCI TC1579534, TC1594891, TC1596704, TC1598217
DoTS DT.101304655, DT.102534054, DT.55122976, DT.60118139
NIA Mouse Gene Index U007280
Consensus CDS Project CCDS20430.1, CCDS51873.1
International Mouse Phenotyping Consortium Status Irak2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023746 VEGA Gene Model | MGI Sequence Detail 56543 C57BL/6J ±  kb
transcript OTTMUST00000058006 VEGA | MGI Sequence Detail 3179 Not Applicable 
polypeptide OTTMUSP00000028052 VEGA | MGI Sequence Detail 622 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(478 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000001783 interleukin-1 receptor-associated kinase-like 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205798 Pauls E, et al., Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice. J Immunol. 2013 Sep 1;191(5):2717-30
All references(48)
Other
accession IDs
MGI:1922037, MGI:2141461

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory