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Irak2 Gene Detail
Summary
  • Symbol
    Irak2
  • Name
    interleukin-1 receptor-associated kinase 2
  • Synonyms
    6330415L08Rik, IRAK-2, Irak2a, Irak2b, Irak2c, Irak2d
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429603
    NCBI Gene: 108960
  • Gene Overview
    MyGene.info: IRAK2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:113638467-113695026 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      56560 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 52.82 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    IRAK2, interleukin 1 receptor associated kinase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IRAK2, interleukin 1 receptor associated kinase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IRAK-2
  • Links
    NCBI Gene ID: 3656
    neXtProt AC: NX_O43187
    UniProt: O43187

  • Chr Location
    3p25.3; chr3:10164879-10243743 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased susceptibility to endotoxin shock.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023746 VEGA Gene Model | MGI Sequence Detail 56560 C57BL/6J ±  kb
    transcript OTTMUST00000058006 VEGA | MGI Sequence Detail 3196 Not Applicable  
    polypeptide OTTMUSP00000028052 VEGA | MGI Sequence Detail 622 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      479 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 25

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1922037, MGI:2141461
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:247609 Zhou H, et al., IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs. Elife. 2017 Oct 09;6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory