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Pdzd3 Gene Detail
Summary
  • Symbol
    Pdzd3
  • Name
    PDZ domain containing 3
  • Synonyms
    NaPi-Cap2, Pdzk2, sodium-phosphate cotransporter IIa C-terminal-associated protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429554
    NCBI Gene: 170761
Location & Maps
more
  • Sequence Map
    Chr9:44247312-44251464 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4153 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PDZD3, PDZ domain containing 3
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PDZD3, PDZ domain containing 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IKEPP, NHERF4, PDZK2
  • Links
    NCBI Gene ID: 79849
    neXtProt AC: NX_Q86UT5

  • Chr Location
    11q23.3; chr11:119185436-119190223 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 11719
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: PDZD3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Gene trapped
    1
  • Targeted
    4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 170761 NCBI Gene Model | MGI Sequence Detail 4153 C57BL/6J ±  kb
transcript NM_133226 RefSeq | MGI Sequence Detail 2181 C57BL/6  
polypeptide Q99MJ6 UniProt | EBI | MGI Sequence Detail 498 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    63 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR031200 Na(+)/H(+) exchange regulatory cofactor NHERF-4
    IPR001478 PDZ domain
Molecular
Reagents
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  • All nucleic 22
    cDNA 21
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:74952 Gisler SM, et al., Interaction of the type IIa Na/Pi cotransporter with PDZ proteins. J Biol Chem. 2001 Mar 23;276(12):9206-13
  • Latest
    J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory