About   Help   FAQ
Due to maintenance, access to MGI may be intermittent 8:00 AM ET Wed, September 18.
Adam1a Gene Detail
Summary
  • Symbol
    Adam1a
  • Name
    a disintegrin and metallopeptidase domain 1a
  • Synonyms
    fertilin alpha, Ftna, PH-30 alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429504
    NCBI Gene: 280668
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:121518604-121521695 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 61.84 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    21 from dbSNP Build 142
  • Strain Annotations
    15
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2429504
protein coding gene Chr5:121518576-121545482 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030030
protein coding gene Chr5:125010859-125014348 (-)
A/J MGP_AJ_G0029995
protein coding gene Chr5:119861623-119865494 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0030006
protein coding gene Chr5:121244579-121250541 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0030459
protein coding gene Chr5:129768101-129771825 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027685
protein coding gene Chr5:114536742-114540234 (-)
CAST/EiJ MGP_CASTEiJ_G0029132
protein coding gene Chr5:123416024-123418581 (-)
CBA/J MGP_CBAJ_G0029693
protein coding gene Chr5:134872841-134877934 (-)
DBA/2J MGP_DBA2J_G0029843
protein coding gene Chr5:119932022-119934617 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0029932
protein coding gene Chr5:125524812-125527803 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029830
protein coding gene Chr5:138723526-138728343 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030500
protein coding gene Chr5:123259610-123264092 (-)
PWK/PhJ MGP_PWKPhJ_G0028846
protein coding gene Chr5:118707491-118712074 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028683
protein coding gene Chr5:121016959-121022353 (-)
WSB/EiJ MGP_WSBEiJ_G0029207
protein coding gene Chr5:123913406-123918403 (-)



Homology
more
  • Human Ortholog
    ADAM1A, ADAM metallopeptidase domain 1A (pseudogene)
  • Vertebrate Orthologs
    5
  • Human Ortholog
    ADAM1A, ADAM metallopeptidase domain 1A (pseudogene)
    Orthology source: HGNC
  • Synonyms
    ADAM1, ADAM1P, Ftna, FTNAP, PH-30a
  • Links
    NCBI Gene ID: 8759

  • Chr Location
    12q24.12-q24.13; chr12:111899063-111901902 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Adam1a
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Homozygous null mice display male infertility with asthenozoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 280668 NCBI Gene Model | MGI Sequence Detail 3092 C57BL/6J ±  kb
transcript NM_172126 RefSeq | MGI Sequence Detail 3114 C57BL/6  
polypeptide Q60813 UniProt | EBI | MGI Sequence Detail 791 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 3
    cDNA 18

    Microarray probesets 4
References
more
  • Summaries
    All 35
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/05/2019
MGI 6.14
The Jackson Laboratory