About   Help   FAQ
Gprc6a
Gene Detail
Symbol

Name
ID
Gprc6a
G protein-coupled receptor, family C, group 6, member A
MGI:2429498
Feature Type
protein coding gene
Genetic Map
Chromosome 10
25.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:51614823-51631458 bp, - strand
From Ensembl annotation of GRCm38

  16636 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17529  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GPRC6A
Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Gprc6a

Human
homologs
GPRC6A, G protein-coupled receptor, class C, group 6, member A
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 222545
neXtProt AC: NX_Q5T6X5

Human Synonyms: bA86F4.3, GPCR

Human Chr (Location): 6q22.1; chr6:116792085-116829057 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele show a metabolic syndrome characterized by impaired bone mineralization, increased fat mass, abnormal renal handling of calcium and phosphorus, fatty liver, glucose intolerance, testicular feminization and abnormal steroidogenesis.
 
Interactions
Gprc6a interacts with 34 markers (Mir1b, Mir34a, Mir34b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
cDNA source data(1)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gprc6a    NEW 
Molecular
reagents
All nucleic(1) cDNA(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000019905 (Evidence)
Entrez Gene 210198 (Evidence)
UniGene 221031
DFCI TC1594796
DoTS DT.101349980, DT.110592676, DT.110592678
Consensus CDS Project CCDS23834.1
International Mouse Phenotyping Consortium Status Gprc6a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019905 Ensembl Gene Model | MGI Sequence Detail 16636 C57BL/6J ±  kb
transcript ENSMUST00000020062 Ensembl | MGI Sequence Detail 2856 Not Applicable 
polypeptide ENSMUSP00000020062 Ensembl | MGI Sequence Detail 928 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(209 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000337 GPCR, family 3
InterPro IPR017979 GPCR, family 3, conserved site
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR011500 GPCR, family 3, nine cysteines domain
Protein Ontology PR:000008198 G-protein coupled receptor family C group 6 member A
References
(Earliest) J:104103 Pi M, et al., Identification of a novel extracellular cation-sensing G-protein-coupled receptor. J Biol Chem. 2005 Dec 2;280(48):40201-9
(Latest) J:208919 Wei J, et al., Osteocalcin promotes beta-cell proliferation during development and adulthood through Gprc6a. Diabetes. 2014 Mar;63(3):1021-31
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory