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Gprc6a
Gene Detail
 Symbol
Name
ID
Gprc6a
G protein-coupled receptor, family C, group 6, member A
MGI:2429498
Feature Type protein coding gene
Genetic Map
Chromosome 10
25.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:51614823-51631458 bp, - strand
From NCBI annotation of GRCm38

  16636 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17529  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Gprc6a

Human
homologs
Human Homolog GPRC6A, G protein-coupled receptor, class C, group 6, member A
NCBI Gene ID 222545
neXtProt AC  NX_Q5T6X5
Human Synonyms  bA86F4.3, GPCR
Human Chr (Location)  6q22.1; chr6:116792085-116829057 (-)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show a metabolic syndrome characterized by impaired bone mineralization, increased fat mass, abnormal renal handling of calcium and phosphorus, fatty liver, glucose intolerance, testicular feminization and abnormal steroidogenesis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process calcium-mediated signaling, G-protein coupled receptor signaling pathway, ...
Component cell surface, integral component of membrane, ...
Function G-protein coupled receptor activity, signal transducer activity
External Resources: FuncBase
Expression
cDNA source data(1)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(1) cDNA(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000019905 (Evidence)
Entrez Gene210198 (Evidence)
UniGene221031
DFCITC1594796
DoTSDT.101349980, DT.110592676, DT.110592678
Consensus CDS ProjectCCDS23834.1
International Mouse Knockout Project StatusGprc6a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 210198 NCBI Gene Model | MGI Sequence Detail 16636 C57BL/6J ±  kb
transcript NM_153071 RefSeq | MGI Sequence Detail 2856 NIH Swiss 
polypeptide Q8K4Z6 UniProt | EBI | MGI Sequence Detail 928 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(209 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000337 GPCR, family 3
InterPro IPR017979 GPCR, family 3, conserved site
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR011500 GPCR, family 3, nine cysteines domain
Protein Ontology PR:000008198 G-protein coupled receptor family C group 6 member A
Graphical View of Protein Domain Structure
References (Earliest) J:104103 Pi M, et al., Identification of a novel extracellular cation-sensing G-protein-coupled receptor. J Biol Chem. 2005 Dec 2;280(48):40201-9
(Latest) J:208919 Wei J, et al., Osteocalcin promotes beta-cell proliferation during development and adulthood through Gprc6a. Diabetes. 2014 Mar;63(3):1021-31
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory