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Gprc6a Gene Detail
Summary
  • Symbol
    Gprc6a
  • Name
    G protein-coupled receptor, family C, group 6, member A
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429498
    NCBI Gene: 210198
Location & Maps
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  • Sequence Map
    Chr10:51614823-51631458 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16636 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    GPRC6A, G protein-coupled receptor, class C, group 6, member A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GPRC6A, G protein-coupled receptor, class C, group 6, member A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bA86F4.3, GPCR
  • Links
    NCBI Gene ID: 222545
    neXtProt AC: NX_Q5T6X5

  • Chr Location
    6q22.1; chr6:116792085-116829057 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Gprc6a
  • Incidental Mutations
Mice homozygous for a knock-out allele show a metabolic syndrome characterized by impaired bone mineralization, increased fat mass, abnormal renal handling of calcium and phosphorus, fatty liver, glucose intolerance, testicular feminization and abnormal steroidogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019905 Ensembl Gene Model | MGI Sequence Detail 16636 C57BL/6J ±  kb
transcript ENSMUST00000020062 Ensembl | MGI Sequence Detail 2856 Not Applicable  
polypeptide ENSMUSP00000020062 Ensembl | MGI Sequence Detail 928 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    209 from dbSNP Build 137
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008198 G-protein coupled receptor family C group 6 member A
  • InterPro Domains
    IPR000337 GPCR, family 3
    IPR017979 GPCR, family 3, conserved site
    IPR017978 GPCR family 3, C-terminal
    IPR011500 GPCR, family 3, nine cysteines domain
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
Molecular
Reagents
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  • All nucleic 1
    cDNA 1

    Microarray probesets 2
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:104103 Pi M, et al., Identification of a novel extracellular cation-sensing G-protein-coupled receptor. J Biol Chem. 2005 Dec 2;280(48):40201-9
  • Latest
    J:208919 Wei J, et al., Osteocalcin promotes beta-cell proliferation during development and adulthood through Gprc6a. Diabetes. 2014 Mar;63(3):1021-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory