Afm
Gene Detail

Symbol Name ID

Afm afamin MGI:2429409

Synonyms

Alf, alpha albumin

Feature Type

protein coding gene

Genetic Map

Chromosome 5

44.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr5:90518932-90553543 bp, + strand From VEGA annotation of GRCm38   34612 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:881  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: serum albumin
Gene Tree: Afm

Human homologs

Human Homolog		AFM, afamin
NCBI Gene ID		173
neXtProt AC		NX_P43652
Human Synonyms		ALB2, ALBA, ALF
Human Chr (Location)		4q13.3; chr4:74347462-74369718 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	transport, vitamin transport
Component	extracellular region, extracellular space
Function	vitamin E binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (50)    Tissues (7)    Images (19)
Theiler Stages: 23, 26, 28

Assay Type	Results
RNA in situ	46
RT-PCR	4

cDNA source data(58)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(59) cDNA(58) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000033292 (Evidence)
Ensembl Gene Model	ENSMUSG00000029369 (Evidence)
Entrez Gene	280662 (Evidence)
UniGene	348786
DFCI	TC1579673, TC1674123
DoTS	DT.534669, DT.94370808
NIA Mouse Gene Index	U005778
Consensus CDS Project	CCDS39141.1
International Mouse Knockout Project Status	Afm

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033292	VEGA Gene Model | MGI Sequence Detail	34612	C57BL/6J
transcript	OTTMUST00000083498	VEGA | MGI Sequence Detail	2038	Not Applicable
polypeptide	OTTMUSP00000044892	VEGA | MGI Sequence Detail	608	Not Applicable

All sequences(25) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(107 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001703	Alpha-fetoprotein
InterPro	IPR000264	Serum albumin
InterPro	IPR020857	Serum albumin, conserved site
InterPro	IPR020858	Serum albumin-like
InterPro	IPR014760	Serum albumin, N-terminal
InterPro	IPR021177	Serum albumin, subgroup
Protein Ontology	PR:000003808	afamin

References

(Earliest) J:79500 Gabant P, et al., Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12865-70
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(31)