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Adamtsl4
Gene Detail
Symbol

Name
ID
Adamtsl4
ADAMTS-like 4
MGI:2389008
Synonyms
Tsrc1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
40.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:95676201-95687917 bp, - strand
From VEGA annotation of GRCm38

  11717 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23141  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADAMTSL4
Gene Tree: Adamtsl4

Human
homologs
ADAMTSL4, ADAMTS-like 4
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 54507
neXtProt AC: NX_Q6UY14

Human Synonyms: ADAMTSL-4, ECTOL2, TSRC1

Human Chr (Location): 1q21.3; chr1:150549369-150560937 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human ADAMTSL4

Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(26) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Adamtsl4 interacts with 131 markers (Mir7b, Mir10b, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process apoptotic process, extracellular matrix organization, ...
Component extracellular matrix, extracellular region, ...
Function metalloendopeptidase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (23)    Tissues (16)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 9
RT-PCR 14
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase adamtsl4    NEW 
Molecular
reagents
All nucleic(19) cDNA(17) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000027489 (Evidence)
Ensembl Gene Model ENSMUSG00000015850 (Evidence)
Entrez Gene 229595 (Evidence)
UniGene 490574
DFCI TC1690272, TC1577440
DoTS DT.99856673, DT.99838780
NIA Mouse Gene Index U024367
Consensus CDS Project CCDS17618.1
International Mouse Phenotyping Consortium Status Adamtsl4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027489 VEGA Gene Model | MGI Sequence Detail 11717 C57BL/6J ±  kb
transcript OTTMUST00000068032 VEGA | MGI Sequence Detail 3856 Not Applicable 
polypeptide OTTMUSP00000034318 VEGA | MGI Sequence Detail 1036 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010294 ADAM-TS Spacer 1
InterPro IPR010909 PLAC
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000003741 ADAMTS-like protein 4
References
(Earliest) J:83212 Buchner DA, et al., TSRC1, a widely expressed gene containing seven thrombospondin type I repeats. Gene. 2003 Mar 27;307:23-30
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory