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Adamtsl4 Gene Detail
Summary
  • Symbol
    Adamtsl4
  • Name
    ADAMTS-like 4
  • Synonyms
    Tsrc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2389008
    NCBI Gene: 229595
  • Gene Overview
    MyGene.info: ADAMTSL4
Location & Maps
more
  • Sequence Map
    Chr3:95676201-95687917 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11717 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ADAMTSL4, ADAMTS like 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ADAMTSL4, ADAMTS like 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADAMTSL-4, ECTOL2, TSRC1
  • Links
    NCBI Gene ID: 54507
    neXtProt AC: NX_Q6UY14

  • Chr Location
    1q21.3; chr1:150549369-150560937 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human ADAMTSL4 associations

Human Disease Mouse Models
       Ectopia Lentis 2, Isolated, Autosomal Recessive; ECTOL2   OMIM: 225100
Ectopia Lentis Et Pupillae   OMIM: 225200
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    30
  • Chemically induced (other)
    1
  • Gene trapped
    26
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Adamtsl4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027489 VEGA Gene Model | MGI Sequence Detail 11717 C57BL/6J ±  kb
transcript OTTMUST00000068031 VEGA | MGI Sequence Detail 4036 Not Applicable  
polypeptide OTTMUSP00000034317 VEGA | MGI Sequence Detail 1036 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    67 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 17
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:83212 Buchner DA, et al., TSRC1, a widely expressed gene containing seven thrombospondin type I repeats. Gene. 2003 Mar 27;307:23-30
  • Latest
    J:226844 Collin GB, et al., Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation. Hum Mol Genet. 2015 Dec 15;24(24):6958-74

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory