Klhl11 Gene Detail

Summary

• Symbol
  Klhl11
• Name
  kelch-like 11

• Feature Type
  protein coding gene
• IDs
  MGI:2388648
  NCBI Gene: 217194
• Alliance
  gene page
• Transcription Start Sites
  4 TSS

Location &
Maps

• Sequence Map
  Chr11:100353440-100363567 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 63.47 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  51 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2388648	protein coding gene	Chr11:100347948-100363608 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019157	protein coding gene	Chr11:103223963-103234081 (-)
A/J	MGP_AJ_G0019125	protein coding gene	Chr11:98912212-98922337 (-)
AKR/J	MGP_AKRJ_G0019094	protein coding gene	Chr11:101962301-101972420 (-)
BALB/cJ	MGP_BALBcJ_G0019099	protein coding gene	Chr11:99391872-99401998 (-)
C3H/HeJ	MGP_C3HHeJ_G0018908	protein coding gene	Chr11:102158775-102168900 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019548	protein coding gene	Chr11:106434848-106444971 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017174	protein coding gene	Chr11:96331280-96341402 (-)
CAST/EiJ	MGP_CASTEiJ_G0018462	protein coding gene	Chr11:103126697-103137718 (-)
CBA/J	MGP_CBAJ_G0018877	protein coding gene	Chr11:110862890-110873010 (-)
DBA/2J	MGP_DBA2J_G0018989	protein coding gene	Chr11:98450034-98461217 (-)
FVB/NJ	MGP_FVBNJ_G0018979	protein coding gene	Chr11:97984362-97994482 (-)
LP/J	MGP_LPJ_G0019058	protein coding gene	Chr11:103774808-103784933 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019010	protein coding gene	Chr11:110467598-110477716 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019586	protein coding gene	Chr11:102304347-102314475 (-)
PWK/PhJ	MGP_PWKPhJ_G0018225	protein coding gene	Chr11:99489359-99499530 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018017	protein coding gene	Chr11:102025275-102035606 (-)
WSB/EiJ	MGP_WSBEiJ_G0018511	protein coding gene	Chr11:102288043-102298168 (-)

Homology

• Human Ortholog
  KLHL11, kelch like family member 11

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  KLHL11, kelch like family member 11
  
• Links
  HGNC:19008

  NCBI Gene ID: 55175

  neXtProt AC: NX_Q9NVR0

  UniProt: Q9NVR0

  
  
• Chr Location
  17q21.2; chr17:41848518-41865431 (-)  GRCh38.p7

---

• Alliance of Genome Resources
  Klhl11 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: KLHL11
• Gene Tree
  Klhl11
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  12 phenotype references
  

• All Mutations and Alleles
  7
• Gene trapped
  1
• Targeted
  6
• Genomic Mutations
  3 involving Klhl11
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  18 strains or lines available

Expression

• Assay Results
  672
• cDNA Data
  23

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase klhl11
  ZFIN klhl11

Interactions

• Klhl11 interacts with 65 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

Sequences &
Gene Models

• All Sequences
  32
• RefSeq
  3
• UniProt
  2
• CCDS
  CCDS25424.1

• Ensembl
  ENSMUSG00000048732 (Evidence)
• NCBI Gene
  217194

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000048732	Ensembl Gene Model | MGI Sequence Detail	10128	C57BL/6J
transcript	ENSMUST00000056665	Ensembl | MGI Sequence Detail	2393	Not Applicable
polypeptide	ENSMUSP00000054963	Ensembl | MGI Sequence Detail	709	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000009374 kelch-like protein 11
  (term hierarchy)
• InterPro Domains
  IPR011705 BTB/Kelch-associated
  IPR000210 BTB/POZ domain
  IPR006652 Kelch repeat type 1
  IPR015915 Kelch-type beta propeller
  IPR011333 SKP1/BTB/POZ domain superfamily

Molecular
Reagents

• All nucleic 23

  cDNA 23

  
  

  Microarray probesets 2

References

• Summaries
  All 31

  Phenotypes 12
• Earliest
  J:50799 Liu P, et al., Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics. 1998 Nov;150(3):1155-68
• Latest
  J:232020 Ermakova O, et al., Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice. EMBO Mol Med. 2011 Jan;3(1):50-66

TSS for Klhl11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110821	Chr11:100363620-100363637 (-)	-62 bp
Tssr110820	Chr11:100363598-100363614 (-)	-39 bp
Tssr110819	Chr11:100363588-100363593 (-)	-24 bp
Tssr110818	Chr11:100363551-100363585 (-)	-1 bp