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Wwc1
Gene Detail
 Symbol
Name
ID
Wwc1
WW, C2 and coiled-coil domain containing 1
MGI:2388637
Synonyms Kibra, MGC:47054
Feature Type protein coding gene
Genetic Map
Chromosome 11
21.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:35838400-35980527 bp, - strand
From VEGA annotation of GRCm38

  142128 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69180  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Wwc1

Human
homologs
Human Homolog WWC1, WW and C2 domain containing 1
NCBI Gene ID 23286
neXtProt AC  NX_Q8IX03
Human Synonyms  HBEBP3, HBEBP36, KIBRA, MEMRYQTL, PPP1R168
Human Chr (Location)  5q34; chr5:168292060-168472303 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(10) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired adult synaptic plasticity and fear-based conditioning.
 
Interactions
Wwc1 interacts with 196 markers (Mir7-2, Mir7b, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell migration, negative regulation of hippo signaling, ...
Component cell projection, cytoplasm, ...
Function kinase binding, protein binding, bridging, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23
Assay TypeResults
RNA in situ 24
cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000005418 (Evidence)
Ensembl Gene ModelENSMUSG00000018849 (Evidence)
Entrez Gene211652 (Evidence)
DFCITC1578774, TC1615037, TC1726598
DoTSDT.101378874, DT.488655
NIA Mouse Gene IndexU032655
Consensus CDS ProjectCCDS24545.1
International Mouse Knockout Project StatusWwc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005418 VEGA Gene Model | MGI Sequence Detail 142128 C57BL/6J ±  kb
transcript OTTMUST00000012073 VEGA | MGI Sequence Detail 4531 Not Applicable 
polypeptide OTTMUSP00000005593 VEGA | MGI Sequence Detail 1104 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(1245 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR001202 WW domain
Protein Ontology PR:000017462 protein WWC1
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:207867 Vogt-Eisele A, et al., KIBRA (KIdney/BRAin protein) regulates learning and memory and stabilizes Protein kinase Mzeta. J Neurochem. 2014 Mar;128(5):686-700
All references(39)
Other
accession IDs
MGI:2143978, MGI:2144380

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory