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Wwc1 Gene Detail
Summary
  • Symbol
    Wwc1
  • Name
    WW, C2 and coiled-coil domain containing 1
  • Synonyms
    Kibra, MGC:47054
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388637
    NCBI Gene: 211652
  • Gene Overview
    MyGene.info: WWC1
Location & Maps
more
  • Sequence Map
    Chr11:35838400-35980527 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      142128 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 21.96 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    WWC1, WW and C2 domain containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WWC1, WW and C2 domain containing 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HBEBP3, HBEBP36, KIBRA, MEMRYQTL, PPP1R168
  • Links
    NCBI Gene ID: 23286
    neXtProt AC: NX_Q8IX03

  • Chr Location
    5q34; chr5:168292060-168472303 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 69180
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: WWC1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    10
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Wwc1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit impaired adult synaptic plasticity and fear-based conditioning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005418 VEGA Gene Model | MGI Sequence Detail 142128 C57BL/6J ±  kb
transcript OTTMUST00000012073 VEGA | MGI Sequence Detail 4531 Not Applicable  
polypeptide OTTMUSP00000005593 VEGA | MGI Sequence Detail 1104 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1243 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 6
Other
Accession IDs
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MGI:2143978, MGI:2144380
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:230252 Tracy TE, et al., Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss. Neuron. 2016 Mar 29;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory