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Cltc
Gene Detail
Symbol

Name
ID
Cltc
clathrin, heavy polypeptide (Hc)
MGI:2388633
Synonyms
CHC
Feature Type
protein coding gene
Genetic Map
Chromosome 11
51.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:86694351-86757565 bp, - strand
From VEGA annotation of GRCm38

  63215 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3572  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: CLTC
Protein SuperFamily: clathrin heavy chain
Gene Tree: Cltc

Human
homologs
CLTC, clathrin, heavy chain (Hc)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1213
neXtProt AC: NX_Q00610

Human Synonyms: CHC, CHC17, CLH-17, CLTCL2, Hc

Human Chr (Location): 17q23.1; chr17:59619689-59696956 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(37) Targeted(1)
Genomic Mutations involving Cltc (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Cltc interacts with 302 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process Golgi organization, intracellular protein transport, ...
Component clathrin coat, clathrin-coated vesicle, ...
Function ankyrin binding, clathrin light chain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (3)    Tissues (3)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 3
cDNA source data(770)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cltc ; ZFIN cltca, cltcb    NEW 
Molecular
reagents
All nucleic(773) cDNA(771) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000001209 (Evidence)
Ensembl Gene Model ENSMUSG00000047126 (Evidence)
Entrez Gene 67300 (Evidence)
UniGene 254588
DFCI TC1573863, TC1610319, TC1603962
DoTS DT.101196375, DT.97356413, DT.496029, DT.110522567, DT.110522560
NIA Mouse Gene Index U033227
Consensus CDS Project CCDS25204.1
International Mouse Phenotyping Consortium Status Cltc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001209 VEGA Gene Model | MGI Sequence Detail 63215 C57BL/6J ±  kb
transcript OTTMUST00000002427 VEGA | MGI Sequence Detail 6163 Not Applicable 
polypeptide OTTMUSP00000001193 VEGA | MGI Sequence Detail 1679 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(8) UniProt(9)
Polymorphisms
SNPs within 2kb(237 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR016341 Clathrin, heavy chain
InterPro IPR015348 Clathrin, heavy chain, linker, core motif
InterPro IPR016025 Clathrin, heavy chain, linker/propeller domain
InterPro IPR001473 Clathrin, heavy chain, propeller, N-terminal
InterPro IPR022365 Clathrin, heavy chain, propeller repeat
InterPro IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
InterPro IPR011990 Tetratricopeptide-like helical
Protein Ontology PR:000030907 clathrin heavy chain 1
References
(Earliest) J:59125 Engqvist-Goldstein AE, et al., An actin-binding protein of the Sla2/Huntingtin interacting protein 1 family is a novel component of clathrin-coated pits and vesicles. J Cell Biol. 1999 Dec 27;147(7):1503-18
(Latest) J:216294 Kumar A, et al., Analysis of Presenilin 1 and 2 interacting proteins in mouse cerebral cortex during development. Int J Dev Neurosci. 2014 Nov;38:138-46
All references(61)
Other
accession IDs
MGI:1914550, MGI:2144696

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory