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Cltc
Gene Detail
 Symbol
Name
ID
Cltc
clathrin, heavy polypeptide (Hc)
MGI:2388633
Synonyms CHC
Feature Type protein coding gene
Genetic Map
Chromosome 11
51.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:86694351-86757565 bp, - strand
From VEGA annotation of GRCm38

  63215 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3572  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: clathrin heavy chain
Gene Tree: Cltc

Human
homologs
Human Homolog CLTC, clathrin, heavy chain (Hc)
NCBI Gene ID 1213
neXtProt AC  NX_Q00610
Human Synonyms  CHC, CHC17, CLH-17, CLTCL2, Hc
Human Chr (Location)  17q23.1; chr17:59619689-59696956 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(37) : Gene trapped(37)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Cltc interacts with 302 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process Golgi organization, intracellular protein transport, ...
Component clathrin coat, clathrin-coated vesicle, ...
Function ankyrin binding, clathrin light chain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (3)    Tissues (3)    Images (1)
Theiler Stages: 23, 28
Assay TypeResults
RT-PCR 3
cDNA source data(770)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(773) cDNA(771) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000001209 (Evidence)
Ensembl Gene ModelENSMUSG00000047126 (Evidence)
Entrez Gene67300 (Evidence)
UniGene254588
DFCITC1573863, TC1603962, TC1610319
DoTSDT.101196375, DT.110522560, DT.110522567, DT.496029, DT.97356413
NIA Mouse Gene IndexU033227
Consensus CDS ProjectCCDS25204.1
International Mouse Knockout Project StatusCltc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001209 VEGA Gene Model | MGI Sequence Detail 63215 C57BL/6J ±  kb
transcript OTTMUST00000002427 VEGA | MGI Sequence Detail 6163 Not Applicable 
polypeptide OTTMUSP00000001193 VEGA | MGI Sequence Detail 1679 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(8) UniProt(9)
Polymorphisms SNPs within 2kb(237 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR016341 Clathrin, heavy chain
InterPro IPR015348 Clathrin, heavy chain, linker, core motif
InterPro IPR016025 Clathrin, heavy chain, linker/propeller domain
InterPro IPR001473 Clathrin, heavy chain, propeller, N-terminal
InterPro IPR022365 Clathrin, heavy chain, propeller repeat
InterPro IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
InterPro IPR011990 Tetratricopeptide-like helical
Protein Ontology PR:000030907 clathrin heavy chain 1
References (Earliest) J:59125 Engqvist-Goldstein AE, et al., An actin-binding protein of the Sla2/Huntingtin interacting protein 1 family is a novel component of clathrin-coated pits and vesicles. J Cell Biol. 1999 Dec 27;147(7):1503-18
(Latest) J:183081 Yao LH, et al., Synaptotagmin 1 is necessary for the Ca2+ dependence of clathrin-mediated endocytosis. J Neurosci. 2012 Mar 14;32(11):3778-85
All references(55)
Other
accession IDs
MGI:1914550, MGI:2144696

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory