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Cltc Gene Detail
Summary
  • Symbol
    Cltc
  • Name
    clathrin, heavy polypeptide (Hc)
  • Synonyms
    CHC
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388633
    NCBI Gene: 67300
  • Gene Overview
    MyGene.info: CLTC
Location & Maps
more
  • Sequence Map
    Chr11:86694351-86757565 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      63215 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 51.82 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CLTC, clathrin heavy chain
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CLTC, clathrin heavy chain
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHC, CHC17, CLH-17, CLTCL2, Hc
  • Links
    NCBI Gene ID: 1213
    neXtProt AC: NX_Q00610

  • Chr Location
    17q23.1; chr17:59619689-59696956 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
  • All Mutations and Alleles
    39
  • Chemically induced (other)
    1
  • Gene trapped
    37
  • Targeted
    1
  • Genomic Mutations
    2 involving Cltc
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    3
  • Tissues
    3
  • cDNA Data
    770
  • Literature Summary
    12
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001209 VEGA Gene Model | MGI Sequence Detail 63215 C57BL/6J ±  kb
transcript OTTMUST00000002427 VEGA | MGI Sequence Detail 6163 Not Applicable  
polypeptide OTTMUSP00000001193 VEGA | MGI Sequence Detail 1679 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    238 from dbSNP Build 142
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000030907 clathrin heavy chain 1
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR016341 Clathrin, heavy chain
    IPR015348 Clathrin, heavy chain, linker, core motif
    IPR016025 Clathrin, heavy chain, linker/propeller domain
    IPR001473 Clathrin, heavy chain, propeller, N-terminal
    IPR022365 Clathrin, heavy chain, propeller repeat
    IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
    IPR011990 Tetratricopeptide-like helical domain
Molecular
Reagents
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  • All nucleic 773
    cDNA 771
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1914550, MGI:2144696
References
more
  • Summaries
    All 63
    Developmental Gene Expression 12
    Gene Ontology 13
    Phenotypes 13
  • Earliest
    J:59125 Engqvist-Goldstein AE, et al., An actin-binding protein of the Sla2/Huntingtin interacting protein 1 family is a novel component of clathrin-coated pits and vesicles. J Cell Biol. 1999 Dec 27;147(7):1503-18
  • Latest
    J:230653 Grego-Bessa J, et al., The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium. Elife. 2016;5
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory