Cltc
Gene Detail

Symbol

Name
ID

Cltc
clathrin, heavy polypeptide (Hc)
MGI:2388633

Synonyms

CHC

Feature Type

protein coding gene

Genetic Map

Chromosome 11
51.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:86694351-86757565 bp, - strand From VEGA annotation of GRCm38   63215 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:3572  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: clathrin heavy chain
Gene Tree: Cltc

Human
homologs

Human Homolog		CLTC, clathrin, heavy chain (Hc)
NCBI Gene ID		1213
neXtProt AC		NX_Q00610
Human Synonyms		CHC, CHC17, CLH-17, CLTCL2, Hc
Human Chr (Location)		17q23.1; chr17:59619689-59696956 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(38) : Gene trapped(37) Targeted(1)
Genomic Mutations involving Cltc (1)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Cltc interacts with 302 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (45 annotations)

Process	Golgi organization, intracellular protein transport, ...
Component	clathrin coat, clathrin-coated vesicle, ...
Function	ankyrin binding, clathrin light chain binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)

Data Summary: Results (3)    Tissues (3)    Images (1)    Tissue x Stage Matrix (view)

Assay Type	Results
RT-PCR	3

cDNA source data(770)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(773) cDNA(771) Primer pair(2)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000001209 (Evidence)
Ensembl Gene Model	ENSMUSG00000047126 (Evidence)
Entrez Gene	67300 (Evidence)
UniGene	254588
DFCI	TC1610319, TC1573863, TC1603962
DoTS	DT.110522567, DT.110522560, DT.101196375, DT.496029, DT.97356413
NIA Mouse Gene Index	U033227
Consensus CDS Project	CCDS25204.1
International Mouse Knockout Project Status	Cltc

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001209	VEGA Gene Model | MGI Sequence Detail	63215	C57BL/6J
transcript	OTTMUST00000002427	VEGA | MGI Sequence Detail	6163	Not Applicable
polypeptide	OTTMUSP00000001193	VEGA | MGI Sequence Detail	1679	Not Applicable

All sequences(73) RefSeq(8) UniProt(17)

Polymorphisms

SNPs within 2kb(237 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR016341	Clathrin, heavy chain
InterPro	IPR015348	Clathrin, heavy chain, linker, core motif
InterPro	IPR016025	Clathrin, heavy chain, linker/propeller domain
InterPro	IPR001473	Clathrin, heavy chain, propeller, N-terminal
InterPro	IPR022365	Clathrin, heavy chain, propeller repeat
InterPro	IPR000547	Clathrin, heavy chain/VPS, 7-fold repeat
InterPro	IPR011990	Tetratricopeptide-like helical
Protein Ontology	PR:000030907	clathrin heavy chain 1

References

(Earliest) J:59125 Engqvist-Goldstein AE, et al., An actin-binding protein of the Sla2/Huntingtin interacting protein 1 family is a novel component of clathrin-coated pits and vesicles. J Cell Biol. 1999 Dec 27;147(7):1503-18
(Latest) J:216294 Kumar A, et al., Analysis of Presenilin 1 and 2 interacting proteins in mouse cerebral cortex during development. Int J Dev Neurosci. 2014 Nov;38:138-46
All references(60)

Other
accession IDs

MGI:1914550, MGI:2144696