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Cltc Gene Detail
Summary
  • Symbol
    Cltc
  • Name
    clathrin, heavy polypeptide (Hc)
  • Synonyms
    CHC
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388633
    NCBI Gene: 67300
  • Gene Overview
    MyGene.info: CLTC
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:86694610-86757742 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 51.82 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    238 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2388633
 protein coding gene Chr11:86694351-86757742 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018894
 protein coding gene Chr11:88268495-88334972 (-)
A/J MGP_AJ_G0018861
 protein coding gene Chr11:84874119-84938601 (-)
AKR/J MGP_AKRJ_G0018831
 protein coding gene Chr11:87413828-87479520 (-)
BALB/cJ MGP_BALBcJ_G0018834
 protein coding gene Chr11:85255838-85318929 (-)
C3H/HeJ MGP_C3HHeJ_G0018648
 protein coding gene Chr11:87435554-87511791 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019286
 protein coding gene Chr11:90929597-90996336 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016919
 protein coding gene Chr11:81894396-81957082 (-)
CAST/EiJ MGP_CASTEiJ_G0018203
 protein coding gene Chr11:88129399-88197594 (-)
CBA/J MGP_CBAJ_G0018619
 protein coding gene Chr11:94755066-94824211 (-)
DBA/2J MGP_DBA2J_G0018727
 protein coding gene Chr11:84443106-84506563 (-)
FVB/NJ MGP_FVBNJ_G0018716
 protein coding gene Chr11:83944439-84006676 (-)
LP/J MGP_LPJ_G0018797
 protein coding gene Chr11:88756840-88822770 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018743
 protein coding gene Chr11:94859730-94926683 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019326
 protein coding gene Chr11:87657155-87725547 (-)
PWK/PhJ MGP_PWKPhJ_G0017973
 protein coding gene Chr11:85239673-85305280 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017765
 protein coding gene Chr11:87211500-87276704 (-)
WSB/EiJ MGP_WSBEiJ_G0018254
 protein coding gene Chr11:87529691-87596700 (-)



Homology
more
  • Human Ortholog
    CLTC, clathrin heavy chain
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CLTC, clathrin heavy chain
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHC, CHC17, CLH-17, CLTCL2, Hc, MRD56
  • Links
    NCBI Gene ID: 1213
    neXtProt AC: NX_Q00610
    UniProt: Q00610

  • Chr Location
    17q23.1; chr17:59619689-59696956 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human CLTC associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    78
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    6
  • Tissues
    5
  • cDNA Data
    771
  • Literature Summary
    19
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67300 NCBI Gene Model | MGI Sequence Detail 63133 C57BL/6J ±  kb
transcript NM_001356393 RefSeq | MGI Sequence Detail 6563 C57BL/6  
polypeptide Q68FD5 UniProt | EBI | MGI Sequence Detail 1675 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    9 Sequences
  • PDB
    5ODS
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR016341 Clathrin, heavy chain
    IPR015348 Clathrin, heavy chain, linker, core motif
    IPR016025 Clathrin heavy chain, N-terminal
    IPR022365 Clathrin, heavy chain, propeller repeat
    IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
    IPR011990 Tetratricopeptide-like helical domain superfamily
Molecular
Reagents
less
  • All nucleic 774
    cDNA 772
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1914550, MGI:2144696
References
more
  • Summaries
    All 90
    Developmental Gene Expression 19
    Gene Ontology 18
    Phenotypes 14
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:266273 Honda A, et al., FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8388-8393
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
01/08/2019
MGI 6.13 		The Jackson Laboratory