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Ppp2r5d Gene Detail
Summary
  • Symbol
    Ppp2r5d
  • Name
    protein phosphatase 2, regulatory subunit B', delta
  • Synonyms
    B'delta, TEG-271, Tex271
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388481
    NCBI Gene: 21770
  • Gene Overview
    MyGene.info: PPP2R5D
Location & Maps
more
  • Sequence Map
    Chr17:46682991-46705002 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22012 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 22.90 cM, cytoband C
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PPP2R5D, protein phosphatase 2 regulatory subunit B'delta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PPP2R5D, protein phosphatase 2 regulatory subunit B'delta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    B56D, MRD35
  • Links
    NCBI Gene ID: 5528
    neXtProt AC: NX_Q14738

  • Chr Location
    6p21.1; chr6:42984499-43012345 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PPP2R5D associations

Human Disease Mouse Models
       Mental Retardation, Autosomal Dominant 35; MRD35   OMIM: 616355
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trap allele exhibit lethality, while heterozygous mice display decreased prepulse inhibition. Mice homozygous for a targeted knock-out allele exhibit decreased thermal nociception threshold, impaired coordination, and increasedlatency to removing an adhesive sticker.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059409 Ensembl Gene Model | MGI Sequence Detail 22012 C57BL/6J ±  kb
transcript ENSMUST00000002839 Ensembl | MGI Sequence Detail 2926 Not Applicable  
polypeptide ENSMUSP00000002839 Ensembl | MGI Sequence Detail 594 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    80 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR002554 Protein phosphatase 2A, regulatory B subunit, B56
Molecular
Reagents
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  • All nucleic 6
    cDNA 5
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGI:1096565
References
more
  • Summaries
    All 31
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 9
  • Earliest
    J:35463 Lopez-Fernandez LA, et al., Characterization of genes expressed early in mouse spermatogenesis, isolated from a subtractive cDNA library. Mamm Genome. 1996 Sep;7(9):698-700
  • Latest
    J:188568 Tadmouri A, et al., Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy. EMBO J. 2012 Sep 12;31(18):3730-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory