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Ppp2r5a Gene Detail
Summary
  • Symbol
    Ppp2r5a
  • Name
    protein phosphatase 2, regulatory subunit B', alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388479
    NCBI Gene: 226849
  • Gene Overview
    MyGene.info: PPP2R5A
Location & Maps
more
  • Sequence Map
    Chr1:191351975-191403272 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51298 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 96.28 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PPP2R5A, protein phosphatase 2 regulatory subunit B'alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPP2R5A, protein phosphatase 2 regulatory subunit B'alpha
    Orthology source: HGNC, HomoloGene
  • Synonyms
    B56A, PR61A
  • Links
    NCBI Gene ID: 5525
    neXtProt AC: NX_Q15172

  • Chr Location
    1q32.2-q32.3; chr1:212285537-212361863 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    28
  • Gene trapped
    26
  • Targeted
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051528 VEGA Gene Model | MGI Sequence Detail 51298 C57BL/6J ±  kb
transcript OTTMUST00000130136 VEGA | MGI Sequence Detail 3088 Not Applicable  
polypeptide OTTMUSP00000069805 VEGA | MGI Sequence Detail 486 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    444 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013143 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR002554 Protein phosphatase 2A, regulatory B subunit, B56
Molecular
Reagents
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  • All nucleic 95
    cDNA 94
    Primer pair 1

    Microarray probesets 11
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:218294 Kirchhefer U, et al., Cardiac function is regulated by B56alpha-mediated targeting of protein phosphatase 2A (PP2A) to contractile relevant substrates. J Biol Chem. 2014 Dec 5;289(49):33862-73

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory