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Otop2 Gene Detail
Summary
  • Symbol
    Otop2
  • Name
    otopetrin 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388365
    NCBI Gene: 237987
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:115307163-115332303 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 80.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2388365
protein coding gene Chr11:115307163-115332306 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019379
protein coding gene Chr11:119324881-119350273 (+)
A/J MGP_AJ_G0019348
protein coding gene Chr11:114110322-114135824 (+)
AKR/J MGP_AKRJ_G0019318
protein coding gene Chr11:117514933-117540077 (+)
BALB/cJ MGP_BALBcJ_G0019322
protein coding gene Chr11:114526328-114551735 (+)
C3H/HeJ MGP_C3HHeJ_G0019128
protein coding gene Chr11:117869749-117894881 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019772
protein coding gene Chr11:122964461-122989590 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017395
protein coding gene Chr11:111151875-111177871 (+)
CAST/EiJ MGP_CASTEiJ_G0018683
protein coding gene Chr11:119180929-119206203 (+)
CBA/J MGP_CBAJ_G0019100
protein coding gene Chr11:127811623-127840949 (+)
DBA/2J MGP_DBA2J_G0019211
protein coding gene Chr11:113548531-113573995 (+)
FVB/NJ MGP_FVBNJ_G0019203
protein coding gene Chr11:113022524-113048735 (+)
LP/J MGP_LPJ_G0019281
protein coding gene Chr11:119704637-119731048 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019236
protein coding gene Chr11:126986560-127012786 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019810
protein coding gene Chr11:118175424-118200577 (+)
PWK/PhJ MGP_PWKPhJ_G0018447
protein coding gene Chr11:114828401-114854291 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018240
protein coding gene Chr11:117915424-117940874 (+)
WSB/EiJ MGP_WSBEiJ_G0018735
protein coding gene Chr11:118122494-118147674 (+)



Homology
more
  • Human Ortholog
    OTOP2, otopetrin 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    OTOP2, otopetrin 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 92736
    neXtProt AC: NX_Q7RTS6
    UniProt: Q7RTS6

  • Chr Location
    17q25.1; chr17:74922963-74933913 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 27803
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;2 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: OTOP2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050201 Ensembl Gene Model | MGI Sequence Detail 25141 C57BL/6J ±  kb
transcript ENSMUST00000055490 Ensembl | MGI Sequence Detail 2335 Not Applicable  
polypeptide ENSMUSP00000062109 Ensembl | MGI Sequence Detail 563 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 2
References
more
  • Summaries
    All 21
    Gene Ontology 2
    Phenotypes 2
  • Earliest
    J:82022 Kikkawa Y, et al., Mutations in a new scaffold protein Sans cause deafness in Jackson shaker mice. Hum Mol Genet. 2003 Mar 1;12(5):453-61
  • Latest
    J:259123 Tu YH, et al., An evolutionarily conserved gene family encodes proton-selective ion channels. Science. 2018 Mar 2;359(6379):1047-1050

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory