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Acsf2 Gene Detail
Summary
  • Symbol
    Acsf2
  • Name
    acyl-CoA synthetase family member 2
  • Synonyms
    MGC:25878
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388287
    NCBI Gene: 264895
Location & Maps
more
  • Sequence Map
    Chr11:94557102-94601871 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      44770 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 58.90 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ACSF2, acyl-CoA synthetase family member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACSF2, acyl-CoA synthetase family member 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACSMW, AVYV493
  • Links
    NCBI Gene ID: 80221
    neXtProt AC: NX_Q96CM8

  • Chr Location
    17q21.33; chr17:50426158-50474845 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 23519
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ACSF2
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    4
  • Targeted
    6
  • Genomic Mutations
    4 involving Acsf2
  • Incidental Mutations
Phenotypic analysis of mice homozygous for a gene trap allele indicates this mutation has no notable phenotype in any parameter tested.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002019 VEGA Gene Model | MGI Sequence Detail 44770 C57BL/6J ±  kb
transcript OTTMUST00000004072 VEGA | MGI Sequence Detail 3154 Not Applicable  
polypeptide OTTMUSP00000001958 VEGA | MGI Sequence Detail 615 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    451 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000003657 acyl-CoA synthetase family member 2, mitochondrial
  • EC
  • InterPro Domains
    IPR020845 AMP-binding, conserved site
    IPR025110 AMP-binding enzyme C-terminal domain
    IPR000873 AMP-dependent synthetase/ligase
Molecular
Reagents
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  • All nucleic 26
    Genomic 1
    cDNA 25

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory