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Plekhg3 Gene Detail
Summary
  • Symbol
    Plekhg3
  • Name
    pleckstrin homology domain containing, family G (with RhoGef domain) member 3
  • Synonyms
    MGC40768
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388284
    NCBI Gene: 263406
Location & Maps
more
  • Sequence Map
    Chr12:76533560-76579039 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45480 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PLEKHG3, pleckstrin homology and RhoGEF domain containing G3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PLEKHG3, pleckstrin homology and RhoGEF domain containing G3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARHGEF43, KIAA0599
  • Links
    NCBI Gene ID: 26030
    neXtProt AC: NX_A1L390

  • Chr Location
    14q23.3; chr14:64704413-64746905 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    47
  • Chemically induced (other)
    1
  • Gene trapped
    42
  • Targeted
    4
  • Genomic Mutations
    1 involving Plekhg3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052609 Ensembl Gene Model | MGI Sequence Detail 45480 C57BL/6J ±  kb
transcript ENSMUST00000075249 Ensembl | MGI Sequence Detail 4955 Not Applicable  
polypeptide ENSMUSP00000074729 Ensembl | MGI Sequence Detail 1341 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    227 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000031320 pleckstrin homology domain-containing family G member 3
  • InterPro Domains
    IPR000219 Dbl homology (DH) domain
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
Molecular
Reagents
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  • All nucleic 46
    cDNA 46

    Microarray probesets 1
References
more
  • Summaries
    All 25
    Developmental Gene Expression 2
    Gene Ontology 1
    Phenotypes 11
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:224530 Dietrich JE, et al., Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. EMBO Rep. 2015 Aug;16(8):1005-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory