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Plekhg3 Gene Detail
Summary
  • Symbol
    Plekhg3
  • Name
    pleckstrin homology domain containing, family G (with RhoGef domain) member 3
  • Synonyms
    MGC40768
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388284
    NCBI Gene: 263406
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:76533246-76580489 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      47244 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 33.73 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PLEKHG3, pleckstrin homology and RhoGEF domain containing G3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PLEKHG3, pleckstrin homology and RhoGEF domain containing G3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARHGEF43, KIAA0599
  • Links
    NCBI Gene ID: 26030
    neXtProt AC: NX_A1L390
    UniProt: A1L390

  • Chr Location
    14q23.3; chr14:64704129-64744346 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 263406 NCBI Gene Model | MGI Sequence Detail 47244 C57BL/6J ±  kb
    transcript NM_153804 RefSeq | MGI Sequence Detail 4955 C57BL/6  
    polypeptide Q4VAC9 UniProt | EBI | MGI Sequence Detail 1341 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      235 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 46

      Microarray probesets 1
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 2
      Gene Ontology 1
      Phenotypes 13
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory