Retreg2 Gene Detail

Summary

• Symbol
  Retreg2
• Name
  reticulophagy regulator family member 2
• Synonyms
  Fam134a, MGC47289

• Feature Type
  protein coding gene
• IDs
  MGI:2388278
  NCBI Gene: 227298
• Alliance
  gene page
• Transcription Start Sites
  11 TSS

Location &
Maps

• Sequence Map
  Chr1:75119422-75124557 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 38.61 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  12 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2388278	protein coding gene	Chr1:75119364-75124557 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016172	protein coding gene	Chr1:75703690-75708867 (+)
A/J	MGP_AJ_G0016155	protein coding gene	Chr1:73063564-73068684 (+)
AKR/J	MGP_AKRJ_G0016112	protein coding gene	Chr1:75092052-75097180 (+)
BALB/cJ	MGP_BALBcJ_G0016110	protein coding gene	Chr1:73126798-73131933 (+)
C3H/HeJ	MGP_C3HHeJ_G0015941	protein coding gene	Chr1:75423380-75428513 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016563	protein coding gene	Chr1:78655571-78660701 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014284	protein coding gene	Chr1:68626534-68631668 (+)
CAST/EiJ	MGP_CASTEiJ_G0015525	protein coding gene	Chr1:74760185-74765261 (+)
CBA/J	MGP_CBAJ_G0015914	protein coding gene	Chr1:81209109-81214240 (+)
DBA/2J	MGP_DBA2J_G0016015	protein coding gene	Chr1:72383451-72388574 (+)
FVB/NJ	MGP_FVBNJ_G0016018	protein coding gene	Chr1:71579882-71585851 (+)
LP/J	MGP_LPJ_G0016087	protein coding gene	Chr1:76827524-76832660 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016038	protein coding gene	Chr1:84570228-84575369 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016610	protein coding gene	Chr1:75160448-75165584 (+)
PWK/PhJ	MGP_PWKPhJ_G0015312	protein coding gene	Chr1:71851699-71856851 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015090	protein coding gene	Chr1:74522714-74527822 (+)
WSB/EiJ	MGP_WSBEiJ_G0015587	protein coding gene	Chr1:74973854-74978987 (+)

Homology

• Human Ortholog
  RETREG2, reticulophagy regulator family member 2

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  RETREG2, reticulophagy regulator family member 2
  
• Synonyms
  C2orf17, FAM134A, MAG-2
• Links
  HGNC:28450

  NCBI Gene ID: 79137

  neXtProt AC: NX_Q8NC44

  UniProt: Q8NC44

  
  
• Chr Location
  2q35; chr2:219178190-219185475 (+)  GRCh38.p7

---

• Alliance of Genome Resources
  Retreg2 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: RETREG2
• Gene Tree
  Retreg2
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotypes from 1 allele in 1 genetic background
  21 phenotype references
  

• All Mutations and Alleles
  6
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Radiation induced
  2
• Spontaneous
  1
• Targeted
  1
• Genomic Mutations
  4 involving Retreg2
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  15 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Gene Ontology
(GO)
Classifications

• All GO Annotations
  2
• GO References
  2

Expression

• Assay Results
  820
• Tissues
  48
• cDNA Data
  12
• Literature Summary
  3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase retreg2

Interactions

• Retreg2 interacts with 175 markers (Mir1b, Mir9-1, Mir9-2, ...) View All

Sequences &
Gene Models

• All Sequences
  78
• RefSeq
  10
• UniProt
  6
• CCDS
  CCDS35621.1, CCDS78621.1

• Ensembl
  ENSMUSG00000049339 (Evidence)
• NCBI Gene
  227298

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000049339	Ensembl Gene Model | MGI Sequence Detail	5136	C57BL/6J
transcript	ENSMUST00000097694	Ensembl | MGI Sequence Detail	2561	Not Applicable
polypeptide	ENSMUSP00000095300	Ensembl | MGI Sequence Detail	541	Not Applicable

Protein
Information

• UniProt
  6 Sequences
• Protein Ontology
  PR:000031519 reticulophagy regulator 2
  (term hierarchy)

Molecular
Reagents

• All nucleic 12

  cDNA 12

  
  

  Microarray probesets 3

References

• Summaries
  All 44

  Developmental Gene Expression 3

  Diseases 1

  Gene Ontology 2

  Phenotypes 21
• Earliest
  J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
• Latest
  J:260073 Will AJ, et al., Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog). Nat Genet. 2017 Oct;49(10):1539-1545

TSS for Retreg2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7484	Chr1:75118277-75118349 (+)	-1,109 bp
Tssr7485	Chr1:75118431-75118442 (+)	-985 bp
Tssr7486	Chr1:75119077-75119127 (+)	-320 bp
Tssr7487	Chr1:75119146-75119163 (+)	-267 bp
Tssr7488	Chr1:75119362-75119386 (+)	-48 bp
Tssr7489	Chr1:75119406-75119417 (+)	-10 bp
Tssr7490	Chr1:75119419-75119441 (+)	8 bp
Tssr7491	Chr1:75119457-75119468 (+)	41 bp
Tssr7492	Chr1:75119472-75119481 (+)	55 bp
Tssr7493	Chr1:75119887-75119915 (+)	479 bp
Tssr7494	Chr1:75123942-75123962 (+)	4,530 bp