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Fam20a
Gene Detail
 Symbol
Name
ID
Fam20a
family with sequence similarity 20, member A
MGI:2388266
Feature Type protein coding gene
Genetic Map
Chromosome 11
72.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:109669749-109722279 bp, - strand
From VEGA annotation of GRCm38

  52531 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9719  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Fam20a

Human
homologs
Human Homolog FAM20A, family with sequence similarity 20, member A
NCBI Gene ID 54757
neXtProt AC  NX_Q96MK3
Human Synonyms  AI1G, AIGFS, FP2747
Human Chr (Location)  17q24.2; chr17:68535116-68600954 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FAM20A
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal ameloblast morphology, disrupted dental enamel formation in both incisor and molar teeth, abnormal kidney morphology, disseminated calcifications of muscular arteries, and intrapulmonary calcifications.
 
Interactions
Fam20a interacts with 164 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process calcium ion homeostasis, enamel mineralization, ...
Component cell, extracellular region, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(67)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(67) cDNA(67)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000003353 (Evidence)
Ensembl Gene ModelENSMUSG00000020614 (Evidence)
Entrez Gene208659 (Evidence)
UniGene208662
DFCITC1577195
DoTSDT.40144043, DT.87048303
NIA Mouse Gene IndexU033573
Consensus CDS ProjectCCDS25584.1
International Mouse Knockout Project StatusFam20a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003353 VEGA Gene Model | MGI Sequence Detail 52531 C57BL/6J ±  kb
transcript OTTMUST00000007049 VEGA | MGI Sequence Detail 2541 Not Applicable 
polypeptide OTTMUSP00000003356 VEGA | MGI Sequence Detail 541 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(5) UniProt(1)
Polymorphisms SNPs within 2kb(137 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009581 Domain of unknown function DUF1193
InterPro IPR024869 FAM20
Protein Ontology PR:000031680 protein FAM20A
References (Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:211232 Wang SK, et al., FAM20A mutations can cause enamel-renal syndrome (ERS). PLoS Genet. 2013;9(2):e1003302
All references(36)
Other
accession IDs
MGI:2144241

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory