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Fam20a
Gene Detail
Symbol

Name
ID
Fam20a
family with sequence similarity 20, member A
MGI:2388266
Feature Type
protein coding gene
Genetic Map
Chromosome 11
72.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:109669749-109722279 bp, - strand
From VEGA annotation of GRCm38

  52531 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9719  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FAM20A
Gene Tree: Fam20a

Human
homologs
FAM20A, family with sequence similarity 20, member A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 54757
neXtProt AC: NX_Q96MK3

Human Synonyms: AI1G, AIGFS, FP2747

Human Chr (Location): 17q24.2; chr17:68534561-68600954 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FAM20A

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit abnormal ameloblast morphology, disrupted dental enamel formation in both incisor and molar teeth, abnormal kidney morphology, disseminated calcifications of muscular arteries, and intrapulmonary calcifications.
 
Interactions
Fam20a interacts with 164 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process biomineral tissue development, calcium ion homeostasis, ...
Component cell, endoplasmic reticulum, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(67)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fam20a    NEW 
Molecular
reagents
All nucleic(67) cDNA(67)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000003353 (Evidence)
Ensembl Gene Model ENSMUSG00000020614 (Evidence)
Entrez Gene 208659 (Evidence)
UniGene 208662
DFCI TC1577195
DoTS DT.40144043, DT.87048303
NIA Mouse Gene Index U033573
Consensus CDS Project CCDS25584.1
International Mouse Phenotyping Consortium Status Fam20a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003353 VEGA Gene Model | MGI Sequence Detail 52531 C57BL/6J ±  kb
transcript OTTMUST00000007030 VEGA | MGI Sequence Detail 3085 Not Applicable 
polypeptide OTTMUSP00000045543 VEGA | MGI Sequence Detail 541 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(5) UniProt(1)
Polymorphisms
SNPs within 2kb(137 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024869 FAM20
InterPro IPR009581 FAM20, C-terminal
Protein Ontology PR:000031680 protein FAM20A
References
(Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:222164 Cui J, et al., A secretory kinase complex regulates extracellular protein phosphorylation. Elife. 2015;4:e06120
All references(37)
Other
accession IDs
MGI:2144241

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory