Liph
Gene Detail

Symbol Name ID

Liph lipase, member H MGI:2388029

Synonyms

C130037N08Rik, D16Wsu119e, Lpdlr, LPDLR, mPA-PLA1, PLA1B

Feature Type

protein coding gene

Genetic Map

Chromosome 16

12.95 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr16:21953826-21995542 bp, - strand From Ensembl annotation of GRCm38   41717 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:71802  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: lipoprotein lipase, LIPH type
Gene Tree: Liph

Human homologs

Human Homolog		LIPH, lipase, member H
NCBI Gene ID		200879
neXtProt AC		NX_Q8WWY8
Human Synonyms		AH, ARWH2, LAH2, LPDLR, mPA-PLA1, PLA1B
Human Chr (Location)		3q27; chr3:185225570-185270369 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LIPH

Alleles and phenotypes

All alleles(15) : Targeted(2) Gene trapped(13)
 

Mice homozygous for a knock-out allele exhibit wavy vibrissae and wavy and matted coats associated with impaired inner rooth sheath formation.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	lipid catabolic process, lipid metabolic process
Component	extracellular region, extracellular space, ...
Function	catalytic activity, heparin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (103)    Tissues (16)    Images (40)
Theiler Stages: 11, 23

Assay Type	Results
RNA in situ	97
RT-PCR	6

cDNA source data(38)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(49) Genomic(6) cDNA(38) Primer pair(1) Other(4)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000044626 (Evidence)
Entrez Gene	239759 (Evidence)
UniGene	33192
DFCI	TC1583730, TC1590154, TC1598904, TC1642311, TC1657737, TC1678678
DoTS	DT.101332126, DT.521528, DT.91565487
NIA Mouse Gene Index	U036908
EC	3.1.1.-
Consensus CDS Project	CCDS37295.1, CCDS37296.1
International Mouse Knockout Project Status	Liph

Sequences

Length	Strain/Species
genomic	ENSMUSG00000044626	Ensembl Gene Model | MGI Sequence Detail	41717	C57BL/6J
transcript	ENSMUST00000060673	Ensembl | MGI Sequence Detail	3793	Not Applicable
polypeptide	ENSMUSP00000062310	Ensembl | MGI Sequence Detail	451	Not Applicable

All sequences(38) RefSeq(4) UniProt(1)

Polymorphisms

RFLP(2) : SNPs(123 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000734	Lipase
InterPro	IPR013818	Lipase, N-terminal
InterPro	IPR016272	Lipoprotein lipase, LIPH
Protein Ontology	PR:000009837	lipase member H

References

(Earliest) J:37738 Kalcheva I, et al., The gene encoding beta-galactoside alpha2,6-sialyltransferase maps to mouse chromosome 16. Mamm Genome. 1997 Aug;8(8):619-20
(Latest) J:177192 Inoue A, et al., LPA-producing enzyme PA-PLA(1)alpha regulates hair follicle development by modulating EGFR signalling. EMBO J. 2011;30(20):4248-60
All references(42)

Other accession IDs

MGD-MRK-35700, MGI:107235, MGI:1206038, MGI:1206041, MGI:2444423