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Sema6d
Gene Detail
Symbol

Name
ID
Sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
MGI:2387661
Synonyms
1110067B02Rik, mKIAA1479, Sema6D-1, Sema6D-2, Sema6D-4, Sema6D-5, Sema6D-6
Feature Type
protein coding gene
Genetic Map
Chromosome 2
60.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:124089969-124667770 bp, + strand
From VEGA annotation of GRCm38

  577802 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16195  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SEMA6D
Protein SuperFamily: semaphorin
Gene Tree: Sema6d

Human
homologs
SEMA6D, sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 80031
neXtProt AC: NX_Q8NFY4

Human Chr (Location): 15q21.1; chr15:47184101-47774223 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit normal dendritic cell trafficking and antigen-specific T cell priming.
 
Interactions
Sema6d interacts with 352 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell differentiation, multicellular organismal development, ...
Component integral component of membrane, membrane, ...
Function protein binding, semaphorin receptor binding
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (319)    Tissues (91)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 319
cDNA source data(12)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase sema6d    NEW 
Molecular
reagents
All nucleic(14) cDNA(13) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000015256 (Evidence)
Ensembl Gene Model ENSMUSG00000027200 (Evidence)
Entrez Gene 214968 (Evidence)
DFCI TC1664620, TC1604456, TC1578641, TC1601351, TC1588584, TC1712394, TC1601288, TC1594841, TC1602887
DoTS DT.91318249, DT.522834, DT.103567243, DT.110692721, DT.103567239, DT.101736718, DT.101394682, DT.91378815
NIA Mouse Gene Index U002402
Consensus CDS Project CCDS16670.1, CCDS16671.1, CCDS16672.1, CCDS16673.1, CCDS38225.1, CCDS71132.1
International Mouse Phenotyping Consortium Status Sema6d
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015256 VEGA Gene Model | MGI Sequence Detail 577802 C57BL/6J ±  kb
transcript OTTMUST00000036150 VEGA | MGI Sequence Detail 6225 Not Applicable 
polypeptide OTTMUSP00000016242 VEGA | MGI Sequence Detail 1073 Not Applicable 

For the selected sequences
All sequences(116) RefSeq(40) UniProt(3)
Polymorphisms
SNPs within 2kb(2647 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002165 Plexin
InterPro IPR016201 Plexin-like fold
InterPro IPR027231 Semaphorin
InterPro IPR001627 Semaphorin/CD100 antigen
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000014632 semaphorin-6D
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:213126 O'Donovan KJ, et al., B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS. J Exp Med. 2014 May 5;211(5):801-14
All references(47)
Other
accession IDs
MGI:1916098, MGI:2138763

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory