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Katnal1 Gene Detail
Summary
  • Symbol
    Katnal1
  • Name
    katanin p60 subunit A-like 1
  • Synonyms
    MGC:40859
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387638
    NCBI Gene: 231912
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:148871584-148929160 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 89.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    328 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387638
 protein coding gene Chr5:148871584-148929320 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030397
 protein coding gene Chr5:154649908-154712068 (-)
A/J MGP_AJ_G0030370
 protein coding gene Chr5:148063251-148120502 (-)
AKR/J MGP_AKRJ_G0030297
 protein coding gene Chr5:152626403-152683869 (-)
BALB/cJ MGP_BALBcJ_G0030379
 protein coding gene Chr5:149310632-149371175 (-)
C3H/HeJ MGP_C3HHeJ_G0030093
 protein coding gene Chr5:153614788-153676013 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030834
 protein coding gene Chr5:160342603-160406030 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028047
 protein coding gene Chr5:142437662-142493189 (-)
CAST/EiJ MGP_CASTEiJ_G0029495
 protein coding gene Chr5:153200052-153265397 (-)
CBA/J MGP_CBAJ_G0030071
 protein coding gene Chr5:167031457-167097374 (-)
DBA/2J MGP_DBA2J_G0030215
 protein coding gene Chr5:147726342-147783121 (-)
FVB/NJ MGP_FVBNJ_G0030169
 protein coding gene Chr5:146965443-147023160 (-)
LP/J MGP_LPJ_G0030302
 protein coding gene Chr5:155333586-155395445 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030205
 protein coding gene Chr5:169218930-169279586 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030864
 protein coding gene Chr5:152555405-152615896 (-)
PWK/PhJ MGP_PWKPhJ_G0029209
 protein coding gene Chr5:146868395-146928439 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029045
 protein coding gene Chr5:149854014-149915234 (-)
WSB/EiJ MGP_WSBEiJ_G0029572
 protein coding gene Chr5:153367349-153427041 (-)



Homology
more
  • Human Ortholog
    KATNAL1, katanin catalytic subunit A1 like 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KATNAL1, katanin catalytic subunit A1 like 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 84056
    neXtProt AC: NX_Q9BW62
    UniProt: Q9BW62

  • Chr Location
    13q12.3; chr13:30202626-30307500 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    4 images
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU induced mutation display male infertility with decreased testis weight and premature exfoliation of spermatids from the seminiferous epithelium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    14
  • Tissues
    11
  • cDNA Data
    26
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 231912 NCBI Gene Model | MGI Sequence Detail 57577 C57BL/6J ±  kb
    transcript NM_153572 RefSeq | MGI Sequence Detail 6173 C57BL/6  
    polypeptide Q8K0T4 UniProt | EBI | MGI Sequence Detail 488 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 26
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 22
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 4
    • Earliest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
    • Latest
      J:262184 Banks G, et al., A missense mutation in Katnal1 underlies behavioural, neurological and ciliary anomalies. Mol Psychiatry. 2018 Mar;23(3):713-722
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    08/06/2019
    MGI 6.14     		The Jackson Laboratory