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Erlin1 Gene Detail
Summary
  • Symbol
    Erlin1
  • Name
    ER lipid raft associated 1
  • Synonyms
    2810439N09Rik, Keo4, Spfh1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387613
    NCBI Gene: 226144
  • Gene Overview
    MyGene.info: ERLIN1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:44034944-44069785 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 36.70 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    286 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387613
protein coding gene Chr19:44034943-44070494 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025162
protein coding gene Chr19:43486684-43521804 (-)
A/J MGP_AJ_G0025139
protein coding gene Chr19:41408443-41443447 (-)
AKR/J MGP_AKRJ_G0025107
protein coding gene Chr19:42719717-42754883 (-)
BALB/cJ MGP_BALBcJ_G0025133
protein coding gene Chr19:41453812-41488789 (-)
C3H/HeJ MGP_C3HHeJ_G0024893
protein coding gene Chr19:42892979-42929723 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025576
protein coding gene Chr19:44549542-44586346 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022990
protein coding gene Chr19:40699540-40735786 (-)
CAST/EiJ MGP_CASTEiJ_G0024358
protein coding gene Chr19:42605163-42640970 (-)
CBA/J MGP_CBAJ_G0024873
protein coding gene Chr19:46768444-46807605 (-)
DBA/2J MGP_DBA2J_G0025005
protein coding gene Chr19:41233385-41269425 (-)
FVB/NJ MGP_FVBNJ_G0024966
protein coding gene Chr19:40994699-41030182 (-)
LP/J MGP_LPJ_G0025091
protein coding gene Chr19:43443524-43480956 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024997
protein coding gene Chr19:46285629-46322378 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025634
protein coding gene Chr19:42805418-42844420 (-)
PWK/PhJ MGP_PWKPhJ_G0024107
protein coding gene Chr19:41134730-41170215 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023911
protein coding gene Chr19:41520575-41556548 (-)
WSB/EiJ MGP_WSBEiJ_G0024428
protein coding gene Chr19:42947107-42983860 (-)



Homology
more
  • Human Ortholog
    ERLIN1, ER lipid raft associated 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ERLIN1, ER lipid raft associated 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C10orf69, Erlin-1, KE04, KEO4, SPFH1, SPG62
  • Links
    NCBI Gene ID: 10613
    neXtProt AC: NX_O75477
    UniProt: O75477

  • Chr Location
    10q24.31; chr10:100150090-100186057 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4716
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ERLIN1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human ERLIN1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025198 Ensembl Gene Model | MGI Sequence Detail 34842 C57BL/6J ±  kb
transcript ENSMUST00000112028 Ensembl | MGI Sequence Detail 3136 Not Applicable  
polypeptide ENSMUSP00000107659 Ensembl | MGI Sequence Detail 348 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 7
Other
Accession IDs
less
MGI:1915460, MGI:2147792
References
more
  • Summaries
    All 34
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:208296 Huber MD, et al., Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis. J Cell Biol. 2013 Nov 11;203(3):427-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory