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Nags
Gene Detail
 Symbol
Name
ID
Nags
N-acetylglutamate synthase
MGI:2387600
Synonyms 1700120E20Rik
Feature Type protein coding gene
Genetic Map
Chromosome 11
65.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:102145513-102149477 bp, + strand
From VEGA annotation of GRCm38

  3965 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:77363  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: amino-acid acetyltransferase, animal type
Gene Tree: Nags

Human
homologs
Human Homolog NAGS, N-acetylglutamate synthase
NCBI Gene ID 162417
neXtProt AC  NX_Q8N159
Human Synonyms  AGAS, ARGA
Human Chr (Location)  17q21.31; chr17:44004664-44009068 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human NAGS
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
In the absence of N-carbamyl-L-glutamate and L-citrulline supplementation homozygous null mice develop severe hyperammonemia and die.
 
Human Diseases Modeled Using Mouse Nags (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process glutamate metabolic process, urea cycle
Component mitochondrion
Function acetyl-CoA:L-glutamate N-acetyltransferase activity, N-acetyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000002350 (Evidence)
Ensembl Gene ModelENSMUSG00000048217 (Evidence)
Entrez Gene217214 (Evidence)
UniGene31686
DFCITC1587111, TC1772970
DoTSDT.101362238, DT.55278616, DT.91329326
NIA Mouse Gene IndexU013383
EC2.3.1.1
Consensus CDS ProjectCCDS25488.1
International Mouse Knockout Project StatusNags
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002350 VEGA Gene Model | MGI Sequence Detail 3965 C57BL/6J ±  kb
transcript OTTMUST00000004679 VEGA | MGI Sequence Detail 2028 Not Applicable 
polypeptide OTTMUSP00000002248 VEGA | MGI Sequence Detail 527 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(3) UniProt(1)
Polymorphisms SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016181 Acyl-CoA N-acyltransferase
InterPro IPR001048 Aspartate/glutamate/uridylate kinase
InterPro IPR006855 Domain of unknown function DUF619
InterPro IPR000182 GNAT domain
InterPro IPR011243 N-acetylglutamate synthase, animal
Protein Ontology PR:000010964 N-acetylglutamate synthase, mitochondrial
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:184448 Senkevitch E, et al., A novel biochemically salvageable animal model of hyperammonemia devoid of N-acetylglutamate synthase. Mol Genet Metab. 2012 Jun;106(2):160-8
All references(35)
Other
accession IDs
MGI:1920851, MGI:2144153

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory