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Nags Gene Detail
Summary
  • Symbol
    Nags
  • Name
    N-acetylglutamate synthase
  • Synonyms
    1700120E20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387600
    NCBI Gene: 217214
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:102145513-102149477 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 65.48 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    34 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387600
protein coding gene Chr11:102145513-102149528 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019222
protein coding gene Chr11:105096118-105100066 (+)
A/J MGP_AJ_G0019190
protein coding gene Chr11:100657832-100661800 (+)
AKR/J MGP_AKRJ_G0019159
protein coding gene Chr11:103776601-103780549 (+)
BALB/cJ MGP_BALBcJ_G0019164
protein coding gene Chr11:101143083-101147036 (+)
C3H/HeJ MGP_C3HHeJ_G0018973
protein coding gene Chr11:103979681-103983629 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019613
protein coding gene Chr11:108368361-108372321 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017239
protein coding gene Chr11:98082794-98086740 (+)
CAST/EiJ MGP_CASTEiJ_G0018527
protein coding gene Chr11:104950284-104954244 (+)
CBA/J MGP_CBAJ_G0018942
protein coding gene Chr11:112841043-112845050 (+)
DBA/2J MGP_DBA2J_G0019054
protein coding gene Chr11:100182612-100186560 (+)
FVB/NJ MGP_FVBNJ_G0019044
protein coding gene Chr11:99711690-99715654 (+)
LP/J MGP_LPJ_G0019123
protein coding gene Chr11:105615226-105620594 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019075
protein coding gene Chr11:112365857-112369804 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019651
protein coding gene Chr11:104137642-104141589 (+)
PWK/PhJ MGP_PWKPhJ_G0018290
protein coding gene Chr11:101242959-101246918 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018082
protein coding gene Chr11:103891955-103898982 (+)
WSB/EiJ MGP_WSBEiJ_G0018576
protein coding gene Chr11:104129859-104133822 (+)



Homology
more
  • Human Ortholog
    NAGS, N-acetylglutamate synthase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NAGS, N-acetylglutamate synthase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AGAS, ARGA
  • Links
    NCBI Gene ID: 162417
    neXtProt AC: NX_Q8N159
    UniProt: Q8N159

  • Chr Location
    17q21.31; chr17:44004546-44009068 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
In the absence of N-carbamyl-L-glutamate and L-citrulline supplementation homozygous null mice develop severe hyperammonemia and die.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048217 Ensembl Gene Model | MGI Sequence Detail 3965 C57BL/6J ±  kb
    transcript ENSMUST00000055409 Ensembl | MGI Sequence Detail 2028 Not Applicable  
    polypeptide ENSMUSP00000050258 Ensembl | MGI Sequence Detail 527 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1920851, MGI:2144153
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:238739 Dercksen M, et al., A novel UPLC-MS/MS based method to determine the activity of N-acetylglutamate synthase in liver tissue. Mol Genet Metab. 2016 Dec;119(4):307-310

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    12/03/2019
    MGI 6.14
    The Jackson Laboratory