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Gabrp Gene Detail
Summary
  • Symbol
    Gabrp
  • Name
    gamma-aminobutyric acid (GABA) A receptor, pi
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387597
    NCBI Gene: 216643
  • Gene Overview
    MyGene.info: GABRP
Location & Maps
more
  • Sequence Map
    Chr11:33550781-33578959 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28179 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 19.21 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GABRP, gamma-aminobutyric acid type A receptor pi subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GABRP, gamma-aminobutyric acid type A receptor pi subunit
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 2568
    neXtProt AC: NX_O00591

  • Chr Location
    5q35.1; chr5:170772566-170814047 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 22798
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: GABRP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    3
  • Genomic Mutations
    1 involving Gabrp
  • Incidental Mutations
Homozygous mutation of this gene does not appear to result in a phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006342 VEGA Gene Model | MGI Sequence Detail 28179 C57BL/6J ±  kb
transcript OTTMUST00000014419 VEGA | MGI Sequence Detail 3280 Not Applicable  
polypeptide OTTMUSP00000006688 VEGA | MGI Sequence Detail 440 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    85 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007780 gamma-aminobutyric acid receptor subunit pi
  • InterPro Domains
    IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
    IPR008100 Gamma-aminobutyric-acid A receptor pi subunit
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Molecular
Reagents
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  • All nucleic 28
    cDNA 27
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 29
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:221789 Mo J, et al., Early growth response 1 (Egr-1) directly regulates GABAA receptor alpha2, alpha4, and theta subunits in the hippocampus. J Neurochem. 2015 May;133(4):489-500

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory