Ppp1r9b
Gene Detail

Symbol Name ID

Ppp1r9b protein phosphatase 1, regulatory subunit 9B MGI:2387581

Synonyms

MGC:38940, neurabin II, spinophilin, SPL, Spn

Feature Type

protein coding gene

Genetic Map

Chromosome 11

59.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:94991035-95006899 bp, + strand From VEGA annotation of GRCm38   15865 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32787  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 zebrafish

Gene Tree: Ppp1r9b

Human homologs

Human Homolog		PPP1R9B, protein phosphatase 1, regulatory subunit 9B
NCBI Gene ID		84687
neXtProt AC		NX_Q96SB3
Human Synonyms		PPP1R6, PPP1R9, SPINO, Spn
Human Chr (Location)		17q21.33; chr17:48211101-48227877 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygotes for a targeted null mutation exhibit abnormal glutamatergic synaptic transmission, reduced long-term depression, resistance to kainate-induced seizures, impaired taste aversion learning, and increased dendritic spine density.

 

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	actin cytoskeleton organization, actin filament organization, ...
Component	cell junction, cell projection, ...
Function	actin binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (32)    Tissues (31)    Images (9)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	30
Western blot	2

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(6) Genomic(1) cDNA(5)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000001501 (Evidence)
Ensembl Gene Model	ENSMUSG00000038976 (Evidence)
Entrez Gene	217124 (Evidence)
DFCI	TC1575930, TC1593490, TC1657211
DoTS	DT.110535259, DT.492214, DT.94132931
NIA Mouse Gene Index	U066142
Consensus CDS Project	CCDS25268.1
International Mouse Knockout Project Status	Ppp1r9b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001501	VEGA Gene Model | MGI Sequence Detail	15865	C57BL/6J
transcript	OTTMUST00000002970	VEGA | MGI Sequence Detail	4508	Not Applicable
polypeptide	OTTMUSP00000001457	VEGA | MGI Sequence Detail	817	Not Applicable

All sequences(35) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(101 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001478	PDZ domain
Protein Ontology	PR:000013133	neurabin-2

References

(Earliest) J:77284 Feng J, et al., Spinophilin regulates the formation and function of dendritic spines. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9287-92
(Latest) J:181706 Ma P, et al., A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling. Blood. 2012 Feb 23;119(8):1935-45
All references(41)