Catsper2
Gene Detail

Symbol Name ID

Catsper2 cation channel, sperm associated 2 MGI:2387404

Feature Type

protein coding gene

Genetic Map

Chromosome 2

60.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:121392631-121413792 bp, - strand From VEGA annotation of GRCm38   21162 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:77423  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 2 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Catsper2

Human homologs

Human Homolog		CATSPER2, cation channel, sperm associated 2
NCBI Gene ID		117155
neXtProt AC		NX_Q96P56
Human Chr (Location)		15q15.3; chr15:43922772-43941039 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human CATSPER2

Alleles and phenotypes

All alleles(26) : Targeted(5) Gene trapped(21)
 

Homozygous null male mice are infertile due to a sperm motility defect.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	calcium ion transmembrane transport, calcium ion transport, ...
Component	CatSper complex, cell projection, ...
Function	calcium channel activity, ion channel activity, ...

External Resources: FuncBase

Expression

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(11)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000015263 (Evidence)
Ensembl Gene Model	ENSMUSG00000033486 (Evidence)
Entrez Gene	212670 (Evidence)
UniGene	384318
DFCI	TC1589834, TC1616864
DoTS	DT.55123178, DT.94281034, DT.97396942
NIA Mouse Gene Index	U040969
Consensus CDS Project	CCDS38216.1
International Mouse Knockout Project Status	Catsper2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015263	VEGA Gene Model | MGI Sequence Detail	21162	C57BL/6J
transcript	OTTMUST00000036170	VEGA | MGI Sequence Detail	2247	Not Applicable
polypeptide	OTTMUSP00000016321	VEGA | MGI Sequence Detail	588	Not Applicable

All sequences(33) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(49 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005821	Ion transport domain
InterPro	IPR001646	Pentapeptide repeat
InterPro	IPR027359	Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology	PR:000000670	cation channel sperm-associated protein 2

References

(Earliest) J:78669 Quill TA, et al., A voltage-gated ion channel expressed specifically in spermatozoa. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12527-31
(Latest) J:182472 Chung JJ, et al., A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun. 2011 Jan 11;2:153
All references(38)