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Catsper2 Gene Detail
Summary
  • Symbol
    Catsper2
  • Name
    cation channel, sperm associated 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387404
    NCBI Gene: 212670
  • Gene Overview
    MyGene.info: CATSPER2
Location & Maps
more
  • Sequence Map
    Chr2:121392631-121413792 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21162 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 60.38 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CATSPER2, cation channel sperm associated 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CATSPER2, cation channel sperm associated 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 117155
    neXtProt AC: NX_Q96P56

  • Chr Location
    15q15.3; chr15:43630562-43648845 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human CATSPER2 associations

Human Disease Mouse Models
       Deafness-Infertility Syndrome; DIS   OMIM: 611102
Spermatogenic Failure 7; SPGF7   OMIM: 612997
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    28
  • Chemically induced (other)
    1
  • Gene trapped
    21
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Catsper2
  • Incidental Mutations
    APF
Homozygous null male mice are infertile due to a sperm motility defect.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015263 VEGA Gene Model | MGI Sequence Detail 21162 C57BL/6J ±  kb
transcript OTTMUST00000036170 VEGA | MGI Sequence Detail 2247 Not Applicable  
polypeptide OTTMUSP00000016321 VEGA | MGI Sequence Detail 588 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    91 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000000670 cation channel sperm-associated protein 2
  • InterPro Domains
    IPR011989 Armadillo-like helical
    IPR028747 Cation channel sperm-associated protein 2
    IPR005821 Ion transport domain
    IPR001646 Pentapeptide repeat
    IPR027359 Voltage-dependent channel, four helix bundle domain
Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 4
References
more
  • Summaries
    All 34
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:78669 Quill TA, et al., A voltage-gated ion channel expressed specifically in spermatozoa. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12527-31
  • Latest
    J:182472 Chung JJ, et al., A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun. 2011 Jan 11;2:153

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory