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Catsper2
Gene Detail
Symbol

Name
ID
Catsper2
cation channel, sperm associated 2
MGI:2387404
Feature Type
protein coding gene
Genetic Map
Chromosome 2
60.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:121392631-121414581 bp, - strand
From VEGA annotation of GRCm38

  21951 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:77423  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 2 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CATSPER2
Gene Tree: Catsper2

Human
homologs
CATSPER2, cation channel, sperm associated 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 117155
neXtProt AC: NX_Q96P56

Human Chr (Location): 15q15.3; chr15:43630562-43648845 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CATSPER2

Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(21) Targeted(5)
Incidental mutations (data from APF )
 
Homozygous null male mice are infertile due to a sperm motility defect.
 
Interactions
Catsper2 interacts with 153 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process calcium ion import, calcium ion transmembrane transport, ...
Component CatSper complex, cell projection, ...
Function calcium activated cation channel activity, calcium channel activity, ...
External Resources: FuncBase
Expression
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000015263 (Evidence)
Ensembl Gene Model ENSMUSG00000033486 (Evidence)
Entrez Gene 212670 (Evidence)
UniGene 384318
DFCI TC1589834, TC1616864
DoTS DT.55123178, DT.94281034, DT.97396942
NIA Mouse Gene Index U040969
Consensus CDS Project CCDS38216.1
International Mouse Phenotyping Consortium Status Catsper2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015263 VEGA Gene Model | MGI Sequence Detail 21951 C57BL/6J ±  kb
transcript OTTMUST00000036170 VEGA | MGI Sequence Detail 2247 Not Applicable 
polypeptide OTTMUSP00000016321 VEGA | MGI Sequence Detail 588 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(18) UniProt(4)
Polymorphisms
SNPs within 2kb(81 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR005821 Ion transport domain
InterPro IPR001646 Pentapeptide repeat
InterPro IPR027359 Voltage-dependent potassium channel, four helix bundle domain
Protein Ontology PR:000000670 cation channel sperm-associated protein 2
References
(Earliest) J:78669 Quill TA, et al., A voltage-gated ion channel expressed specifically in spermatozoa. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12527-31
(Latest) J:182472 Chung JJ, et al., A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun. 2011 Jan 11;2:153
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory