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Gab3 Gene Detail
Summary
  • Symbol
    Gab3
  • Name
    growth factor receptor bound protein 2-associated protein 3
  • Synonyms
    5930433H21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387324
    NCBI Gene: 210710
  • Alliance
Location &
Maps
more
  • Sequence Map
    ChrX:74988545-75084905 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 38.12 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    98 from dbSNP Build 142
  • Strain Annotations
    10
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2387324
protein coding gene ChrX:74966843-75085458 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0035839
protein coding gene ChrX:71019806-71122388 (-)
AKR/J MGP_AKRJ_G0035760
protein coding gene ChrX:72894384-73005814 (-)
BALB/cJ MGP_BALBcJ_G0035821
protein coding gene ChrX:70046313-70146728 (-)
C3H/HeJ MGP_C3HHeJ_G0035531
protein coding gene ChrX:71295211-71392455 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036351
protein coding gene ChrX:73070829-73202412 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0035504
protein coding gene ChrX:75034570-75156467 (-)
DBA/2J MGP_DBA2J_G0035662
protein coding gene ChrX:70496427-70603437 (-)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0034514
protein coding gene ChrX:54631483-54755229 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0034956
protein coding gene ChrX:69911811-70010372 (-)



Homology
more
  • Human Ortholog
    GAB3, GRB2 associated binding protein 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GAB3, GRB2 associated binding protein 3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 139716
    neXtProt AC: NX_Q8WWW8
    UniProt: Q8WWW8

  • Chr Location
    Xq28; chrX:154675249-154751583 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 15417
    1 human;1 mouse;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GAB3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotype references
Females homozygous and males hemizygous for disruptions in this X-linked gene developed normally, exhibted normal hematopoiesis, and were immunocompetent.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 210710 NCBI Gene Model | MGI Sequence Detail 96361 C57BL/6J ±  kb
transcript NM_181584 RefSeq | MGI Sequence Detail 2129 C57BL/6  
polypeptide Q8BSM5 UniProt | EBI | MGI Sequence Detail 595 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 1
Other
Accession IDs
less
MGI:2445045
References
more
  • Summaries
    All 19
    Gene Ontology 1
    Phenotypes 3
  • Earliest
    J:78670 Wolf I, et al., Gab3, a new DOS/Gab family member, facilitates macrophage differentiation. Mol Cell Biol. 2002 Jan;22(1):231-44
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory